Dr. Strome received his BA from Dartmouth College in 1987 and his medical degree from Harvard Medical School in 1991. He subsequently completed a combined 6-year internship/residency program at the University of Michigan Medical Center in 1997 and a head and neck surgery/microvascular reconstructive fellowship with Dr. Richard Hayden in 1998. He accepted a faculty position in the Department of Oto-HNS at the Mayo Clinic College of Medicine in 1998, where he practiced until being recruited to head the Department of Oto-HNS at the University of Maryland School of Medicine.
Dr. Strome runs a large translational research program, has a long history of federal funding and has published extensively in leading scientific journals. From a clinical perspective, he is interested in all aspects of head and neck cancer patient care with a particular emphasis on salivary gland disease, laryngeal disease, thyroid disease and head and neck reconstruction.
Dr. Strome's research program is focused on the study of mechanisms to harness the immune response to squamous cell carcinoma of the head and neck (SCCHN) for purposes of diagnoses/monitoring and therapy. From a diagnostic perspective, Dr. Strome’s laboratory is studying the humoral response to specific tumor antigens both as a prognostic indicator and as tool to identify antigen specific T cell function.
The therapeutic component of Dr. Strome’s research is geared toward the development of antigen specific vaccines to stimulate priming of the immune response with subsequent manipulation of specific costimulatory pathways to enhance antitumor effector T cell function. These studies include characterizing the protein structure and function of costimulatory molecules at the molecular level and assessing their suitability for clinical use.
Additionally, Dr. Strome’s laboratory is developing means to determine the utility of bone marrow derived effector cells for antitumor therapy. Dr. Strome’s laboratory is funded by a combination of extramural, industry, institutional and philanthropic support.