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Mohamed  Hashem
 

Mohamed Hashem M.B.,B.Ch.

Academic Title: Assistant Professor
Primary Appointment: Epidemiology & Public Health
mhashem@epi.umaryland.edu
Location: HH, 102B
Phone: (410) 706-3098 (Epidemiology office)
Phone: +2-010-259-1201 (Cairo; current location)
Fax: (410) 706-8013

Personal History:

Education

1978-84: Faculty of Medicine, M.B.B.Ch. (M.D. equivalent), Cairo University, Cairo, Egypt

1990: Faculty of Medicine, M.Sc. Pediatrics, Cairo University Children’s Hospital, Cairo, Egypt

2001-2004: Post-DoctoralClinical Fellow, Department of Pediatrics, Division of Pediatric Infectious Diseases, Golisano Children’s Hospital at Strong, University of Rochester, Rochester, New York

Post Graduate Education and Training

1985-86: House officer, Cairo University Hospitals, Cairo, Egypt

1986-87: Rural services and Public Health services General Practitioner, Ministry of Health and Population, Egypt.

1987-90: Internship/Residency in Pediatrics, Department of Pediatrics, Cairo University Children’s Hospital, Cairo, Egypt

1990-93: Study Coordinator, Collaborative study with the Department of International Health-Johns Hopkins University and WHO/CDD Gastroenteritis Unit, Cairo University Children's Hospital

1993-94: Staff Physician, Emergency Department, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia

1994-97: Post-Doctoral Fellow, Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland.

1997-98: Research Associate, Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland.

1998-99: Internship, Department of Pediatrics,Sisters of Charity Medical Center, St. Vincent’s Campus, Staten Island, New York

1999-2001: PL-2/PL-3, Department of Pediatrics, Sisters of Charity Medical Center, St. Vincent’s Campus, Staten Island, New York

2001-04: Pediatrics ID Fellow, Department of Pediatrics, Division of Pediatric Infectious Diseases, Golisano Children’s Hospital at Strong, University of Rochester Medical Center, Rochester, New York

2005-present: Assistant Professor, Division of International Health, Department of Epidemiology & Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland

Research Interests:

I am an Assistant Professor at the International Health Division, Department of Epidemiology and Preventive Medicine at the University of Maryland School of Medicine. My current work location is Egypt, where I am involved in multiple studies re: Hepatitis C Virus (HCV), in addition to my administrative responsibilities as the Project Manager for the University of Maryland-(HCV) program in Egypt. As the Research project management I am leading the research team in Cairo involved in the Day-to-day aspects of running the project and assuring compliance with the protocol, quality assurance of data collection, clinical monitoring Capacity Building Teaching/ Lecturing Grant and manuscript writing

Following is a description of my clinical and bench research experience so far in my career.

In the period 1990-1993, I was a clinical investigator on an International Group conducting clinical trials focused on improving the management of acute diarrheal illnesses in children 1-6. These RCT were conducted under the auspices of the World Health Organization in collaboration with the Department of International Health, Johns Hopkins University and conducted in the Department of Pediatrics, Cairo University Children’s Hospital. In these studies, I led the research team in Cairo and coordinated the day to day activities with the local PI and with Hopkins investigators, setting up all the necessary logistics to conduct the studies at Cairo, training all the junior physicians and nurses in conducting the clinical trials, and supervising the junior staff and nurses to ensure the quality of data collection.

In 1994 I moved to the U.S. where for the following four years I worked as a Post-doctoral Fellow, then as a Research Associate in the Department of International Health (DIH) at JHU. The research that I have been involved in (1994-1996) has been a continuation of the previous research alluded to above. I coordinated and monitored a multi center clinical trial conducted at three sites, one in Mexico City 7, and the other two sites in Cairo. I visited the study sites at regular intervals during the study with the purpose of standardizing methodology among the three sites, verifying adherence to the protocol and the completeness and accuracy of the documentation. As a Post Doctoral Fellow, I attended classes in the School of Hygiene at JHU, to obtain skills in field of Epidemiology, and Biostatistics that are relevant to clinical trials.

In July 1997, I was appointed a Research Associate in the DIH, JHU. I was one of the field physicians in charge of conducting and coordinating the new pneumococcal conjugate vaccine efficacy trial conducted on the Navajo and Apache Indian Reservation.

Starting July 1998, I began my pediatric residency training, at Saint Vincent Catholic Medical Center, Staten Island New York. During my residency I participated in studies investigating the prevalence and molecular typing of penicillin-nonsusceptible Streptococcal pneumoniae (PNSP) in a Staten Island Pediatric Population and in the in metropolitan New York hospitals 8.

I then completed my three years of training as a pediatric infectious disease fellow at University of Rochester Medical Center, in September 2004. As a Fellow I conducted basic research of infections in the immunocompromised host. My primary project studied the role of the placenta in the vertical transmission of HIV 9.

After finishing my fellowship, I accepted an academic position at the University of Maryland in the Department of Epidemiology and Preventive Medicine (DEPM), Division of International Health (DIH). Over the past eight years investigators from DIH had the opportunity to study hepatitis C and E infection in Egypt in a very systematic and organized manner in collaboration with the Ministry of Health and Population. These studies led to important discoveries, and provided vital information that may ultimately lead to prevention and treatment of these infections. I am a co investigator on some of these studies. I am also co investigator on a recently funded NIAID grant. Through this grant we developed two specialty clinics in Cairo/Egypt to provide care for, and prospectively follow, an HCV-infected pediatric cohort to study the natural history of HCV in Egyptian children and other studies to studies to study the cellular mediated immune response (CMI) in hepatitis C infected individuals.

I am also a co investigator on a recently funded WHO (EMRO/TDR) grant to evaluate rubella serosusceptibility among Egyptian females in late Childhood and early childbearing period. This will assist the Egyptian MOH&P developing an optimal vaccination strategy by targeting females who are susceptible to rubella and ensuring high levels of rubella immunity among women in the childbearing age to prevent congenital rubella infection and CRS.


Publications:

Refereed Publications

Santosham M, Fayad IM, Hashem M, Goepp JG, Refat M, and Sack RB. A comparison of rice-based oral rehydration solution and "early feeding" for the treatment of acute diarrhea in infants. J Ped 1990; 116(6):868-875

Fayad IM, Hashem M, Duggan C, Refat M, Bakir M, Fontaine O, and Santosham M. Comparative efficacy of rice-based and glucose-based oral rehydration salts plus early reintroduction of food. Lancet 1993; 12(10):812-15

Duggan C, Wolff M, Refat M, Hashem M, Fayad IM, and Santosham M. Clinical signs of dehydration: A comparison of two dehydration scoring systems. Pediatric Research 1993; 33:116A

Duggan C, Refat M, Hashem M, Wolff M, Fayad IM, and Santosham M. How valid are Clinical signs of dehydration in infants? J Pediatric Gastroenterology and Nutrition. 1996; 22(1)56-61

Santosham M, Fayad IM, Abu Zikri M, Hussein A, Duggan C, Hashem M, E l Sady N, Abu Zikri Mona and Fontaine O. A double blind clinical trial comparing WHO ORS solution with reduced osmolarity ORS solution containing equal amounts of sodium and glucose. J Pediar 1996; 28:45-51

Duggan C, Refat M, Hashem M, Wolff M, Fayad IM, and Santosham M. Interrater Agreement in the assesment of dehydration in infants (letter) J Tropical Pediatrics 1997; 43(2):119-21

Fayad IM, Hashem M, Hussein A, Abou Zikri M, Abu Zikri M, Santosham M, Comparison of soy-based formulas with lactose and with sucrose in the treatment of acute diarrhea in infants. Arch Pediatr Adolesc Med 1999;153:675-680

Maulen-Radovan I, Gutierrez-Castrellon P, Hashem M, Neylan M, Baggs G, Zaldo R, Ndife LI, Pollack PF, Santosham M. Safety and efficacy of a premixed, rice-based oral rehydration solution. J Pediatr Gastroenterol Nutr. 2004 Feb;38(2):159-63.

Shata MT, Barrett A, Shire NJ, Abdelwahab SF, Sobhy M, Daef E, El-Kamary SS, Hashem M, Engle RE, Purcell RH, Emerson SU, Strickland GT, Sherman KE. Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay. J Immunol Methods. 2007 Dec 1;328(1-2):152-61.

Kamal SM, El Kamary SS, Shardell MD, Hashem M, Ahmed IN, Muhammadi M, Sayed K, Moustafa A, Hakem SA, Ibrahiem A, Moniem M, Mansour H, Abdelaziz M.Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: The role of rapid and early virologic response. Hepatology. 2007 Dec;46(6):1732-40.

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt Mbulaiteye SM, Pfeiffer RM, Dolan B, Tsang VC, Noh J, Mikhail NN, Abdel-Hamid M, Hashem M, Whitby D, Thomas Strickland G, Goedert JJ. Emerging Infection Disease 2008;14(4): 2008 Apr;14 (4):586-91 2008 Apr;14(4):586-91

Saleh DA, Shebl F, Abdel-Hamid M, Narooz S, Mikhail N, El-Batanony M, El-Kafrawy S, El-Daly M, Sharaf S, Hashem M, El-Kamary S, Magder LS, Stoszek SK, Strickland GT. Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt. Trans R Soc Trop Med Hyg. 2008 May 29. [Epub ahead of print]

Invited Articles

Hashem M and Hall CB. Respiratory Syncytial Virus in healthy adults: the cost of a cold. Journal Clinical Virology 2003;27(1):14-21.

Hashem M and Menegus MA. Molecular Tools in the Diagnosis and Management of Infectious Diseases. Pediatrics in Review. 2005;26:15-20

Book Chapter

Edwin Asturias, Kenneth Petersen, Mohamed Hashem, Mathuram Santosham. "Infectious Diseases" IN: American Native Health Innovations in Health Care, Promotion, and Policy. Editor: Everett Rhoades, The Johns Hopkins University Press.