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William C. Blackwelder

William C. Blackwelder Ph.D.

Academic Title: Professor
Primary Appointment: Medicine
Additional Title(s): Senior Biostatistician
Location: HSF 1, Room 480
Phone: (410) 706-7924
Fax: (410) 706-6205

Personal History:

Dr. Blackwelder comes to the CVD after a distinguished career at the National Institutes of Health (NIH) and five years as a biostatistical consultant. At the National Institute of Allergy and Infectious Diseases (NIAID), he led a Biometry unit in the Division of Microbiology and Infectious Diseases (DMID) and had overall responsibility for statistical consulting with scientists within DMID, clinical investigators within NIAID and investigators outside NIH. He consulted and collaborated on numerous clinical trials and observational studies, especially randomized vaccine trials. In particular, he played a critical role in the development of acellular pertussis vaccines. Currently, he provides statistical leadership for CVD projects and lectures on statistics for the Department of Epidemiology and Preventive Medicine’s course in vaccinology. He consults with clinical and laboratory investigators on design and analysis of CVD research studies. His biostatistical research interest is in methods for design and analysis in clinical trials.


Simonsen L, Reichert TA, Blackwelder W, Miller MA. Benefits of influenza vaccination on influenza-related mortality among elderly in the US: an unexpected finding. In Options for the Control of Influenza V, Kawaoka ed. Elsevier, International Congress Series: 1263; 163-167, 2004.

Gladwin MT, Sachdev V, Jison ML, Shizukuda Y, Plehn JF, Minter K, Brown B, Coles WA, Nichols JS, Ernst I, Hunter LA, Blackwelder WC, Schechter AN, Rodgers GP, Castro O, Ognibene FP. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. New England Journal of Medicine 350: 886-895, 2004.

Blackwelder WC. Current Issues in Clinical Equivalence Trials. Journal of Dental Research 83 (Spec Iss C): C113-C115, 2004.

Hopkins RJ, Kramer WG, Blackwelder WC, Ashtekar M, Hague L, Winker-La Roche SD, Berezuk G, Smith D, Leese PT. Safety and pharmacokinetic evaluation of intravenous vaccinia immune globulin in healthy volunteers. Clinical Infectious Diseases 39: 759-766, 2004.
Simonsen L, Reichert TA, Viboud C, Blackwelder WC, Taylor RJ, Miller MA. Impact of influenza vaccination on seasonal mortality in the US elderly. Accepted for publication,  Archives of Internal Medicine 165: 265-272, 2005.

Kato GJ, Martyr S, Blackwelder WC, Nichols JS, Coles WA, Hunter LA, Brennan M-L, Hazen SL, Gladwin MT. Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. British Journal of Haematology 130: 943-953, 2005.

Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. Journal of the American Medical Association 294: 81-90, 2005.