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Ashish C. Nagarsekar

Ashish C. Nagarsekar Ph.D.

Academic Title: Instructor
Primary Appointment: Medicine
Location: VAMHCS, 3C116
Phone: (410) 605-7000, ext 6532

Research Interests:

Effect of hyperthermia on lung epithelial cells


Hyperthermia Promotes and Prevents Respiratory Epithelial Apoptosis through Distinct Mechanisms. Nagarsekar A, Tulapurkar ME, Singh IS, Atamas SP, Shah NG, Hasday JD. Am J Respir Cell Mol Biol. 2012 Sep 6.

Fever, hyperthermia, and the lung: it's all about context and timing. Hasday JD, Shah N, Mackowiak PA, Tulapurkar M, Nagarsekar A, Singh I. Trans Am Clin Climatol Assoc. 2011;122:34-47. Review.

Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils. Nagarsekar A, Greenberg RS, Shah NG, Singh IS, Hasday JD. J Immunol. 2008 Aug 15;181(4):2636-43.

Heat shock co-activates interleukin-8 transcription. Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, Hester L, Benjamin IJ, He JR, Hasday JD. Am J Respir Cell Mol Biol. 2008 Aug;39(2):235-42.

CXC chemokines: a new family of heat-shock proteins? Nagarsekar A, Hasday JD, Singh IS. Immunol Invest. 2005;34(3):381-98. Review.

Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia. Rice P, Martin E, He JR, Frank M, DeTolla L, Hester L, O'Neill T, Manka C, Benjamin I, Nagarsekar A, Singh I, Hasday JD. J Immunol. 2005 Mar 15;174(6):3676-85.

Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site. Huang N, Nagarsekar A, Xia G, Hayashi J, MacKerell AD Jr. J Med Chem. 2004 Jul 1;47(14):3502-11.

Genetic engineering of stimuli-sensitive silkelastin-like protein block copolymers. Nagarsekar A, Crissman J, Crissman M, Ferrari F, Cappello J, Ghandehari H. Biomacromolecules. 2003 May-Jun;4(3):602-7.

Genetic synthesis and characterization of pH- and temperature-sensitive silk-elastinlike protein block copolymers. Nagarsekar A, Crissman J, Crissman M, Ferrari F, Cappello J, Ghandehari H. J Biomed Mater Res. 2002 Nov;62(2):195-203.

Genetically engineered polymers for drug delivery. Nagarsekar A, Ghandehari H. J Drug Target. 1999;7(1):11-32. Review.