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Research Interests
Effect of hyperthermia on lung epithelial cells
Publications
Hyperthermia Promotes and Prevents Respiratory Epithelial Apoptosis through Distinct Mechanisms. Nagarsekar A, Tulapurkar ME, Singh IS, Atamas SP, Shah NG, Hasday JD. Am J Respir Cell Mol Biol. 2012 Sep 6.
Fever, hyperthermia, and the lung: it's all about context and timing. Hasday JD, Shah N, Mackowiak PA, Tulapurkar M, Nagarsekar A, Singh I. Trans Am Clin Climatol Assoc. 2011;122:34-47. Review.
Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils. Nagarsekar A, Greenberg RS, Shah NG, Singh IS, Hasday JD. J Immunol. 2008 Aug 15;181(4):2636-43.
Heat shock co-activates interleukin-8 transcription. Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, Hester L, Benjamin IJ, He JR, Hasday JD. Am J Respir Cell Mol Biol. 2008 Aug;39(2):235-42.
CXC chemokines: a new family of heat-shock proteins? Nagarsekar A, Hasday JD, Singh IS. Immunol Invest. 2005;34(3):381-98. Review.
Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia. Rice P, Martin E, He JR, Frank M, DeTolla L, Hester L, O'Neill T, Manka C, Benjamin I, Nagarsekar A, Singh I, Hasday JD. J Immunol. 2005 Mar 15;174(6):3676-85.
Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site. Huang N, Nagarsekar A, Xia G, Hayashi J, MacKerell AD Jr. J Med Chem. 2004 Jul 1;47(14):3502-11.
Genetic engineering of stimuli-sensitive silkelastin-like protein block copolymers. Nagarsekar A, Crissman J, Crissman M, Ferrari F, Cappello J, Ghandehari H. Biomacromolecules. 2003 May-Jun;4(3):602-7.
Genetic synthesis and characterization of pH- and temperature-sensitive silk-elastinlike protein block copolymers. Nagarsekar A, Crissman J, Crissman M, Ferrari F, Cappello J, Ghandehari H. J Biomed Mater Res. 2002 Nov;62(2):195-203.
Genetically engineered polymers for drug delivery. Nagarsekar A, Ghandehari H. J Drug Target. 1999;7(1):11-32. Review.