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Richard Y. Zhao

Richard Y. Zhao Ph.D.

Academic Title: Professor
Primary Appointment: Pathology
Secondary Appointments: Microbiology and Immunology
Additional Title(s): Head, Division of Molecular Pathology, Department of Pathology & Director, Molecular Diagnostics Laboratory, UMMC
Location: MSTF 6-00E
Phone: (410) 706-6301 (Office)
Phone: (410) 706-6310 (Research Lab)
Fax: (410) 706-6303
Lab: (410) 328-2969 (Clinical Lab)

Research Interests:

Molecular, Cellular and Virologic Characterizations of HIV-1 Viral Protein R (Vpr) Interactions with Host Cellular Responses Research Interests

My general research interest is in the area of host-pathogen interactions specifically to study the effects of viral infections on host cellular activities. Our current research focus is to investigate the roles of HIV-1 viral protein R (Vpr) in cell cycle G2/M controls, apoptosis and elicitation of other host cellular responses. Our research strategy is to integrate the use of fission yeast (Schizosaccharomyces pombe) as a model system with further translations of yeast findings into mammalian and viral infection systems. This combined research strategy represents main research strength of our research programs, which allows us to uncover many of the molecular or cellular insights of HIV-1 Vpr that are sometimes difficult or impossible to reveal solely by studying mammalian cells.


 Li, G., R.T. Elder, K. Qin, H.U. Park, D. Liang and R.Y. Zhao. 2007. PP2A-dependent and independent ATR phosphorylation of Chk1. Journal of Biological Chemistry. 282 (10)7287-7298.
Liang, D., Z, Benko, E. Agbottah, L. Taricani, P.G. Young, M. Bukrinsky, and R.Y. Zhao. 2007. HSP27 as a Potential Intrinsic Anti-HIV Factor Targeting HIV-1 Viral Protein R. Molecular Medicine 13(5-6):229-239.
Benko, Z., D. Liang, E. Agbottah, J.Hou, L. aricani, P.Reed, P.G. Young, M.Bukrinsky, and R.Y. Zhao. 2007. Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 activation in fission yeast (Schizosaccharomyces pombe). Retrovirology. 4(16):1742-.
Finan, J. and Zhao, R.Y. 2007. Molecular diagnostics to personalized medicine (invited review). Pharmacogenomics. 8(1):85-99.
Zelivianski, S, D. Liang, M. Chen, B. L. Mirkin, R.Y. Zhao. 2006. Suppressive Effect of Elongation Factor 2 on Apoptosis Induced by HIV-1 Viral Protein R. Apoptosis. 11(3):377-88.
Zhang, Y., Qin, K., Wang, J., Hung, T.*, and R. Y. Zhao*. 2006. Dividing Roles of Prion Protein in Staurosporine-mediated Apoptosis. Biochemical and Biophysical Research Communication, 349(2):759-768. (*, co-corresponding author)
Qin, K. L. Zhao, Y. Tang, S. Bhatta, J. M. Simard, R.Y. Zhao. 2006. Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes. Neuroscience. 141(3):1375-1388.
Qin, K., M. O’Donnell, and R.Y. Zhao. 2006. Doppel: More Rival than Double to Prion. Neuroscience. 141(1):1-8.
Fenyvesvolgyi, C. R.T. Elder, Z. Benko, D. Liang, and R.Y. Zhao. 2005. Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sources. Biochimica et Biophysica Acta. 1746(2):155-62.
Daniel, R. E. Marusich, E. Argyris, R.Y. Zhao, A.M. Skalka and R.J. Pomerantz. 2005. Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells. Journal of Virology. 79(4):2058-65.
Zhao, R.Y., and R.T. Elder. 2005. Viral Infections and cell cycle G2/M regulation (invited review). Cell Research. 15(3):143-9.
Zhao, R.Y. 2005. From single cell gene-based diagnostics to diagnostic genomics: current applications and future perspectives. Clinical Laboratory Sciences. 18(4):254-262.
Li, L., Li, H., C.D. Pauza, M. Bukrinsky and R.Y. Zhao. 2005. HIV-host interaction: role of accessory proteins. In: “HIV/AIDS in China” R.Y. Zhao (ed.). Cell Research. 15(11-12):923-934.
Benko, Z., D. Liang, E. Agbottah, J. Hou, K. Chiu, M. Yu, S. Innis, P. Reed, W. Kabat, R.T. Elder, P. Di Marzio, Ratner, P.G. Young, M. Bukrinsky and R. Y. Zhao. 2004. Anti-Vpr activity of a yeast chaperone protein. Journal of Virology. 78(20):11016-11029.
Iordanskiy, S., R.Y. Zhao, L. Dubrovsky, T. Iordanskaya, M. Chen, D. Liang, and M. Bukrinsky. 2004. Heat-shock protein 70 protects cells from HIV-1 infection by targeting viral protein R. Journal of Virology. 78(20):9697-9704.
Iordanskiy, S.*, R.Y. Zhao*, P. DiMarzio, I. Agostini, L. Dubrovsky, and M. Bukrinsky. 2004. Heat-shock protein 70 exerts opposite effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages. Blood 104(6):1867-1872. (* co-first author).
Bukrinsky, M. and R.Y. Zhao. 2004. Heat-shock proteins reverse the G2 arrest caused by HIV-1 viral protein R. DNA and Cell Biology. 23(4):223-5.