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Miriam K Laufer
 

Miriam K Laufer M.D.

Academic Title: Associate Professor
Primary Appointment: Pediatrics
Secondary Appointments: Epidemiology & Public Health, Medicine
mlaufer@medicine.umaryland.edu
Location: HSF1, Room 480
Phone: (410) 706-8695
Fax: (410) 706-2999

Personal History:

Dr. Miriam Laufer is Associate Professor of Pediatrics, Medicine, Epidemiology and Public Health, and Faculty of the graduate program in Microbiology and Immunology at the University of Maryland School of Medicine. She received her medical degree at the University of Pennsylvania and completed her residency in pediatrics at Babies and Children’s Hospital of New York (now New York Children’s Hospital) of Columbia University. She completed fellowships in pediatric infectious diseases at Johns Hopkins University and in malaria research at the Center for Vaccine Development at the University of Maryland. She received her MPH from the Bloomberg School of Public Health at Johns Hopkins University.

Dr. Laufer is a pediatric infectious disease specialist, with a primary research interest in malaria. She has conducted research, clinical care and professional education in several developing countries, but has dedicated the past decade to working in Malawi. She currently serves as Principal Investigator for two NIAID-funded clinical trials being conducted in Blantyre, Malawi as well as the project leader for the clinical epidemiology portion of Malawi’s International Center for Excellence in Malaria Research. Her research studies focus on malaria epidemiology in various transmission settings throughout Malawi, malaria during pregnancy and its impact on infants, and the interaction between HIV and malaria. Her laboratory at the University of Maryland explores the application of molecular epidemiology tools to address critical issues related to malaria pathogenesis, disease burden and drug resistance. She is the Program Director for the Pediatric Infectious Diseases Fellowship at the University of Maryland School of Medicine, and she leads the Malawi Summer Inter-professional Global Health program that brings faculty and students from all the professional schools at the University of Maryland, Baltimore, including the Schools of Nursing, Pharmacy, Social Work and Law to work together on a critical global health issue every year.

Research Interests:

Dr. Laufer is a pediatric infectious disease specialist, with a primary research interest in malaria. She currently conducts clinical trials in Malawi focusing on the epidemiology of drug-resistant malaria, with the goal of understanding how resistance emerges and of developing strategies to deter it. Dr. Laufer is also interested in the interaction between HIV and malaria, infections that coexist in much of sub-Saharan Africa. In the past, Dr. Laufer directed a pediatric training program in Laos, and she continues to volunteer her time to train Lao physicians.


Publications:

  1. Laufer MK, van Oosterhout JJ, Thesing PC, Graham SM, Thumba F, Zijlstra EE, Taylor  TE, Plowe CV. Impact of HIV-Associated Immunosuppression on Malaria Infection and Disease in Malawi. Journal of Infectious Diseases 193:872-8, 2006. PMID 16479522
  2. Rigau JR, Laufer MK. Dengue-related Deaths in Puerto Rico, 1992-1996: Diagnosis and Clinical Alarm Signals. Clinical Infectious Diseases 142(9):1241-6, 2006. PMID 16586382
  3. Laufer MK, van Oosterhout JJ, Perez MA, Kanyanganlika J, Taylor TE, Plowe CV, Graham SM. Observational cohort study of HIV-infected African children. Pediatric Infectious Diseases Journal 25(7):623-7, 2006. PMID 16804433
  4. Laufer MK, Thesing PC, Eddington ND, Masonga R, Dzinjalamala FK, Takala SL, Taylor TE, Plowe CV. Return of chloroquine antimalarial efficacy in Malawi. New England Journal of Medicine 255:1959-1966, 2006. PMID 17093247
  5. Laufer MK, Plowe CV. The interaction between HIV and malaria in Africa. Current Infectious Diseases Reports 9(1):47-54, 2007. PMID 17254504
  6. Laufer MK, van Oosterhout JJ, Thesing PC, Dzinjalamala FK, Hsi T, Beraho L, Graham SM, Taylor  TE, Plowe CV. Malaria treatment efficacy among people living with HIV: the role of parasite host and parasite factors. American Journal of Tropical Medicine and Hygiene 77(4): 627-633, 2007. PMID 17978061
  7. Laufer MK, Djimde AA, Plowe CV. Monitoring and deterring drug resistant malaria in the era of combination therapy. American Journal of Tropical Medicine and Hygiene. 77(6 Suppl):160-169, 2007. PMID 18165489
  8. Laufer MK, Takala-Harrison S, Dzinjalamala FK, Stine OC, Taylor TE, Plowe CV. Return of chloroquine-susceptible falciparum malaria in Malawi was a re-expansion of diverse susceptible parasites. Journal of Infectious Diseases. 202(5):801-9, 2010. PMC3380613
  9. Frosch AE, Venkatesan M, Laufer MK. Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data. Malar J. 10(1):116, 2011. PMC3112453
  10. Mathanga DP, Walker ED, Wilson ML, Ali D, Taylor TE, Laufer MK. Malaria control in Malawi: Current status and directions for the future. Acta Tropica. Mar;121(3):212-7, 2012. PMID 21763670
  11. Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG, Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malaria Journal. 11:207, 2012. PMC3489583
  12. Laufer MK, Thesing PC, Dzinjalamala FK, Nyirenda OM, Masonga R, Laurens MB, Stokes-Riner A, Taylor TE, Plowe CV. A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. PLoS One. 7(8):e42284, 2012. PMC3422316
  13. Wylie BJ, Kalilani-Phiri L, Madanitsa M, Membe G, Nyirenda O, Mawindo P, Kuyenda R, Malenga A, Masonbrink A, Makanani B, Thesing P, Laufer MK. Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi. Malar J. 2013 Jun 4;12:183. PubMed PMID: 23734718; PubMed Central PMCID: PMC3679840.