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Heather J Ezelle Ph.D.

Academic Title: Research Associate
Primary Appointment: Microbiology and Immunology
hezelle@som.umaryland.edu
Location: Howard Hall, 333
Phone: (410) 328-2345
Fax: (410) 706-6609

Publications:

Ezelle, H.J., Balachandran, S., Sicheri, F., Polyak, S.J., and Barber, G.N. (2001). Analyzing the mechanisms of interferon inducing apoptosis using CrmA and hepatitis C virus NS5A. Virology. 281 (1): 124-37.

Polyak, S.J., Khabar, K.S., Paschal, D.M., Ezelle, H.J., Duverlie, G., Barber, G.N., Levy, D.E., Mukaida, N., Gretch, D.R. (2001). Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-inducing antiviral response. Journal of Virology. 75 (13): 6095-106.

Ezelle, H.J., Markovic, D., Barber, G.N. (2002). Generation of hepatitis C virus-like particles by use of a recombinant vesicular stomatitis virus vector. Journal of Virology. 76 (23):12325-34.

Ferraci, F.*, Day, J.B.*, Ezelle, H.J.*, and Plano, G.V. (2004) Expression of a Functional Secreted YopN-TyeA Hybrid Protein in Yersinia pestis is the Result of a +1 Translational Frameshift Event. Journal of Bacteriology.186(15): 5160-66.

Faria, P.A., Chakraborty, P., Levay, A., Barber, G.N., Ezelle, H.J., Enniga, J., Arana, C., van Deursen, J., and Fontoura, B.M.A. (2005) VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Molecular Cell. 17: 93-102.

Majid, A.M., Ezelle, H., Shah, S., and Barber, G.N. (2006) Evaluating replication-defective vesicular stomatitis virus as a vaccine vehicle. Journal of Virology. 80(14): 6993-7008.

Li, X.L., Andersen, J.B., Ezelle, H.J., Wilson, G.M., and Hassel, B.A. (2007) Post-transcriptional regulation of RNase-L expression is mediated by the 3'untranslated region of its mRNA. Journal of Biological Chemistry. 282 (11): 7950-60.

Ezelle, H.J. and Hassel, B.A. (2007) Mechanisms of IFN Resistance by Influenza Virus. Combating the Threat of Pandemic Influenza: Drug Discovery Approaches. Wiley-Interscience, p73-97.

Okumura, A., Alce, T., Lubyova, B., Ezelle, H., Strebel, K., and Pitha, P.M. (2007) HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. Virology. 30(1):85-97.

Li, X.L., Ezelle, H.J., Kang, T.J., Harro, J., Hasday, J., Crassa, O., Mohapatra, S., Cross, A.S., and Hassel, B.A., An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. PNAS. In Submission.