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Saul Yanovich M.D.

Academic Title: Clinical Professor
Primary Appointment: Medicine
Additional Title(s): Clinical Director, Blood and Marrow Transplantation Program, UMMC
syanovich@umm.edu
Location: UMH Room N9E12
Phone: (410) 328-1320
Phone: (410) 328-1975

Research Interests:

Efficacy and toxicity of allogeneic related and unrelated transplantation.  Management of acute and chronic graft versus host disease.

Abstracts:

Callery, R.T., Strelkauskas, A.J., Yanovich, S., Marks, S.M. The inability of leukemic immunoglobulin negative T-lymphocytes to Cooperate in the production of secreted immunoglobulin.  American Society of Microbiology, May, 1978.

Yanovich, S., Sallan, S., Lazarus, H., Schlossman, S.F.  Surface characteristics of rosette positive acute lymphocytic leukemia.  BLOOD 50(Suppl.):233, 1977.

Yanovich, S., Marks, S., Baseman, S., Rosenthal, D., Moloney, W.E., Schlossman, S.F. Immunologic markers in hairy cell leukemia.  BLOOD 50 (Suppl.):233, 1977.

Silverman, M., Meltz, S., Yanovich, S., Sorokin, C., Glade, P.:  Transfer factor in the treatment of B cell disorders:  Effects and Potential Risks.  J. Clinical Hematology & Oncology 8:124, 1978.

Yanovich, S., Taub, R.N.  Digitized video fluorescence microscopy studies on intracellular daunomycin, AACR 23:172, 1982.

Yanovich, S., Taub, R.N.  Differences in daunomycin uptake and retention in sensitive and resistant murial leukemia cell lines as determined by digitized video fluorescence microscopy (DVFM):  identification of uptake heterogeneity.  AACR 24:758, 1983.

Yanovich, S., Gewirtz, D.  Involvement of calcium in the enhancement of daunomycin accumulation in P388 leukemia cells by Verapamil and calcium ionophore A23187.  AACR 25:1209, 1984.

Shaw, J.M., Yanovich, S., Iwanik, M.J., Shaw, K.V., Wood, R.M.  Lipoproteins as carriers of anthracyclines.  AACR 25:1448, 1984.

Yanovich, S., Gewirtz, D., Weinert, C.  Cellular pharmacokinetics of daunorubicinol.  AACR 26:877, 1985.

Yanovich, S., Gewirtz, D.  Correlation of Daunorubicin uptake and retention into human leukemic cells with clinical response.  AACR 26:707, 1985.

Yanovich, S., Gewirtz, D.  Effects of Vincristine on Daunorubicin retention by resistant P388 cells.  AACR 26:1409, 1985.

Gewirtz, D.A., Yanovich, S.  Metabolism of adriamycin and daunorubicin in hepatocytes from the rat and the rabbit.  AACR 27:954, 1986.

Yanovich, S., Weinert, C., Hall, R.H.  Altered susceptibility of a pleiotropic drug resistance K562 cell line to natural killer cell-mediated lysis.  AACR 27:1037, 1986.

Munger, C., Yanovich, S., and Gewirtz, D.:  Interaction of daunorubicin with the H-35 rat hepatoma.  AACR 28:1987.

Yanovich, S., Gewirtz, D., and Hall, R.H.:  Resistance to natural killer cell lysis is associated with multiple drug resistance.  AACR 29:1082, 1988.

Woods, K., Ellis, A., Conway, B., Randolph, J., Yanovich, S.  Interaction of idarubicin and mitoxantrone with the H-35 rat hepatoma.  AACR 1988.

Ellis, A.L., Gewirtz, D.A., Munger, C., Woods, K.E., Randolph, J.K., Boise, L., and Yanovich, S. Multifactorial drug resistance in the rat hepatoma.  AACR1989.

Yanovich, S., Gewirtz, D., Hall, R.E., Pickard, P., Boise, L. and Westin, E.  Reactivity and functional properties of a monoclonal antibody developed against an MDR K562 subline.  AACR 1989.

Gewirtz, D.A., Ellis, A.L., Randolph, J.K., Yanovich, S., Swerdlow, P. and Povirk, L.  Expression of protein-associated DNA damage in the alkaline elution assay without proteinase K.  AACR 1989.

Yanovich, S., Merten, S., Nelms, P. and Grant, S.  Characterization of a multi-drug resistant (MDR) human erythroleukemia cell line (K562) exhibiting cross-resistance to 1-¿-D-arabinofuranosylcytosine (ara-C).  ASH 1992.

Gewirtz, D.A., Grant, S., and Yanovich, S.  Influence of magainin peptides on sensitivity of K562 leukemic cells and normal bone marrow cells to daunorubicin.  Proc. Am. Assoc. Cancer Res. 33:3127, 1992.

Woods, K.E., Grant, S., Yanovich, S. and Gewirtz, D.A.  Stimulation of normal hematopoietic progenitor cell growth and effects on sensitivity to doxorubicin. Proc. Amer. Ass. Cancer Res. 34:283, 1993.

O’Rourke, M., Crawford, J., Schiller, J., Laufman, L., Yanovich, S., Ozer, H., Langleben, A., Berlogies, B., Koletsky, A., Clamon, G., et al.  Survival advantage for patients with Stage IV NSCLC treated with single agent Navelbine in a randomized controlled trial.  Proc. Amer. Soc. Clin. Oncol. 12:1148, 1993.

Smith, TJ., Buonaiuto, DA., Hillner, BE., Desch, CE., Yanovich, S., Edwards, R. The learning curve for cost of autologous bone marrow transplantation (ABMT) for breast cancer.  Proc. Amer. Soc. Clin. Oncol. 12:54, 1993.

Grant, S., Nelms, P., Yanovich, S.  Characterization of a human multidrug-resistant            (MDR) erythroleukemia subline (K562R) exhibiting cross-resistance to 1-B-D-                  arabinosylcytosine (ara-C).  Proc. Amer. Ass. Cancer Res. 34:1853, 1993.

Fay, J.W., Felser, J.M., Abboud, C., Borson, R., Freytes, C., Herzig, R., Hurd, D., Janakiraman, N., Jensen, J., Lazarus, H., Lynch, J.P., Mengen, K.R., Seez, R., Stevens, D.A., Wolff, S.N., Yanovich, S., and Stiff, P.  Sequential administration of recombinant human interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) after autologous bone marrow transplantation (BMT) therapy for lymphoma:  Results of a phase III multi-center study.  ASH, 1995.

Carr, M.E., Jr, Carr, S.L., and Yanovich, S.  Is platelet dysfunction clinically significant in stem cell disorders?  Abnormal platelet aggregation with normal force development in essential thrombocytosis.  ASH 1995.

Howe C, Wagner J, Kernan N, Hurd D, Bishop M, Gingrich R, Kurtzberg J, Casper J, Henslee-Downey J, Phillips G, Thompson J, Donnenberg A, Long G, Yanovich S.,  and Carter-Campbell S.  T-cell depletion in unrelated-donor marrow transplantation.  ASH 1995.

Smith, T.J., Hillner, B.E., Yanovich, S., Schmitz, N., Lynch, D.C., Boogaerts, M.,              Ferrant A., Link, H. and Zander, A.  Economic Analysis of Peripheral Blood Progenitor      Cell (PBPC) or Autologous Bone Marrow (ABM) Transplant in Relapsed Hodgkin             Disease (HD) and Non-Hodgkin Lymphoma (NHL).  ASCO 1995.

Shea, T., Perry,  J., Brown, R., Yanovich, S., Wiley, Hurd., DiPersio, J., Pope, B., Clapp, K., and Jacobs, C.   A Multi-Center Phase II Trail of CD-34+ Peripheral Blood Stem Cells (PBSC) and High Dose Cyclophospamide (CY), VP-16 Carboplatin (CB) and Total Body Irridation (TBI) for Recurrent Non-Hodgkins Lymphoma (NHL).  ASH 1996.

Becker, J., Tan, J., Kinder, H., and Yanovich, S.   Evaluation of Interset Offset in Fenwal CS3000 on Granulocyte Collection Efficiency and Donor Counts.  ASH, 1996.

Ben-Ezra, J., Becker, J. and Yanovich, S.  Factors Affecting Stem Cell Yield in Breast Cancer Patients Undergoing Peripheral Cell Harvest.  ASH 1996.

Alcorn, K., Lehman, C., Kinder, H., Edwards, R., and Yanovich, S.  CD34 Positive Cell    Selection and T Cell Depletion of Peripheral Blood Stem Cell Collections:  A Comparison of the Baxter Isolex 300SA and 300i Systems.  ASH 1996.

Laport, GF, Bensinger, W., Daugherty, CK., Yanovich, S., Cornetta, K., et al.  A pilot study of allogeneic CD34+ peripheral blood stem cell transplantation (PBSCT) using mismatched related donors for patients with advanced hematologic malignancies. ASH 482, 1997.

Glaspy, J., Lu, ZJ., Wheeler, C., Brown, R., Shea, T., Mangan, K., LeMaistre, C., Long, G., Pecora, A., Yanovich, S., Erder, M.H., Chan, W and Shpall, E.J.  ASH 1646, 1997.

Shpall, EJ., Wheeler, CA., Turner, SA., Yanovich, S., Brown, RA., Pecora, AL., Shea,TC.Mangan, KF., Williams, SF., LeMaistre, CF., Long, GD., et al.  ASH: 2627, 1997.

LeMaistre, C.F., Shpall, E.J., Turner, C.A., Wheeler, C.A., Yanovich, S. et al. ISAGE, 1998.

Pahz, S., Yanovich, S., et al. Quantitative CMV PCR for Monitoring Bone Marrow Transplant (BMT) Recipients for CMV Disease. AMP: ID5, 1998.

Cornetta, K., Yanovich, S., et al.  High dose chemotherapy and stem cell transplant in breast cancer: a randomized multicenter study of CD34 selection.  ASBMT 2000.

Schiller, G, Pecora, A, Yanovich, S et al. Rapid Engraftment in Recipients of CD34-Selected PBSC Transplants from Matched Related Donors: A Randomized Study of Cyclosporine/Methotrexate or Cyclosporine Plus T-Cell Depletion for GVHD Prophylaxis. ASH: 1743, 2001.

Emmanouilides Christos, Spielberger Ricardo, Stiff Patrick, Rong Alan, Isitt John, Bensinger William, Weisdorf Daniel, Gentile Teresa, Kewalramani Tarun, Shea Thomas, Yanovich Saul, et al.  Palifermin Treatment of Mucositis in Transplant Patients Reduces Health Resource Use: Phase 3 Results. ASH 883 abs, 2003.

Pavletic Steven Z, Carter Shelly L, Weisdorf Daniel, Henslee-Downey Jean, Papadopoulos Esperanza, Gingrich Roger, Casper James, Kernan Nancy A, Yanovich Saul.  No Benefit of 1log T-Cell Depletion on Chronic Graft vs. Host Disease (cGVHD): Results of a Multi-Center Randomized Trial in 404 Recipients of Unrelated Donor Bone Marrow Transplantation (UBMT). ASH 530 abs, 2003.

Stiff Patrick, Bensinger William, Emmanouilides Christos, Gentile Teresa, Weisdorf Daniel, Shea Thomas, Yanovich Saul, et al. Treatment of Mucositis with Palifermin Improves Patient Function and Results in a Clinically Meaningful Reduction in Mouth and Throat Soreness (MTS): Phase 3 Results. ASH 676 abs, 2003.

Bensinger W, Weisdorf D, Gentile T, Cesano A, Elhardt D, Emmanouilides C, Erder MH, Hansen K, Isitt J, Kewalramani T, McCarty J, Noga S, Rong A, Shea T, Spielberger R, Yanovich S, Stiff P.  Palifermin reduces severe oral mucositis (OM), improves patient quality of life, and reduces health resource use in patients with hematologic malignancies receiving high-dose chemotherapy (HDCT) and total body irradiation (TBI) with autologous peripheral blood stem cell (PBSC) support: Results from a phase III trial.Biology of Blood and Marrow Transplantation February 2004, Supplement • Vol 10 • Number 1 • p. 31.


Publications:

Marks, S.M., Yanovich, S., Rosenthal, D.S., Moloney, W.E., Schlossman, S.F.  Multimarker analysis of T-chronic lymphocytic leukemia.  Blood 51:435-438, 1978.

Yanovich, S., Marks, S.M., Rosenthal, D.S., Moloney, W.E., Schlossman, S.F.:  Cell surface characteristics of hairy cell leukemia in seven patients.  Cancer 43:2348-2351, 1979.

Yanovich, S., Harris, K., Sallen, S.E., Schlossman, S.F., Inbar, M.  Dynamic parameters of membrane lipids in normal and leukemic human lymphocytes isolated from peripheral blood and bone marrow.  Cancer Research 38:4654-4661, 1978.

Rosenthal, K.S., Yanovich, S., Inbar, M., Strominger, J.L.  Translocation of a hydrocarbon fluorescent probe between Epstein-Barr Virus and Lymphoid Cells:  An assay for early events in viral infection.   Proc. Natl. Acad. Sci. U.S.A. 75:5076-5080, 1978.

Callery, R.T., Strelkauskas, A.J., Yanovich, S., Marks, S.., Schlossman, S.F.  Functional abnormalities associated with T. lymphocytes from patients with chronic lymphocytic leukemia.  Clin. Immunol. Immunopathol. 17:451-458, 1980.

Hoover, R.L., Bhalla, D.K., Yanovich, S., Inbar, M., Karnovsky, M.J.  Effects of linoleic acid on capping, lectin mediated mitogenesis, surface antigen expression, and fluorescent polarization in lymphocytes and BHK cells:  J. of Cell Phys. 103:399-406, 1980.

Yanovich, S., Taub, R.N.  Digitized video fluorescence microscopy studies of intracellular adriamycin:  Cancer Research 42:3583-3586, 1982.

Yanovich, S., Taub, R.N.:  Differences in daunomycin retention in sensitive and resistant murine leukemia cells as determined by digitized video fluorescence microscopy.  Cancer Research, 43:4167-4171, 1983.

Yanovich, S., and Preston, L.  Effects of verapamil on daunomycin cellular retention and cytotoxicity in P388 leukemic cells.  Cancer Research 44:1743-1747, 1984.

Iwanik, M.J. Shaw, K.V., Ludwith, B., Yanovich, S. and Shaw, J.M.  Preparation and interaction of a low density lipoprotein-daunomycin complex with P388 leukemia cells.  Cancer Research 44:1206-1215, 1984.

Yanovich, S., Preston, L., and Shaw, J.M.  Characteristics of uptake and cytotoxicity of a low density lipoprotein-daunomycin complex in P388 leukemia cells.  Cancer Research 44:3377-3382, 1984.

Yanovich, S., Hall, R.E., Weinert, C.  Resistance to Natural Killer Cell-Mediated Cytolysis by a Pleiotropic Drug Resistant Human Erythroleukemia (K562-R) Cell line.  Cancer Research 46:4511, 1986.

Gewirtz, D.A. and Yanovich, S.  Metabolism of the Anthracycline Antibiotic Daunorubicin to Daunorubicinol and Deoxydaunorubicinol Aglycone in Hepatocytes isolated from the Rat and the Rabbit.  Biochemical Pharmacology 35:4059, 1986.

Gewirtz, D.A., and Yanovich, S.  Metabolism of Adriamycin in hepatocytes isolated from the rat and the rabbit.  Biochemical Pharmacology 36:1793-1798, 1987.

Barcelo, F., Barcelo, I., Ferragot, J.A., Gavilances, F., Yanovich, S., and Gonzalez Ros, J.M. Interaction of anthracyclines with nucleotides and related compounds: A spectroscopy study.  Biochem. Biophys. Acta 884:172, 1986.

Shaw, J. M., Shaw, K.V., Yanovich, S., Iwanik, M., Futch, W.S., Rosowsky, A., and Schook, L.B.  Delivery of lipophilic drugs using lipoproteins.  Annals New York Academy of Sciences 1987.

Munger, C., Ellis, A., Woods, K., Randolph, J., Yanovich, S., and Gewirtz, D.  Interaction of Daunorubicin with the H-35 rat hepatoma: evidence for inhibition of growth related to compromised DNA synthesis.  Cancer Res. 48:2404, 1988.

Yanovich, S., Hall, R.E. and Gewirtz, D.  Characterization of a human K562 drug resistant cell line. Cancer Res. 49:4499-4503, 1989.

Gewirtz, D.A., Ellis, A.L., Randolph, J., and Yanovich, S, et al.  Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.  Cancer Communications 1:175, 1989.

Szucs RA, Rehr RB, Yanovich S, Tatum JL.  Magnetic resonance imaging of cardiac rhabdomyosarcoma. Quantifying the response to chemotherapy.  Cancer 67:2066-70, 1991.

Gewirtz, D.A., Munger, C.E., Ellis, A.L., Woods, K.E., Randolph, J.K., Boise, L., Swerdlow, P., and Yanovich, S.  Components of intrinsic drug resistance in the rat hepatoma.  Biochemical Pharmacology 43:331-342, 1992.

Ellis, AL., Munger, CE., Bunch, RT., Woods, KE., Randolph, JK., Boise, L., Swerdlow, PS., Zwelling, LA., Hinds, M., Yanovich, S., et al.  Biochem. Pharmacol. 42: 331-342, 1992.

Woods, K.E., Grant, S., Yanovich, S. and Gewirtz, D.A. Variable effects of tamoxifen on human hematopoietic progenitor cell growth and sensitivity to doxorubicin. Cancer Chemotherapy and Pharmacology 33:509-514, 1994.

Grant S, Nelms P, Yanovich S.  Characterization of a multidrug resistant human erythroleukemia cell line (K562) exhibiting cross-resistance to 1-¿-D arabinofuranosylcytosine.  Leukemia 9:808-814, 1995.

Grant, S., Freemerman, A.J., Gregory, P.C., Martin, H.A., Turner, A.J., Mikkelsen, R., Chelliah, J., Yanovich, S. And Jarvis, W.D.  Induction of Apoptotic DNA Fragmentation and c-jun Down-regulation in Human Myeloid Leukemia Cells by the permeant Ca2+ Chelator BAPTA/AM.  Oncology Research 7:381-392, 1995.

Gandara DR, Nahhas WA, Adelson MD, Lichtman SM, Podczaski ES, Yanovich S, Homesley HD, Braly P, Ritch PS, Weisberg SR  et al  Randomized placebo-controlled multicenter evaluation of diethyldithiocarbamate for chemoprotection against cisplatin-induced toxicities.  J Clin Oncol 13:490-6, 1995.

Crawford J., O’Rourke, M., Schiller, J.H., Harris Spiridonitis C., Yanovich S., Ozer H., Langleben A., Hutchins L., Koletsky A., Clamon G., Burman, S., White R., and Hohneker J.  Randomized Trial of Vinorelbine Compared with Fluorouracil Plus Leucovorin in Patients with Stage IV Non-Small Cell Lung Cancer.  J Clin Oncol 14: 2774-2784, 1996.

Smith, T.J., Hillner, B.E., Schmitz, N., Lynch, D.C., Dreger P., Goldstone, M.A., Boogaerts, M., Ferrant A., Link, H. and Zander, A., Yanovich, S., Kitchin, R., and Erder, M.H..  Economic Analysis of a Randomized Clinical Trial to Compare Filgrastim Mobilized Peripheral Blood Progenitor Cell Transplantation and Autologous Bone Marrow Transplantation in Patients with Hodgkin Disease and Non-Hodgkin Lymphoma.  J Clin Oncol 15: 5-10, 1997.

Chabannon, C., Cornetta, K., Lotz, JP., Rosenfeld, C., Shlomchik, M., Yanovich, S. et al. High-Dose Chemotherapy Followed by Reinfusion of Selected CD34+ Peripheral Blood Cells in Patients with Advanced Breast Cancer: A Randomized Multicenter Study. British Journal of Cancer 78: 913-921, 1998.

Shpall, EJ., Wheeler, CA., Turner, SA., Yanovich, S., et al.  A Randomized Phase 3 Study of PBPC Mobilization by Stem Cell Factor and Filgrastim in Patients with High-Risk Breast Cancer.  Blood 93: 2491-2501, 1999.

Whitehurst, M.M, Aldenderfer, P.H., Yanovich, S. and Strelkauskas, A.J. Clinical Analysis of the Novel Breast Cancer Serum Assay BT1.  Anticancer Research 19(2A): 1331-5, 1999.

Ferreira-Gonzalez, Yanovich, S., et al. Enhanced analytical sensitivity of a quantitative PCR for CMV using a modified nucleic-acid extraction procedure.  Journal of Clinical Laboratory Analysis 14: 32-37, 2000.

Yanovich, S., Mitsky, P, et al.  Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial.  Bone Marrow Transplantation 25: 1165, 2000.

Burgess, J., Mills, B., Griffith, M., Mansour, V., Weaver, C., Scwartzberg, L., Snyder, E., Krause, DS., Yanovich, S., Prilutskaya, M., Moss, TJ.  Breast tumor contamination of  PBSC harvests: tumor depletion by positive selection of CD34 (+) cells. Cytotherapy 3: 285, 2001.

Walsh, TJ., Pappas, P., Winston, D., Blume, J., Petersen, F., Rafalli, J., Yanovich, S., et al. Voriconazole versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Persistently Febrile Neutropenic Patients.  N Engl J of Med 346: 225, 2002.

Spielberger Ricardo, Stiff Patrick, Bensinger William, Gentile Teresa, Weisdorf Daniel, Kewalramani Tarun, Shea Thomas, Yanovich Saul, et al.  Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers. N Engl J Med 2004;351:2590-8.

Tutuncuoglu O, Yanovich S and Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 36: 265-266; 2005.

Pavletic Steven Z, Carter Shelly L, Kernan Nancy A, Henslee-Downey Jean, Mendizabal  Adam M, Papadopoulos Esperanza, Gingrich Roger, Casper James, Yanovich Saul and Weisdorf Daniel.  Influence of T cell depletion on chronic Graft-Versus-Host Disease: results of a multi-center randomized trial in unrelated marrow donor transplantation.Blood 2005; 106: 3308 - 3313.

de Lissovoy G, Hurd D, Carter S, Beatty P, Ewell M, Henslee-Downey J, Kernan N, Yanovich S,  Weisdorf D .   Economic analysis of unrelated allogeneic bone marrow transplantation: results from the randomized clinical trial of T-cell depletion vs. unmanipulated grafts for the prevention of graft-versus-host disease. Bone Marrow Transplant 2005; 36:539-46.
 
Altmaier, E., Davies, S, Geller, N., Gingrich, R., Yanovich, S. et al.   The Effect of Unrelated-donor Marrow Transplantation on Health-Related  Quality of Life:  A Report of the Unrelated Donor Marrow Transplantation Trial    (T Cell Depletion Trial).Biology of Blood and Marrow Transplantation (in press).