Dr. Mehra sub-specializes in the field of advanced heart failure and cardiac transplantation. He has published more than 350 articles on advanced heart failure and cardiac transplantation, including various treatment modalities and alternatives to transplantation. His specific research interests in cardiac transplantation focus on post-transplant coronary arterial disease, new immunosuppressive therapy to improve heart transplant outcomes, and bringing genomic and proteomic science (the study of protein interactions in the body) to the bedside. In the field of heart failure, his research has focused on the role of new devices and novel serum markers (BNP) to guide diagnosis and therapy.
Dr. Mehra holds several international leadership positions, including his service on the board of directors of the International Society for Heart and Lung Transplantation, the education committee of the Heart Failure Society of America and as Chair of the Thoracic Committee of the American Society of Transplantation. Additionally, he serves as an associate editor for four prestigious academic journals, including the American Journal of Transplantation, Journal of Heart and Lung Transplantation, Journal of Cardiac Failure and the Mayo Clinic Proceedings, and as an editorial consultant for the Journal of the American College of Cardiology.
Specific Research Interests:
• Intravascular ultrasound and Intracoronary angioscopy analysis for cardiac allograft vasculopathy in heart transplantation
• Novel immunosuppression strategies to enhance survival in African-American heart transplant recipients and address renal dysfunction post transplant
• Molecular gene expression diagnostics for detection of rejection and prediction of outcomes in heart transplantation
• Percutaneous Continuous Aortic Flow Augmentation in advanced heart failure
• Biomarkers in heart failure and transplantation (BNP) and cardiopulmonary stress testing in heart failure.
• Development of international guidelines for the care of the heart transplant candidate and process enhancement for improving performance measure adherence in heart failure
Selected References (past 12 months)
Ventura HO, Mehra MR. Bloodletting as a cure for dropsy: Heart failure down the ages. J Card Fail 2005: 11(4):247-52.
Kadish AH, Mehra MR. Heart Failure Devices I:AICD (ICD) and biventricular pacing. Circulation:111:3327-3335, 2005.
Wu AH, Ballantyne CM, Short BC, Torre-Amione G, Young JB, Ventura HO, Eisen HJ, Radovancevic B, Rayburn BK, Lake KD, Yancy CW, Taylor DO, Mehra MR, Kubo SH, Fishbein DP, Zhao XQ, O’Brien KD. Statin use and risks of death or fatal rejection in the heart transplant lipid registry. Am J Cardiol. 1;95(3):367-372, 2005
Kobashigawa JA, Tobis JM, Starling RC, Tuzcu EM, Smith AL, Valantine HA, Yeung AC, Mehra MR, Anzai H, Oeser BT, Abeywickrama KH, Murphy J, Cretin N. Multicenter Intravascular Ultrasound (IVUS) Validation Study Among Heart Transplant Recipients: Outcomes After 5 Years. J Am Coll. Cardiol May 3;45(9):1532-7, 2005.
Mehra MR, Uber PA, Prasad A, Scott RL, Park MH. Recrudescent tobacco exposure following heart transplantation: clinical profiles and relationships with athero-thrombosis risk markers. Amer J of Transplantation May:5(5):1137-40, 2005.
Mehra MR, Maisel A. B-type natriuretic peptide in heart failure: diagnostic, prognostic and therapeutic utility. Critical Pathways in Cardiology March;4(1):10-20, 2005.
Ventura HO, Mehra MR. The interaction of vascular stiffness and cardiovascular events in women: insights from the heart and estrogen/progestin replacement study (HERS). Chest May;127(5):1477-80, 2005.
Evans RW, Williams GE, Baron HM, Deng MC, Eisen HJ, Hunt SA, Khan MM, Kobashigawa JA, Marton EN, Mehra MR, Mital SR. The economic implications of noninvasive molecular testing for cardiac allograft rejection. Amer J of Transplantation May;5:1553-1558, 2005.
Eisen HJ, Kobashigawa J, Keogh A, Bourge R, Renlund D, Mentzer R, Alderman E, Valantine H, Dureau G*, Mancini D, Mamelok R, Gordon R, Wang W, Mehra M, Constanzo MR, Hummel M, Johnson J. Three-year results of a randomized double-blind, controlled trial of mycophenolate ofetil vs azathioprine in cardiac transplant recipients. J Heart Lung Transplant 2005 2005 May;24(5):517-25.
Strickberger SA, Conti J, Daoud EG, Havranek E, Mehra MR, Pina IL, Young J. Patient Selection for Cardiac Resynchronization Therapy. Circulation;111:2146-2150, 2005.
Potluri S, Mehra MR, Uber PA, Park MH, Scott RL, Ventura HO. The relationship between epicardial coronary disease, tissue myocardial perfusion and survival in heart transplantation. J Heart Lung Transplant.;24:1019-25, 2005.
Marboe CC, Billingham M, Eisen H, Deng MC, Baron H, Mehra MR, Hunt S, Wohlgemuth J, Mahmood I, Prentice J, Berry G. Nodular Endocardial Infiltrates (Quilty Lesions) Cause Significant Variability in Diagnosis of ISHLT Grade 2 and 3A Rejection in Cardiac Allograft Recipients. J Heart Lung Transplant. July;24(7S):S219-S226, 2005.
Mehra MR.. The Emergence of Genomic and Proteomic Biomarkers in Heart Transplantation. J Heart Lung Transplant. July;24(7S):S213-S218, 2005.
Mehra MR, Zucker MJ, Wagoner L, Michler R, Boehmer J, Kovarik J, Vasquez A. A multicenter, prospective, randomized, double-blind trial of basiliximab in heart transplantation. J Heart Lung Transplant Sept.;24(9):1297-304, 2005.
Hauptman PJ, Mehra MR. It Is Time To Stop Ignoring Malignancy In Heart Transplantation: A Call To Arms. J Heart Lung Transplant 2005;24:1111-3
Mehra MR, Griffith BP. Is mitral regurgitation a viable treatment target in heart failure? The plot just thickened. J Am Coll Cardio 2005 45(3):388-90
Ventura HO, Mehra MR. Improvement Of heart failure following renal transplantation: The complex maze of cardio-renal interaction. J Am Coll Cardio 2005 April 5;45(7):1061-3
Deng MC, Eisen HJ, Mehra MR, Billingham M, Marboe CC, Berry G, Kobashigawa J, Johnson FL, Starling RC, Murali S, Pauly DF, Baron H, Wohlgemuth JG, Woodward RN, KlinglerTM, Walther D, Lal PG, Rosenberg S, Hunt S, for the CARGO Investigators. Amer J of Transplantation 2006;6(1):150-160
Mehra MR. Optimizing outcomes in the patient with acute decompensated heart failure. Am Heart J 2006;151:571-9
Milani RV, Lavie CJ, Mehra MR, Ventura HO, Kurtz J, Messerli FH. Left Ventricular Geometry and Survival in Patients with Preserved Left Ventricular Ejection Fraction. Am J Cardiol 2006:97:959-963.
Packer M, Abraham WT, Mehra MR , Yancy C , Lawless CE, Mitchell J , Bijou R , O'Connor C, Massie B, et al. Utility Of Impedance Cardiography For The Identification Of Short-Term Risk Of Clinical Decompensation In Stable Patients With Chronic Heart Failure. J Am Coll Cardio 2006 (in press 6-6-06)
Greenberg B, Mehra MR. All patients with heart failure and intraventricular conduction defect or dyssynchrony should receive cardiac resynchronization therapy (CRT)-Antagonist View. Circulation 2006 (in press)
Mehra MR, Uber PA, Walther D, Vesely M, Wohlgemuth J, Prentice J, Tayama D, Billingham, M. Gene Expression Profiles And B-Type Natriuretic Peptide Elevation In Heart Transplantation: More Than A Hemodynamic Marker. Circulation 2006 (in press)
Mehra MR, Feller E, Rosenberg S. The promise of protein-based and gene-based clinical markers in heart transplantation: from bench to bedside. Nat Clin Pract Cardiovasc Med. 2006 March;3(3):136-43
Thorn EM, Mehra MR. Imaging Markers of Adverse Remodeling: From Organ to Organelle. Heart Failure Clinics 2006 (in press)
Mehra MR, Lavie CJ, Ventura HO, Milani RV. Fish Oils Produce Anti-inflammatory Effects and Improve Body Weight In Severe Heart Failure. J Heart Lung Transplant 2006 (in press)
Mehra MR, Uber PA, Kaplan B. Immunosuppression In Cardiac Transplantation: Science, Common Sense And The Heart Of The Matter. Am J Transplant 2006 (in press)
Kobashigawa JA, Starling RC, Mehra MR, Kormos R, Bhatt G, Barr ML, Sigouin CS, Kolesar J, Fitzsimmons W. Multi-center retrospective analysis of cardiovascular risk factors affecting outcome of de novo cardiac transplant recipients. J Heart Lung Transplant 2006 (in press)
Lavie CJ, Mehra MR, Milani RV. Obesity and Heart Failure Prognosis–Paradox or Reverse Epidemiology? Europ Heart J 2005 26(1):5-7
Mitchell JA, Ventura HO, Mehra MR. Early Recognition and Treatment of Hypertensive Heart Disease. Curr Opin Cardiol. 2005 Jul:20(4):282-9
Deng MC, Eisen HJ, Mehra MR. Methodological challenges of genomic research-the cargo study. Am J Transplant. 2006 May;6(5):1086-7.
Kobashigawa JA, Tobis JM, Mentzer RM, Valantine HA, Bourge RC, Mehra MR, Smart FW, Miller LW, Tanaka K, Li H, Gjertson DW, Gordon RD. Mycophenolate mofetil reduces intimal thickness by intravascular ultrasound after heart transplant: reanalysis of the multicenter trial. Am J Transplant. 2006 May;6(5):993-7.
Mehra MR. Contemporary concepts in prevention and treatment of cardiac allograft vasculopathy. Am J Transplant.2006 (Online publication date: 23-Mar-2006)