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Personal History
Dr. Kwok received his BA in Psychology from Johns Hopkins University in 1995. He received his MD from Albert Einstein College of Medicine (New York) in 1999. He completed an internship in Internal Medicine at Beth Israel Medical Center (New York) in 2000, before commencing his residency in Radiation Oncology at the University of Maryland Medical Center, which he completed in 2004. Dr. Kwok then joined the Department of Radiation Oncology at the University of Maryland School of Medicine as an Assistant Professor in 2004.Research Interests
Clinical Speciality
Dr. Kwok’s clinical specialty includes genito-urinary tumors, such as prostate and bladder cancer, as well as brain and base-of-skull tumors, and pediatric tumors.
Current Grant Support:
Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and Long-Term Hormonal Ablation in Patients with High Risk, Non-Metastatic Prostate Cancer.
Role: PI
Radiation Oncology Pilot Project Award, Univ of Maryland
Neuroimaging Correlates in Evaluating Cognitive Function Following Radiation Therapy
Role: Co-Investigator
Radiation Oncology Pilot Project Award, Univ of Maryland
Radiosensitizing Effect of Histone Deacetylase Inhibitors for the Treatment of Glioblastoma Multiforme with Low-Dose Fractionated Radiation Therapy (LDFRT) in Combination with Radiation Therapy
Role: Co-PI
Active Clinical Trials:
Publications
JOURNAL ARTICLES
Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. International Journal of Radiation Oncology Biology Physics 2002, 53(3), 588-594.
Flannery T, Suntharalingam M, Kwok Y, Koffman B, Amin P, Chin L, Nicol B, Fowler B, Young AB, Regine W. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer 2003, 42, 327-333.
Thomas L, Kwok Y, Edelman M. Management of paraneoplastic syndromes in lung cancer. Current Treatment Options in Oncology 2004, 5(1), 51-62.
Herman JM, Petit JH, Amin P, Kwok Y, Dutta P, Chin LS. Repeat gamma knife radiosurgery for refractory or recurrent trigeminal neuralgia: Treatment outcomes and quality of life assessment. International Journal of Radiation Oncology Biology Physics 2004, 59(1), 126-133.
Garofalo M, Kwok Y, Regine WF. The Evolving Role of Adjuvant Postoperative Radiation Therapy. Surgical Oncology Clinics of North America 2004 Oct;13(4):589-604, viii.
Patel AB, Edelman MJ, Kwok Y, Krasna M, Suntharalingam M. Predictors of acute esophagitis in patients with non-small cell lung carcinoma treated with concurrent chemotherapy and hyperfractionated radiation therapy followed by surgery. International Journal of Radiation Oncology Biology Physics 2004 Nov;60(4),1106-12.
DiBiase S, Kwok Y, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. International Journal of Radiation Oncology Biology Physics 2004 Nov 15;60(4):1106-12.
Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. International Journal of Radiation Oncology Biology Physics 2005 Jun 1;62(2):618-9.
Kwok Y, Regine WF, Patchell RA. Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. Journal of Clinical Oncology 2005 May 20;23(15):3308-10. Epub 2005 Feb 28.
Yovino S, Kwok Y, Krasna M, Bangalore M, Suntha M. An association between preoperative anemia and decreased survival in early-stage non-small cell lung cancer treated with surgery alone. International Journal of Radiation Oncology Biology Physics 2005 Aug 1;62(5):1438-4.
Ma L, Kwok Y, Chin LS, Simard JM, Regine WF. Concomitant GRID boost for Gamma Knife radiosurgery. Medical Physics 2005 Nov;32(11):3419-23.
Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol 2005 Nov 21;50(22):5217-27. Epub 2005 Oct 24.
D’Souza W, Kwok Y, DeYoung C, Zacharapoulos N, Pepelea M, Klahr P, and Yu CX. Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry. Medical Physics 2005 Dec;32(12):3641-49.
Kwok Y, DeYoung C, Garofalo M, Dhople A, and Regine W. Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America April 2006;20(2):505-522.
Kwok Y, Patchell RA. Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al. Oncology May 2006;20(6):619-625.
Kwok Y, Tibbs PA, Patchell RA. Clinical approach to metastatic epidural spinal cord compression. Hematology/Oncology Clinics of North America Dec 2006;20(6):1297-1305.
D’Souza W, Nazareth D, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, and Regine W. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Medical Dosimetry 2007 Summer;32(2):92-101
Dhople A, Kwok Y, Chin L, et al. Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery. Int J Radiat Oncol Biol Phys 2007;69(2):397-403. Epub 2007 Apr 30.
Flannery TW,Suntharalingam M, Regine WF, Chin LS, Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, and Kwok Y. Long-term survival in patients with synchronous, solitary brain metastasis from non-small cell lung cancer treated with radiosurgery. Int J Radiat Oncol Biol Phys 2008 Sept 1;72(1):19-23. Epub 2008 Feb 13. [senior author]
Dhople AA, Adams JR, Maggio WW, Naqvi SA, Regine WF, and Kwok Y. Long Term Outcomes of Gamma-Knife Radiosurgery for Classic Trigeminal Neuralgia: Implications of Treatment and Critical Review of the Literature. J Neurosurg 2009: 1-8. Epub 2009 March 27. [senior author]
Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Carter K, Ord R, Zimrin A, Strome S, and Suntharalingam M. Race impacts outcome in stage III/IV squamous cell carcinomas of the head and neck after concurrent chemoradiation therapy. Cancer 2009; 115(8):1744-52.
Yovino S, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome S,and Suntharalingam M. Patterns of failure among patients with squamous cell carcinoma of the head and neck who obtain a complete response to chemoradiotherapy. Head Neck Head Neck 2010;32(1):46-52. Epub 2009 May 29.
Kwok Y, Yovino S. Radiation-based therapies for prostate cancer. Curr Opin Oncol 2010 May;22(3):257-62.
DiBiase SJ, Hussain A, Kataria R, Amin P, Bassi S, Dawson N, and Kwok Y. Long-term results of a prospective, phase II study of long-term androgen ablation, pelvic radiotherapy, brachytherapy boost and adjuvant docetaxel in patients with high-risk prostate cancer. In Press. International Journal of Radiation Oncology Biology Physics 2010.
Hussain A, Wu Y, Mirmiran A, DiBiase S, Goloubeva O, Bridges, Mannuel H, Engstrom C, Dawson N, Amin P and Kwok Y. Long-term follow-up of a prospective trial of trimodality therapy of weekly paclitaxel, radiation and androgen deprivation in high risk prostate cancer with or without prior prostatectomy. In Press. International Journal of Radiation Oncology Biology Physics 2010.
Szerlip N, Rutter C, Ram N, Yovino S, Kwok Y, Maggio W, Regine W. Factors impacting volumetric white matter changes following whole-brain radiation therapy. Journal of Neuro-Oncology 2010 Aug 20. [Epub ahead of print]
Koshy M, Rich SE, Mahmood U, Feigenberg S, and Kwok Y. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. In Press. International Journal of Radiation Oncology Biology Physics 2011.
Suntharalingam M, Kwok Y, Goloubeva O, Parekh A, Taylor R, Wolf J, Zimrin A, Strome S, Ord R, and Cullen K. A Phase II Study Evaluating the Addition of Cetuximab to the Concurrent Delivery of Weekly Carboplatin, Paclitaxel and Daily Radiotherapy for Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck. In Press. International Journal of Radiation Oncology Biology Physics 2011.
Koshy M, Rich S, Merchant E, Mahmood U, Regine W, and Kwok Y. Post-operative Radiation Improves Survival in Children Younger Than 3 Years with Intracranial Ependymoma. Journal of Neuro-oncology 2011 June 3. [Epub ahead of print]
Non-refereed
Kwok Y, Patchell RA. Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al. Oncology May 2006;20(6):619-625.
BOOK CHAPTERS
Kwok Y, Garofalo M, Regine WF. "Postoperative Adjuvant Therapy for Pancreatic Cancer". In: Pancreatic Cancer. Von Hoff DD, Evans DB, and Hruban RH (ch.27, p395-404). Sudbury, MA: Jones and Barlett, 2005.
Kwok Y, Patchell RA, Regine WF. "Palliation of Brain and Spinal Cord Metastases" In: Principles and Practice of Radiation Oncology. Lippincott Williams & Wilkins; 5th edition. 2007.
Miker-Zabel S, Kwok Y, Debus J. "Skull Base Tumors" In: Principles and Practice of Stereotactic Radiosurgery (ch.37, p383-392). Springer; 1st edition. 2008
Chin LS, Patel S, Mattingly T, Kwok Y. "Trigeminal Neuralgia" In: Principles and Practice of Stereotactic Radiosurgery (ch.52, p519-526). Springer; 1st edition. 2008
Kwok Y, Patchell RA, Regine WF. "Management of Overt CNS Metastases: Brain and Spinal Cord" Lung Cancer: Principles and Practice. Lippincott Williams & Wilkins; 4th edition. 2010.
Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: ALERT: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Rubin P, Constine L, Marks L, Williams J, Hansen J. New York, NY: Springer-Verlag, July 2012.
Other Brief Communications
Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. International Journal of Radiation Oncology Biology Physics 2005 Jun 1;62(2):618-9.
Kwok Y, Patchell RA, Regine W. In reply to Dr. Macbeth et al and Dr. Maranzano et al. Journal of Clinical Oncology 2005;23(32):8272-8275.
Kwok Y, Patchell RA. Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al. Oncology May 2006;20(6):619-625.
Mahmood U, Kwok Y, Regine WF, and Patchell RA. Whole brain irradiation for patients with brain metastasis: still the standard of care. Lancet Oncol 2010;11(3):221-2.