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Rosemary A Schuh Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Neurology
rschuh@som.umaryland.edu
Location: VAMC, 3C-125
Phone: (410) 605-7000, ext 6498
Fax: (410) 605-7906

Personal History:

Education/Training

  • BS, Life Sciences (Emphasis in Biochemistry), Arizona State University
  • ScM, Toxicology, Johns Hopkins University, Bloomberg School of Hygiene and Public Health
  • PhD, Toxicology, University of Maryland, Baltimore

Research Interests:

  • Alzheimers disease
  • Mitochondrial dysfunction and neurodegenerative disease
  • Environmental exposure (specifically pesticide exposure) and neurodegenerative disease
  • Environmental exposure and mitochondrial dysfunction

Lab Techniques and Equipment:

  • Mitochondrial bioenergetics
  • Fluorescent measurements of cell death
  • Confocal microscopy (laser and CARV)
  • PCR
  • Western blotting and immunohistochemical staining
  • Organotypic hippocampal slice cultures
  • Enzyme activity measurements
  • ELISA Spectrofluorometry

Publications:

Jackson KC, Gidlund EK, Norrbom J, Valencia AP, Thomson DM, Schuh RA, Neufer DP, Spangenburg EE (2014). BRCA1 is a Novel Regulator of Lipid Metabolism in Skeletal Muscle. J. Lipid Res. In Press

Schuh RA, Jackson KC, Schlappal AE, Spangenburg EE, Ward CW, Park JH, Dugger N, Shi GL, Fishman PS (2014). Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer’s disease-relevant murine model. BMC Neurosci. 15(1):24. PMID: 24524276

Owens K, Park J, Schuh, R, Kristian T. (2013). Mitochondrial dysfunction and NAD+ metabolism alterations in the pathophysiology of acute brain injury. Transl Stroke Res. 4(6):618-34. PMID: 24323416

Spangenburg EE, Jackson KC, Schuh RA. (2013). AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture. J. Physiol. Biochem. Epub ahead of print. PMID: 23813470

Jackson KC, Wohlers LM, Lovering RM, Schuh RA, Maher AC, Bonen A, Koves TR, Ilkayeva O, Thomson DM, Muoio DM, Spangenburg EE. (2012). Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. A. J. Physiol. (Reg. Integr. Comp. Physiol.) 304 (3):R206-17. PMID: 23193112 

Goolsby J, Atamas M, Roller S, Asanuma D, Schuh R, Makar T, Fishman PS, Bever CT, Trisler D. (2012). Retinal neuroprogenitors express topographic map markers. Neurochem. Int. 61 (6), 859-865. PMID: 22366647

Schuh RA, Jackson KC, Khairallah RJ, Ward CW, Spangenburg EE. (2011). Measuring mitochondrial respiration in intact single muscle fibers. A. J. Physiol. (Reg. Integr. Comp. Physiol.) 302 (6), R712-719. PMID: 22160545

Kristian T, Balan I, Schuh R, Onken M. (2011) Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection. J. Neurosci. Res. Epub.

Schuh RA, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H, Polster BM. (2011). Adaptation of Microplate-based respirometry for hippocampal slices and analysis of respiratory capacity. J. Neurosci. Res. Epub.

Schuh RA, Richardson JR, Gupta RK, Flaws JA, Fiskum, G. (2009). Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. Neurotoxicology 30, 274-280.

Schuh RA, Matthews CC, and Fishman PS. (2008). Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiate cell death in hippocampal slice cultures. J. Neurosci. Res. 86 (15), 3306-3313.

Soane L, Siegel ZT, Schuh RA, and Fiskum G. (2008). Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res. 86, 1267-1276.

Gupta RK, Schuh RA, Fiskum G, and Flaws JA. (2006). Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicol Appl Phar 216, 436-445.

Schuh RA, Kristián T, Gupta RK, Flaws JA, and Fiskum G. (2005). Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol. Sci. 88 (2), 495-504.

Schuh RA, Kristián T, and Fiskum G. (2005) Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J Neurochem 92 (2), 388-394.

Schuh RA, Lein PJ, Beckles RA, and Jett DA. (2002). Noncholinesterase Mechanisms of Chlorpyrifos Neurotoxicity: Altered Phosphorylation of Ca2+/cAMP Response Element Binding Protein in cultured Neurons. Toxicol Appl Pharmacol 182 (2), 176-185.