Research Interests:Cell-matrix interactions, cell migration, integrins, transglutaminases
Anu Waghray, Assistant Research Professor
Eugene Zemskov, Post Doctoral Fellow
Akimov S.S., D. Krylov, L.F. Fleischman, and A.M. Belkin. (2000). Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J. Cell Biol., 148:825-838.
Belkin, A.M., and M.A. Stepp. (2000). Integrins as receptors for laminins. Microsc. Res. Tech., 51:280-301.
Belkin, A.M., S.S. Akimov, L.S. Zaritskaya, B.I. Ratnikov, E.I. Deryugina, and A.Y. Strongin. (2001). Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. J. Biol. Chem., 276:18415-18422.
Akimov, S.S., and A.M. Belkin. (2001). Cell surface transglutaminase promote fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFb-dependent matrix deposition. J. Cell Sci., 114:2989-3000.
Akimov, S.S., and A.M. Belkin. (2001). Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood, 98:1567-1576.
Akimov, S.S., and A.M. Belkin. (2003). Opposing roles of H-Ras/Raf-1 oncogenes and the MEK1/ERK signaling module in regulation of expression and adhesive function of surface transglutaminase. J. Biol. Chem., 278:35609-35619.
Belkin, A.M., E.A. Zemskov, J. Hang, S.S. Akimov, S. Sikora, and A.Y. Strongin. (2004). Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis. Biochemistry, 43:11760-11769.
Belkin A.M, G. Tsurupa, E. Zemskov, Y. Veklich, J.W. Weisel, and L. Medved. (2005). Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC-domains promotes integrin-dependent cell adhesion and signaling. Blood, 105:3561-3568.
Hang, J., E. Zemskov, L Lorand, and A.M. Belkin. (2005). Identification of a novel recognition sequence for fibronectin within the NH2-terminal beta-sandwich domain of tissue transglutaminase. J. Biol. Chem., 280:23675-23683.
Zemskov, E., A. Janiak, J. Hang, A. Waghray, and A.M. Belkin. (2006). The role of tissue transglutaminase in cell-matrix interactions. Frontiers in Bioscience, 11:1057-1076.
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