2004 - present: Assistant Professor, Department of Medicine, University of Maryland School of Medicine
2002 - 2004: Research Specialist, Greenebaum Cancer Center, University of Maryland School of Medicine
2001 - 2002: Assistant Professor, Department of Pathology, University of Maryland School of Medicine
1999 - 2001: Principle Investigator, Department of Experimental Pathology, Walter Reed Army Institutes of Research
1998 - 1999: Senior Scientist, Quality Biologic Inc., Gaithersburg, MD
1990 - 1998: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
* 1997 - 1998: Senior Scientist
* 1991 - 1997: Research Associate
* 1990 - 1991: Volunteer, sponsored by international scholarship
1981- 1990: Faculty, Department of Pathology, Beijing Medical University, Beijing, China
1977- 1978: (Residency) Department of Pathology, Beijing Tongren Hospital, Beijing, China
Our laboratory is conducting pre-clinical studies in prostate cancer. During the past seven years, we used SCID mice bearing human LNCaP tumors and TRAMP model to find the optimal method of using chemotherapy and hormone therapy for the treatment of prostate cancer. We are also interested in the molecular mechanisms of the in vivo study result. Molecules that play important roles in apoptosis, angiogenesis, transcription, proliferation, as well as multi drug resistance are investigated at both RNA and protein levels. The study results have been published in Clinical Cancer Research, 2006 and 2008, as well as in Prostate 2009.
Tang, Y., L Wang, O Goloubeva, DongIk Lee, and Arif Hussain. 2009. The relationship of neuroendocrine carcinomas to anti-tumor therapies in TRAMP mice. The Prostate (in press)
Tang, Y., L Wang, O Goloubeva, MA Khan, B Zhang, and A Hussain. 2008. Divergent effects of castration on prostate tumors in TRAMP mice: possible implications for therapy. Clin Cancer Res. 14:2936-43.
Tang, Y., MA Khan, O Goloubeva, DI Lee, D Jelovac, AM Brodie, and A. Hussain. 2006. Docetaxel followed by castration improves outcomes in LNCaP prostate cancer-bearing severe combined immunodeficient mice. Clin Cancer Res. 12:169-174.
O'Neill, J.P., Velalar, C.N., Lee, D.Ik, Zhang, B., Nakanishi, T., Tang, Y. et al. 2006. Thapsigargin resistance in human prostate cancer cells. Cancer, 107:649-59.
Chu WS, Liang Q, Tang Y, King R, Wong K, Gong M, et al. Rotrasond-accelerated tissue fixation/processing achieve superior morphology & macromolecule integrity with storage stability. J Histochem Cytochem. DOI: 10. 1369/JHC.5a6803, 2005. (Online publication)
Tang Y, Geng Z, Goloubeva O, Wang L, Hussain A. Angiogenesis in LNCaP xenografts undergoing hormone ablation. AACR Special Conference: Anti-angiogenesis and drug delivery to tumors: Bench to bedside and back. Boston, MA, 2005.
Tang Y, Khan MA, Hussain A. Evaluation of chemo-hormone therapy in a SCID mouse model of human prostate cancer (Abstract). Special Conference: Basic, Translational, and clinical Advances in Prostate Cancer. Bonita Spring, FL, 2004.
Hussain A, Tang Y, Khan MA, Goloubeva O. Docetaxel (D) followed by castration (C) improves anti-tumor effects in human prostate cancer cell-bearing SCID mice (Abstract). ASCO Annual Meeting, Orlando, Florida, 2005.
Tang Y, Kim WK, Torrey TA, Freed EO, Morse HC, III. Cellular motor protein KIF4 associates with HIV-1 Gag protein. J. of Virology, 73 (12):10508-13, 1999.
Kim WK, Tang Y, Okada Y, Torrey TA, Chattopadhyay SK, Lyu MS, Kozak CA, Pfleiderer M, Falkner FG, Dorner F, Choi WJ, Hirokawa N, Morse HC, III. Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein. J of Virology, 72(8):6898-6901, 1998.
Hugin AW, Tang Y. An immunochemical focus assay to quantify replication competent and defective virus involved in murine acquired immunodeficiency syndrome (MAIDS). J. Virol Meth, 77:217-224, 1999.
Tang Y, Hugin AW, Giese NA, Gabriel L, Chattopadhyay SK, Fredrickson TN, Kagi D, Hartley JW, Morse HC, III. Control of Immunodeficiency and Lymphoproliferation in Morse AIDS: Studies of Mice Deficient in CD8+ T cells or Perforin. Journal of Virology, 71. 3:1808-13, 1997.
Liao XB, Tang Y, Chattopadhyay SK, Hartley JW, Morse HC, III. Upregulation of Gfi-1, a Gene Involved in IL-2-Independent Growth of T Cells, in a Murine Retrovirus-Induced Immunodeficiency Syndrome. In Vivo, 11: 9-12, 1997.