Personal HistoryClinical Training: I graduated from the Shanghai Second Medical University in 1982. I had my residency training in psychiatry and fellowship training in geriatric psychiatry at the Medical College of Virginia, The Virginia Commonwealth University from 1998-2003. I joined, as an attending psychiatrist and assistant professor, the Department of Psychiatry at the University of Maryland in 2003.
Research Training: I obtained a Ph.D. degree in Developmental Neurobiology at the Medical College of Wisconsin in 1993. From 1993 to 1998, I was a postdoctoral fellow in the National Cancer Institute of National Institutes of Health (NIH).
Research Interests1) Mechanisms of gender differences in depressive disorders.
The life time prevalence of major depressive disorders for women is approximately twice that of men. Interestingly, the MDD prevalence in males and females is not significantly different during childhood. Following puberty, however, the MDD prevalence reaches a significant difference between females and males. Evidence suggests that gonadal hormones, both estrogens and androgens, may play important roles in the gender differences in depression. Our major interest is to explore whether perinatal exposure to gonadal hormones affects depression during adulthood.
2) Role of hypogonadism (testosterone deficiency) in elderly men with depressive disorders.
Late-life depression and hypogonadism are both common in older men and appear to be related. Numerous studies suggest that testosterone deficiency is associated with depressive disorders. Some clinical trials suggest that testosterone improves depressive symptoms in hypogonadal men. However, testosterone replacement therapy has not yet emerged into a routine clinical treatment for depressive disorders.
We want to know the prevalence of hypogonadism in elderly men with depressive disorders. Our preliminary studies indicated that hypogonadism is very common in elderly male patients with major depressive disorders, suggesting testosterone deficiency may be an important risk factor for depressive disorders in elderly men. In future studies, we will investigate how different criteria for hypogonadism affect observed prevalence. Ultimately, we hope to characterize a subtype of hypogonadism that is most responsive to antidepressant treatment with testosterone.
Clinical SpecialityAdult and Geriatric Psychiatry
Grants and Contracts:
Title: Mechanisms of hippocampal sex difference and depression.
Agency: BIRCWH Scholar, NIH K-12 BIRCWH IV (Building Interdisciplinary Research Careers in Women's Health)
Status: April 2008-March 2010
The prevalence of major depressive disorders (MDD) in women is as twice as in men. Underling mechanisms remain unresolved. We want to explore whether estrogen-induced gliogenesis and androgen-induced neurogenesis in the hippocampus during neonatal development may play a role in the gender difference in MDD. This study will be conducted in rats.
Zhang, J-M, Konkle, ATM, Zup, SL and McCarthy, MM Impact of sex and hormones on cell proliferation in the developing hippocampus: A novel source of sex dimorphism? In press: European J Neuroscience
Ren, ZG., Porzgen, P., Zhang, J-M., Chen, XR., Amara, SG., Blakely, RD., and Sieber-Blum, M. (2001). Autocrine Regulation of NET Expression. Mol Cell Neurosci. 17, 539-550
Zhang, J-M., Zhao, X-H., Wei, Q., and Paterson, MB. (1999). Direct Inhibition of G1 cdk Kinase Activity by MyoD Promotes Myoblast Cell Cycle Withdrawl and Termination. EMBO J. 18, 6983-6993
Zhang, J-M., Wei, Q., Zhao, X-H., and Paterson, BM. (1999). Cdk-4 Inhibition of Myogenesis through a Direct MyoD-Cdk-4 Interaction in the Absence of Kinase Activity. EMBO J. 18, 926-933
Zhang, J-M., Chen, L., Krause, M., Fire, A., and Paterson, BM. (1999). Evolution Conservation of MyoD Function and Differential Utilization of E-Proteins. Dev. Biol. 208, 465-472
Sieber-Blum, M. and Zhang, J-M. (1998). Multiple Neurotrophin Actions During Early Neural Crest Cell Development: in Neurotrophins and the Neural Crest. (M. Sieber-Blum, ed.), CRC Press
Krause M., Park, M., Zhang, J-M., Yuan, J., Harfe, B., Xu, S-Q., Greenwald, I., Cole, M., Paterson, BM., and Fire, A. (1997). A C. elegan E/Daughterless bHLH Protein Marks Neural but not Atriated Muscle Development. Development 124, 2179-2189
Sieber-Blum, M. and Zhang, J-M. (1997). Growth Factor Action in Neural Crest Cell Diversification. J. Anat. 191, 493-499
Zhang, J-M., Dix, J., Langtimm-Sedlak, C., Trust, T., Schroeder, B., Hoffmann, R., Strosberg, AD., Winslow, JW., and Sieber-Blum, M. (1997). Neurotrophin-3 - and Norepinephrine-medicated Adrenergic Differentiation and the Inhibitory Action of Desipramine and Cocaine. Journal of Neurobiology 32, 262-280
Zhang, J-M. and Sieber-Blum, M. (1997). Mitogenic and Anti-proliferative Signals for Neural Crest Cells and the Neurogenic Action of TGFb-1. Developmental Dynamics 208, 375-386
Zhang, J-M. and Sieber-Blum, M. (1992). Characterization of the norepinephrine Uptake System and the Role of Norepinephrine in the Expression of the Adrenergic Phenotype by Quail Neural Crest Cells in Clonal Culture.