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Yi Ning M.D., Ph.D.

Academic Title: Clinical Associate Professor
Primary Appointment: Pathology
Additional Title(s): Director, Cytogenetics Lab
yning@som.umaryland.edu
Location: MSTF, 717
Phone: 410-706-4063

Personal History:

Education

M.D., Shanghai First Medical College, Shanghai, P.R. China, 1984

Ph.D., Baylor College of Medicine, Houston, TX, 1991

Post Graduate Training

Fellow, Dept. Human Genetics, Baylor College of Medicine, Houston, TX

Fellow, National Human Genome Research Institute, NIH, Bethesda, MD

Research Interests:

Our laboratory offers cytogenetic diagnosis for both constitutional and acquired chromosome abnormalities. Our research has focused on the detection and characterization of subtle chromosome abnormalities in hematological malignancies.

Clinical Speciality:

American Board of Medical Genetics certified Clinical Cytogeneticist

Publications:

Schrock, E., du Manoir, S., Veldman, T., Schoell, B., Wienberg, J., Ferguson-Smith, M.A., Ning, Y., Ledbetter, D.H., Bar-Am, I., Soenksen, D., Garini, Y., and Ried, T.: Multicolor spectral karyotyping of human chromosomes. Science 273:494-497. 1996.

Ning, Y., Roschke, A., Smith, A.C.M., Macha, M., Precht, K., Riethman, H., Ledbetter, D.H. (group 1), Flint, J., Horsley, S., Regan, R., Kearney, L., Knight, S., Kvaloy, K., Brown, W.R.A. (group 2). A complete set of human telomeric probes and their clinical application. Nature Genetics 14:86-89. 1996.

Ning, Y., Laundon, C.H., Schrock, E., Buchanan, P., and Ried, T.: Prenatal diagnosis of a mosaic extra structurally abnormal chromosome by spectral karyotyping. Prenatal Diagnosis 19:480-482. 1999.

Rosenberg, M.J., Vaske, D., Killoran, C.E., Ning, Y., Wargowski, D., Hudgins, L., Tifft, C.J., Meck, J., Blancato, J.K., Rosenbaum, K., Pauli, R.M., Weber, J., and Biesecker, L.G.: Detection of chromosomal aberrations by a whole-genome microsatellite screen. Am J Hum Genet 66:419-427. 2000.

Knight, S.J., Lese, C.M., Precht, K.S., Kuc, J., Ning, Y., Lucas, S., Regan, R., Brenan, M., Nicod, A., Lawrie, N.M., Cardy, D.L., Nguyen, H., Hudson, T.J., Riethman, H.C., Ledbetter, D.H., and Flint, J.: An optimized set of human telomere clones for studying telomere integrity and architecture. Am J Hum Genet 67:320-332. 2000.

Ning, Y., Xu, J.F., Li, Y., Chavez, L., Riethman, H.C., Lansdorp, P.M., and Weng, N.: Telomere length and the expression of natural telomeric genes in human fibroblasts. Hum Mol Genet 12:1329-1336. 2003.

Thomas, L., Stamberg, J., Gojo, I., Ning, Y., and Rapoport, A.P.: Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: two case reports and a review of literature. Am J Hematol 77:55-61. 2004.

Crowley, J.A., Butler, M.S., Ronnenburg, M.J., Ament, C.N., Meekins, J.S., and Ning, Y.: Development of a dual color FISH probe set on chromosome 6q to improve cytogenetic diagnosis of lymphoid malignancies. Cancer Genet Cytogenet 157:78-81. 2005.

Crowley, J.A., Wang, Y., Rapoport, A.P., and Ning, Y.: Detection of MOZ-CBP fusion in acute myeloid leukemia with 8;16 translocation. Leukemia 12:2344-2345. 2005.

Cancer and Leukemia Group B 8461; Farag SS, Archer KJ, Mrozek K, Ruppert AS, Carroll AJ, Vardiman JW, Pettenati MJ, Baer MR, Qumsiyeh MB, Koduru PR, Ning Y, Mayer RJ, Stone RM, Larson RA, Bloomfield CD.: Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood. 108:63-73. 2006.

Reader J.C., Zhao F.X., Butler, M.S., Rapoport, A.P., and Ning, Y.: REL-Positive Double Minute Chromosomes in Follicular Lymphoma. Leukemia 21:842-844. 2007.

Chang H, Qi X, Xu W, Reader JC, Ning Y.: Analysis of 6q deletion in Waldenstrom macroglobulinemia. Eu J Haematol. 79:244-247. 2007

Reader JC, Leng Q, Rassool FV, Ning Y.: Regulation of differentiation by a PHD domain in the NUP98-PHF23 fusion protein. Leuk Res. 34:1094-1097. 2010

Meekins J, Butler M, Skinner M, Shippy R, Greene C, Ning Y.: Microarray analysis of an unbalanced t(4;13) translocation narrows down the trisomy 13 associated polydactyly to a 7 Mb region. Am J Med Genet. 152A:2906-2907. 2010

Yu L, Reader JC, Chen C, Zhao XF, Ha JS, Lee C, York T, Gojo I, Baer MR, Ning Y.: Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. Leukemia. 25:367-371. 2010

Yu L, Slovak ML, Mannoor K, Chen C, Hunger SP, Carroll AJ, Schultz RA, Shaffer LG, Ballif BC, Ning Y.: Microarray detection of multiple recurring submicroscopic chromosomal aberrations in pediatric T-cell acute lymphoblastic leukemia. Leukemia. 25:1042-1046. 2011