SOM Faculty Profile : Wilbur H Chen

Wilbur H Chen

Wilbur H Chen M.D.

Academic Title: Assistant Professor

Primary Appointment: Medicine

wchen@medicine.umaryland.edu

Location: HSF1 480

Phone: (410) 706-5328

Fax: (410) 706-6205

Research Interests

Dr. Chen is a clinical vaccinologist with a primary interest in developing vaccines for the elderly. He has experience in conducting influenza vaccine trials (Seasonal and Avian H5N1 influenza). He also has done basic laboratory research which involves the study of mucosal delivery of an endotoxin-based sepsis vaccine, the role of Toll-like receptors (TLR) in anti-bacterial host defenses and murine models of gram-negative pneumonia.

Publications

Chen WH, Balakonis PA, and Tsai CM. Detection of lipopolysaccharides on nylon membranes. J Endotoxin Res 1995; 2:405-10.

Tsai CM, Chen WH, and Balakonis PA. Neisseria meningitidis lipooligosaccharides mimic glycolipids and glycoproteins in having NeuNAcï¡2-3Galï¢1-4GlcNAc sequence. Glycoconjugate J. 1995; 2:562.

Tsai CM, Chen WH, and Balakonis PA. Characterization of terminal NeuNAcï¡2-3Galï¢1-4GlcNAc sequence in lipooligosaccharides of Neisseria meningitidis. Glycobiology 1998; 8:359-65.

Opal SM, Palardy JE, Chen WH, Parejo NA, Bhattacharjee AK, and Cross AS. Active immunization with a detoxified endotoxin vaccine protects lethal polymicrobial sepsis: Its use with CpG adjuvant and potential mechanisms. J Infect Dis 2005; 192:2074.

Lu W, Hisatsune A, Koga T, Kato K, Kuwahara I, Lillehoj EP, Chen WH, Cross AS, Gendler SJ, Gewirtz AT, Kim KC. Cutting Edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immunology 2006; 176:3890.

Joshi VD, Kalvakolanu DV, Chen WH, Zhang L, Kang TJ, Thomas KE, Vogel SN, and Cross AS. A role for STAT1 in the regulation of lipopolysaccharide-induced interleukin-1-beta expression. J Interferon & Cytokine Res 2006; 26:739-747.

Basu S, Kang TJ, Chen WH, Fenton MJ, Baillie L, Hibbs S, Cross AS. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 2007; 75: 2351.

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