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Mohammad M. Sajadi
 

Mohammad M. Sajadi M.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
Additional Title(s): Assistant Professor, Division of Clinical Care and Reserach, Institute of Human Virology
msajadi@ihv.umaryland.edu
Location: Institute of Human Virology N548
Phone: 410-706-1779
Fax: 410-706-1992
Lab: 410-706-4652
 

Personal History:

Dr. Mohammad Sajadi oversees the NVS cohort, HIV-1 infected patients who control viral replication in the absence of HIV therapy. I have been studying the NVS and other HIV patients with low viral loads as a model to study HIV humoral immunity. I work closely with the Division of Basic Science and Vaccine Research, and oversee a project to directly sequence antibody from patient plasma, as well as studying the common characteristics of antibodies that mediate the neutralization response in HIV infection.


Publications:

  1. Guan Y, Pazgier M, Sajadi MM, Kamin-Lewis R, Al-Darmarki S, Flinko R, Lovo E, Wu X, Robinson JE, Seaman MS, Fouts TR, Gallo RC, DeVico AL, Lewis GK. Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E69-78. PMCID: PMC3538257
  2. Sajadi MM, Pulijala R, Redfield RR, Talwani R. Chronic immune activation and decreased CD4 counts associated with Hepatitis C Infection in HIV-1 Natural Viral Suppressors. AIDS. 2012 Sep 24;26(15):1879-84. PMCID: PMC3772623
  3. Sajadi MM, Lewis GK, Seaman MS, Guan Y, Redfield RR, DeVico AL. Signature biochemical properties of broadly cross-reactive HIV-1 neutralizing antibodies in human plasma. J Virol. 2012 May;86(9):5014-25. PMCID: PMC3347347
  4. Sajadi MM, Guan Y, Devico AL, Seaman MS, Hossain M, Lewis GK, Redfield RR. Correlation between circulating HIV-1 RNA and broad HIV-1 neutralizing antibody activity. J Acquir Immune Defic Syndr. 2011 Jan 28. PMCID: PMC3110998
  5. Sajadi MM, Shakeri N, Talwani R, Redfield, RR. Hepatitis C infection in HIV-1 Natural Viral Suppressors. AIDS. 2010 Jul 17;24(11):1689-95. PMCID: PMC2894991
  6. Y Guan, MM Sajadi, R Kamin-Lewis, T Fouts, A Dimitrov, Z Zhang, R Redfield, AL DeVico, R Gallo, GK Lewis. Humoral Immunity against Conserved Epitopes of the HIV-1 Envelope Protein Archived in Memory B cells in Natural Viral Suppressors: Discordance with Plasma Antibodies. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3952-7. PMID: 19225108
  7. MM Sajadi, NT Constantine, DL Mann, M Charurat, E Dadzan, P Kadlecik, RR Redfield. Epidemiologic Characteristics and Natural History of HIV-1 Natural Viral Suppressors. J Acquir Immune Defic Syndr. 2009 Apr 1;50(4):403-8.
  8. DJ Riedel, MM Sajadi, CL Armstrong, JS Cummings, C Cairo, RR Redfield, CD Pauza. Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells. AIDS. 2009 Jul 15. PMID: 19609200
  9. A Yadav, P Fitzgerald, MM Sajadi, B Gilliam, MK Lafferty, R Redfield, W Reid. Increased expression of Suppressor of Cytokine Signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 Disease. Virology. 2009 Mar 1;385(1):126-33. Epub 2009 Jan 9.PMID: 19135225
  10. MM Sajadi, A Heredia, N Le, N Constantine, R Redfield. HIV-1 Natural Viral Suppressors: Control of Viral Replication in the Absence of Therapy. AIDS. 2007 Feb 19;21(4):517-9.