|
Personal History
Education
- 1971: B.A., Johns Hopkins University, Baltimore, MD
- 1975: Ph.D., (Biology) Yale University, New Haven, CT
- 1978: M.D., Johns Hopkins University School of Medicine
- 1978-1979: Medical Intern, Baltimore City Hospital, and Fellow in Medicine, Johns Hopkins University School of Medicine
- 1979-1982: Resident, Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY
- 1982-1983 Fellow, Department of Neurology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY
Research Interests
Development of new therapeutics for Alzheimer's disease, Parkinson's disease, ALS and related neurodegenerative diseases and movement disorders. Basic research area of interest is the development of vectors to deliver macromolecular therapies to the brain. Current research interests include designer neurotoxins, novel neuroprotectants against excitotoxicity and neuronal differentiation of stem cells
Clinical Speciality
Alzheimer's Disease and Dementias. Parkinson's Disease and Movement Disorders, Surgical treatment of Movement Disorders, Botulinum neurotoxin treatment of motor disorders
Lab Techniques and Equipment
Cell and tissue culture, protein expression and characterization, confocal microscopy, muscle physiolgy and small-animal surgery
Publications
Selected Publications
Francis JW, Bastia E, Matthews CC, Parks DA, Schwarzschild MA, Brown RH Jr, Fishman PS. Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS. Brain Research 1011:7-13, 2004.
Fishman PS. Clinical uses of botulinum toxin. Adv Stud Med 5:176-184,2005.
Benn SC, Ay I, Bastia E, Celia SA, Pepinsky RB, Fishman PS, Brown RH Jr, Francis JW. Tetanus toxin fragment C fusion facilitates delivery to CNS neurons from the cerebrospinal fluid in mice. J Neurochem 95:1118-31, 2005.
Jafri MS, Farhang S, Tang R, Desai N, Fishman PS, Rohwer RG, Tang C-T. Optical coherence tomography in the diagnosis and treatment of neurological disorders. 10: 510-521, 2005
Fishman PS, Matthews CC, Parks DA, Box M, Fairweather NF. Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin. J Neurosci Res. 2006 Jun 1;83(8):1540-3.
Larsen KE, Benn SC,Ay I,Chian R-J, Celia SA, Remington MP, Bejarano M, Liu M, Ross J,Carmillo P, Sah D, Phillips KA, Sulzer D, Fishman PS, Pepinsky B, Brown RH Jr., Francis JW, A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice. Brain Research 2006 Nov 20;1120(1):1-12
Messmer K, Remington MP, Skidmore F, Fishman PS. Induction of tyrosine hydroxylase expression by the transcription factor Pitx3.International Journal of Developmental Neuroscience 2007 Feb;25(1):29-37.
Matthews CC Zielke HR, Fishman PS, Remington MP, Bowen TG. Glutamate decarboxylaseprotects neurons from excitotoxic injury. J Neuroscience Research 2007 Mar;85(4):855-9.
Fishman PS. Paradoxical aspects of Parkinsonian tremor. Movement Disorders (in press)