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Michael E. Kleinberg

Michael E. Kleinberg M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Medicine
Additional Title(s): Director, Infectious Diseases Cancer Center Program, University of Maryland Greenebaum Cancer Center
Location: UMMC, Room N9E05
Phone: 410-328-2679
Fax: (410) 328-6896
Cell: (410) 328-2337 x9936

Personal History:

My clinical interests are the infectious complications of patients with cancer treated in the University of Maryland Greenebaum Cancer Center. Cancer patients may be treated with chemotherapy, immune modulators or bone marrow/stem cell transplantation. The host immune system is impaired to varying degrees depending on the type of malignancy and the way in which it is treated. The most profoundly immunosuppressed cancer patients are frequently infected, often by pathogens that are not virulent to people defended by normal immune systems.

My academic interests are development of methods to optimize treatment of infections in complicated neutropenic patients and in bone marrow/stem cell transplant recipients. The complexity of infection management in these patients defies standard drug/bug models since patients must often be treated empirically for some time before it is possible to make accurate diagnoses. These patients are best treated through algorithm-driven treatment models where treatment choices are reevaluated repeatedly as diagnostic testing data and observations of patients responses are used to refine the initial approaches and to arrive at the best outcomes.

I have a strong interest in quality improvement initiatives in my roles as Director of the University of Maryland Medical Center Antimicrobial Stewardship Program and as chair of the University of Maryland Greenebaum Cancer Center Data Safety Monitoring (DSM) Committee. The goal of antimicrobial stewardship is to optimize diagnosis and treatment of infections in UMMC patients by promoting and monitoring clinical best practices. The goal of the DSM committee is to maximize safety of patients enrolled in clinical trials offered by the Cancer Center.

Research Interests:

  1. Diagnosis, treatment, and prevention of infections in patients with hematological malignancies and in patients receiving bone marrow/stem cell transplants
  2. Improving outcomes in patients with a spectrum of infections though antimicrobial stewardship initiatives

Clinical Specialty:

  1. Management of infectious diseases in oncology patients
  2. Antimicrobial stewardship


  1. Kleinberg, M. 2005. Aspergillosis in the CLEAR Outcomes Trial: Working Toward a Real-World Clinical Perspective. Medical Mycology 43:S289-S294.
  2. Johnson, M.D., Kleinberg, M., Danziger, L., and Ostrosky-Zeichner, L. 2005. Pharmacoeconomics of Antifungal Pharmacotherapy - Challenges and Future Directions. Expert Opin. Pharmacother. 6:2617-2632.
  3. Thom, K.A., Kleinberg, M., Roghmann, M.C. 2013. Infection Prevention in the Cancer Center. Clin. Infect. Dis. 57:579-85.
  4. Hess, A.S., Kleinberg, M., Sorkin, J.D., Netzer, G., Johnson, J.K., Shardell, M., Thom, K.A., Harris, A.D., Roghmann, MC. 2014. Prior Colonization is Associated with Increased Risk of Antibiotic-resistant Gram-negative Bacteremia in Cancer Patients. Diag. Micro. Infect. Dis. 79(1):73-76.
  5. Taremi, M., Kleinberg, M.E., Wang, E.W., Gilliam, B.L., Ryscavage, P.A. 2015. Galactomannan Antigen Detection Using Bronchial Wash and Broncoalveolar Lavage in Patients with Hematologic Malignancies. Ann. Clin. Microbiol. Antimicrob. 14:50-2.