SOM Faculty Profile : Myron M Levine

Myron M Levine

Myron M Levine M.D., D.T.P.H.

Academic Title: Professor

Primary Appointment: Medicine

Secondary Appointments: Epidemiology and Preventive Medicine, Microbiology and Immunology, Pediatrics

Administrative Title: Division Head, Geographic Medicine

Additional Title(s): Simon and Bessie Grollman Distinguised Professorship

MLevine@medicine.umaryland.edu

Location: HSF 1, Room 480

Phone: (410) 706-7588

Fax: (410) 706-6205

Personal History

Dr. Levine has been Director of the Center for Vaccine Development since its inception, and has created therein an environment that is unusually rich in intellectual ferment and stimulation. He is one of the most vocal advocates of mucosal immunization, i.e., the administration of vaccines by oral and intranasal routes to avoid the unpleasantness and occasional dangers of parenteral injections.

Research Interests

Dr. Levine has made substantial contributions in basic vaccinology and clinical research. In recent years, his basic laboratory research has focused on the use of attenuated Salmonella typhi as live oral typhoid vaccines and as live vector vaccines that express the protective antigens of unrelated pathogens and deliver them to the human immune system. His clinical research has involved studies of pathogenesis and the assessment of a variety of vaccines in adults and children in Baltimore, as well as in many developing countries. He has been a pioneer in carrying out clinical trials in developing countries, including studies of vaccines developed at our center. He designed, arranged and supervised the performance of several large-scale, randomized, controlled field trials investigating the efficacy of live oral typhoid vaccines (which led to licensure of Ty21a by the FDA) and a vaccine to prevent invasive disease caused by Haemophilus influenzae type b. Dr. Levine is the senior editor of New Generation Vaccines and has published over 400 peer reviewed journal articles. He was elected to the Institute of Medicine of the National Academy of Science, the Association of American Physicians, the American Society of Clinical Investigation and the Interurban Clinical Club. He is the recipient of the Albert B. Sabin Gold Medal Award for lifetime achievement in the area of vaccine development and implementation.

Publications

Tapia, MD, Sow SO, Medina-Moreno S, Pasetti M, Kotloff KL, Levine MM. A serosurvey to identify the “window of vulnerability” to wild type measles among infants in rural Mali. Am J Trop Med Hyg, 73:26-31, 2005.

Sow SO, Diallo S, Campbell JD, Tapia M, Keita T, Keita MM, Murray P, Kotloff KL, Levine MM. Burden of Invasive disease caused by Haemophilus influenzae type b in Bamako, Mali: impetus for routine infant immunization with conjugate vaccine. Pediatr Infect Dis J, 24:533-7, 2005.

Vallès F-X, Flannery B, Roca A, Mandomando I, Sigauque B, Sanz S, Levine MM, Schuchat A, Soriano-Gabarro M, Alonso P. Serotype distribution and antibiotic susceptibility of invasive and nasopharyngeal isolates of Streptococcus pneumoniae among children in rural Mozambique. Pediatr Infect Dis J, in press.

Lagos R, Hoffenbach, Scemama, Dupuy, Schodel F, Hessel L, and Levine MM. Lot-to-lot consistency of a combined hexavalent diphtheria-tetanus-acellular-pertussis, hepatitis B, inactivated polio and Haemophilus B conjugate vaccine to healthy Chilean infants at 2, 4 and 6 months of age. Human Vaccines, 1:112-117, 2005.

Vidal MO, Kruger E, Durán C, Lagos R, Levine M, Prado V, Toro C, Vidal RA. A single multiplex PCR assay to identify simultaneously the six categories of diarrheagenic Escherichia coli associated to enteric infections. J Clin Micro, 43:5362-5365, 2005.

Song MK, Vindurampulle CJ, Capozzo AVE, Ulmer J, Polo JM, Pasetti MF, Barry EM, Levine MM. Characterization of immune responses induced by intramuscular vaccination with DNA vaccines encoding measles virus hemagglutinin and/or fusion proteins. J of Virology 79:9854-9861, 2005.

Barry EM, Wang J, Wu T, Davis T, Levine MM. Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model. Vaccine, in Press, 2005. Available on line.

Fulla N, Prado V, Duran C, Lagos R, Levine MM. Surveillance for antimicrobial resistance profiles among Shigella species isolated from a semirural community in the northern administrative area of Santiago, Chile. Am J Trop Med Hyg 72:851-4, 2005.

Levine MM, Lepage P. Prevention of typhoid fever. Adv Exp Med Biol, 568:161-73, 2005

Levine MM, Gallo RC. A Tribute to Maurice Ralph Hilleman. Human Vaccines, 1:93-130, 2005.

Links of Interest

Center for Vaccine Development

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