SOM Faculty Profile : Hegang Chen

Hegang Chen Ph.D.

Academic Title: Associate Professor

Primary Appointment: Epidemiology and Preventive Medicine

hchen@epi.umaryland.edu

Location: HH, 113

Phone: (410) 706-4067

Fax: (410) 706-3808

Personal History

Education

M.S., Mathematics, University of Mississippi

Ph.D., Statistics, University of Illinois

Professional Background

1993 – 1997: Assistant Professor/Senior Instructor, Case Western Reserve University, School of Medicine, Department of Epidemiology and Biostatistics

1997 – 1999: Assistant Professor, Virginia Polytechnic Institute and State University, Department of Statistics

1999 – 2002: Assistant Professor, University of Minnesota, School of Public Health, Division of Biostatistics

1999 – 2002: Member, University of Minnesota Cancer Center

2000 – 2002: Member, University of Minnesota Biomedical Genomics Center

2002 – present: Associate Professor/Assistant Professor, University of Maryland School of Medicine, Department of Epidemiology and Preventive Medicine

2002 – present: Member, University of Maryland General Clinical Research Center Advisory Committee

2006 – present: Member, Program in Genetics and Genomic Medicine, University of Maryland School of Medicine

Research Interests

Dr. Chen has extensive collaborative research experience in the design, conduct and analysis of clinical trials, laboratory investigations and epidemiological research. In addition to serving as a statistician for the General Clinical Research Center at University of Maryland and VA Maryland Health Care Center, he is co-investigator on many NIH funded grants such as "Prevention of Neonatal Infection in the Indian Community Setting Using Probiotics", "Pharmacogenomics of Thiazolidinediome Response" and "Age and Sex Effects on Nerve Agent Damage to the Brain and Antidotal Therapies". One of Dr. Chen's major research interests is application of statistical methods in molecular biology. By using molecular technology, mass spectrometry and microarray technology, he currently works with many translational researchers on NIH-funded projects to study molecular mechanisms of hormone-independent growth and metastasis of prostate cancer, gene expression signatures of early cardiac remodeling, and biological basis for the racial disparity in HCV treatment outcomes. In addition to biomedical collaborations, Dr. Chen has been developing statistical methodologies relating to the optimal design and analysis of experiments, generalized mixed linear models, and the application of statistical methods in molecular biology. By blending coding theory and finite geometry techniques, he initiates complementary design theory to identify optimal fractional factorial designs. Such designs are widely used in many scientific investigations. Meanwhile he also has studied experimental design for comparative bioavailability studies and its application in pharmacokinetics drug-drug interaction studies, estimation of random effects in generalized linear mixed models and its application in small area estimation for survey data. The design and analysis of microarray experiments is another research focus of his. Dr. Chen is a regular reviewer for the NSF statistics program, Annals of Statistics, Biometrics, Biometrika, Journal of the American Statistical Association, and Journal of the Royal Statistical Society Series B.

Publications

Selected Publications

Chen, H. and Cheng, C-S. (2009) Some Results on 2n-m Designs of Resolution IV with (Weak) Minimum Aberration. Annals of Statistics, in press.

Xu, K., Shimelis, H., Linn, D.E., Jiang, R., Yang, X., Sun, F., Guo, Z., Chen, H., Li, W., Chen, H., Kong, X., Melamed, J., Fang, S., Xiao, Z., Veenstra, T.D. and Qiu, Y. (2009) Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6. Cancer Cell, Vol. 15, 270-282.

Barrows, B.R., Azimzadeh, A.A., McCulle, S.L., Vives-Rodriguez, G., Stark Jr., W.N., Ambulos, N., Yin, J., Chen, H., Balke, C.W., Moravec, C.S., Pierson III, R.N., Gottlieb, S.S., Bond, M. and Johnson, F. L. (2007) Robust Gene Expression Analysis Using Amplified RNA from Biopsy-sized Human Heart Tissue. Journal of Molecular and Cellular Cardiology, Vol. 42, 260-264.

Tripathy, R., Parida, S., Das, L., Mishra, D.P., Tripathy, D., Das, M.C., Chen, H., Maguire, J. and Panigrahi, P. (2007) Clinical Manifestations and Predictions of Severe Malaria in a Low-endemic Setting. Pediatrics, Vol. 120, 454-460.

Chen, H. and Cheng, C-S. (2006) Doubling and Projection: A Method of Constructing Two-Level Designs of Resolution IV. Annals of Statistics, Vol. 34, 546-558.

Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V.D., Njar, V.C., Brodie, A.M., Yu, L., Veenstra, T.D., Chen, H. and Qiu, Y. (2006) Regulation of the Androgen Receptor Activity by Tyrosine Phosphorylation, Cancer Cell, Vol. 10, 309-319.

Rus, V., Chen, H., Zernetkina, V., Magder, L. S., Mathai, S., Hochberg, M. and Via, C. S. (2004) Gene Expression Profiling in Peripheral Blood Mononuclear Cells from Lupus Patients with Active and Inactive Disease, Clinical Immunology, Vol. 112, 231-234.

Chen, H. and Cheng, C-S. (2004) Aberration, Estimation Capacity and Estimation Index. Statistica Sinica, Vol. 14, 203-215.

Hudson, M., Mertens, A., Yasui, Y., Hobbie, W., Chen, H, Gurney, J., Yeazel, M., Recklitis, C.J., Marina, N., Robison, L. and Oeffinger, K. (2003) Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Journal of the American Medical Association, Vol. 290, No. 12 1583-1592.

Chen, R., Xiong, X., Guan, J-L., Kung, H-J., Chen, H. and Y. Qiu (2001) Regulation of a PH-domain-containing Tyrosine Kinase Etk by Focal Adhesion Kinase Through the FERM Domain, Nature Cell Biology, Vol. 3, 439-444.

Wagenaar, A. C., Denk, C. E., Hannan, P., Chen, H. and Harwood, E. M. (2001) Legal Liability of Commercial and Social Hosts for Alcohol-Related Injuries: A National Survey of Accountability Norms and Judgments. Public Opinion Quarterly, Vol. 65, 3, 344-368.

Jiang, J., Jia, H. and Chen, H. (2001) Maximum Posterior Estimation of Random Effects in Generalized Linear Mixed Models, Statistica Sinica, Vol. 11, 97-120.

Chen, H. and Cheng, C-S. (2000) Uniqueness of Some Resolution IV Two-Level Regular Fractional Factorial Designs, SIAM Journal on Discrete Mathematics, Vol. 13, 571-575.

Chen, H. and Cheng, C-S. (1999) Theory of Optimal Blocking of 2n-m Designs, Annals of Statistics, Vol. 27, 1948-1973.

Solodkey, C., Chen, H., Jones, P. K., Katcher, W. and Neuhauser, D. (1998) Patients as Partners in Clinical Research: A Proposal for Applying Quality Improvement Methods to Patient Care, Medical Care, Vol. 36, No. 8, suppl., 13-20.

Chen, H. and Hedayat, A.S. (1998) 2n-m with Resolution III or IV Containing Clear Two-Factor Interactions, Journal of Statistical Planning and Inference, 75,147-158.

Cooper, G. S., Yuan, Z., Bowlin, S. J., Dennis, L., Kelly, R., Chen, H. and Rimm, A. A. (1998) A National Study of the Effectiveness of Mammography in Reducing Breast Cancer Mortality, American Journal of Public Health, Vol. 88, 281-284.

Chen, H., Suen, C-Y. and Wu, C. F. J. (1997) Some Identities on qn-m Designs with Application to Minimum Aberration Designs, Annals of Statistics, Vol. 25, 1176-1188.

Chen, H. and Hedayat, A.S. (1996) 2n-l Designs with Weak Minimum Aberration, Annals of Statistics, Vol. 24, 2536-2548.

Chen, H. and Hedayat, A.S. (1994) Optimum Experimental Design For Comparative Bioavailability Study, Journal of Statistical Planning and Inference, Vol. 42, 271-289.

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