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William F. Regine
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William F. Regine M.D., FACR, FACRO

Academic Title: Professor
Primary Appointment: Radiation Oncology
Secondary Appointments: Diagnostic Radiology and Nuclear Medicine
Administrative Title: Chair, Department Of Radiation Oncology
Additional Title(s): Isadore & Fannie Schneider Foxman Chair in the Department of Radiation Oncology; Executive Director, Maryland Proton Treatment Center (MPTC)
Location: UMMC/Gudelsky, GGK-0101
Phone: (410) 328-2326
Fax: (410) 328-6911

Personal History:

William F. Regine, M.D. is the Isadore and Fannie Schneider Foxman Chairman and Professor of Radiation Oncology at the University of Maryland, ranked top 5 in the country in published NIH rankings for research funding profile. Dr. Regine obtained his training at Thomas Jefferson University Hospital in Philadelphia where he also completed a Radiation Oncology Fellowship in Gastrointestinal and Head and Neck malignancies. Dr. Regine is considered a National and International expert in the area of GI and CNS malignancies, as well as in the use of Stereotactic Radiosurgery (SRS). His first faculty appointment was at St. Jude’s Children’s Cancer Research Hospital where as a Clinical Investigator he helped redefine new standards of care in children with rhabdomyosarcomas and in developing a pediatric SRS program. After 2 years at St. Jude he dedicated his career to clinical research in adult cancer patients. He has since served as Principal Investigator or Co-Principal Investigator in at least 4 national NCI sponsored cooperative group clinical trials (Radiation Therapy Oncology Group [RTOG] protocol 97-04,RTOG Protocol BR-0018, RTOG Protocol BR-0013, RTOG Protocol 08-48). He is a member of the GI and CNS Tumor steering committees for the RTOG and is the Chairman of the GI section of the National Oral Board examination for trainees in Radiation Oncology.

Dr. Regine served as the Principal Investigator of RTOG 9704 study evaluating adjuvant therapy in patients with pancreatic cancer published in the Journal of the American Medical Association in 2008 and the Annals of Surgical Oncology 2011(Regine). This study defined a new standard of care for patients with pancreatic cancer. He has also been the Radiation Oncology Principal Investigator/Study Chairman for 2 Institutional clinical trials published in JAMA (Patchell) and the Lancet (Patchell) which defined new standards of care for patients with brain metastases and malignant spinal cord compression. He is co-Editor of “Principles and Practices of Stereotactic Radiosurgery”, the first comprehensive textbook of its kind. More recently, Dr. Regine published the benefits of advanced imaging and treatment delivery (Yovino-2012) techniques in pancreatic cancer which are the basis for the current accruing RTOG Protocol 0848 for which Dr. Regine is a Study Chairman. Dr. Regine is also co-inventor of the first of its kind treatment device completely dedicated to the stereotactic radiation treatment of early stage breast cancer known as the GammaPod.

Research Interests:

Dr. Regine's research interests include the study and treatment of pancreas/gastrointestinal cancers, brain metastases/ tumors and head and neck cancers. He is also Nationally recognized for his expertise in Stereotactic Radiosurgery (SRS).

Clinical Specialty:

Gastrointestinal Malignancies, Pancreatic cancer, Central Nervous System malignancies, Brain metastases, Head and Neck cancers, Stereotactic Body Radiation Therapy (SBRT), Stereotactic Radiosurgery (SBRT), Gamma Knife Radiosurgery and Proton Therapy.

Current Investigational Studies:

A Phase III Postoperative Adjuvant Therapy with Gemcitabine vs. Gemcitabine and Irradiation Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma Resected with Curative Intent. RTOG Protocol #0848 [Study Co-Chairman]


Books and Chapters

Patchell RA, Regine WF. Whole Brain Radiation Therapy for Brain Metastases. In: Chin LC, Regine WF, eds. Principles & Practice of Stereotactic Radiosurgery. Springer Publishing 2008; 201-206.

Chin LS, Regine WF. Editors. Principles and Practice of Stereotactic Radiosurgery. Springer Publishing, April, 2008.

Pandya N, Garofalo MC, Regine WF. The Case for Adjuvant Chemoradiation Therapy for Pancreatic Cancer. In: Handbook of Pancreatic Cancer. Abbruzzese J, Buchler M, Neoptolemos J, Urrutia R, eds(In Press).

Garofalo MC, Regine WF. Adjuvant Chemoradiation for Pancreatic Cancer: Past, Present, and Future. In: M.D. Anderson Solid Tumor Oncology Series. Pancreatic Cancer. Lowy, Leach, Philip, eds. 2008; 535-548.

Cohen AM, Garofalo MC, DeSimone PA, Hanna NN, Regine WF. Cancer of the Rectum. In: Clinical Oncology 4th Edition. Abeloff M, Armitage JO, Neiderhuber JE, Kastan MB, McKenna WG, eds. Churchill Livingstone, 2008; 1535-1556.

Kwok Y, Patchell RA, Regine WF. Management of Overt Central Nervous System Metastases: Brain and Spinal Cord. In: Principles and Practice of Lung Cancer, Fourth Edition. Pass, HI, Carbone DP, Johnson DH, Minna JD, Scagliotti GV, Turris III AT, eds. Lippincott Williams & Wilkins, 2010; 911-926.

Kwok Y, Patchell, Regine WF. Palliation of Brain and Spinal Cord Metastases. In:  Perez and Brady’s Principles and Practice of Radiation Oncology, Sixth Edition. Edward C. Halperin, MD, David E. Wazer, MD, Carlos A. Perez, MD, and Luther W. Brady, MD. eds. Lippincott Williams & Wilkins, 2013; 1766-1777.

Yovino S, Kwok Y, Regine WF.  Brain and Cranial Nerves. In: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. (Springer-Verlag, 2014).

Chin LS, Regine WF. Editors. Principles and Practice of Stereotacic Radiosurgery, Second Edition, Springer Publishing, 2015

Selected Recent Journal Articles

Yovino S, Poppe M, Jabbour S, David V, Garofalo M, Pandya N, Alexander R, Hanna N, Regine WF. Intensity-Modulated Radiation Therapy Significantly Improves Acute Gastrointestinal Toxicity in Pancreatic and Ampullary Cancers. IJROBP, 79(1): 158-162, January, 2011.

Regine WF, Winter K, Abrams R, Safran H, Hoffman JP, Konski A, Benson Al B, Macdonald JS, RichTA, Willett CG. Fluorouracil Based Chemoradiation with Either Gemcitabine or Flourouracil Chemotherapy Following Resection of Pancreatic Adenocarcinoma: 5-Year Analysis of the US Intergroup/RTOG 9704 Phase III Trial. Ann Surg Oncol 18: 1319-1326, April 2011.

Abrams RA, Regine WF. Failure to Adhere to Protocol Specified Radiation Therapy Guidelines Was Associated with Decreased Survival in RTOG 9704 – A Phase III Trial of AdjuvantChemotherapy and Chemoradiotherapy for Patients with Resected Adenocarcinoma of the Pancreas. Int. J. Radiation Oncology Biol.Phys., 82:809-816, 2012.

Neuner G, Mohiuddin MM, Vander Walde N, Goloubeva O, Ha J, Yu CX, Regine WF. High-Dose Spatially Fractionated Grid Radiation Therapy (SFGRT): A Comparison of Treatment Outcomes with Cerrobend vs. MLC SFGRT. Int. J. Radiation Oncology Biol.Phys., 82:(5)1642-49, 2012.

Strongin A, Yovino S, Taylor R, Wolf J, Cullen K, Ord R, Zimrin A, Strome S, Regine WF, Suntharalingam, M. Tumor Volume Predicts Tumor Control and Survival among Patients with Locally Advanced Head and Neck Cancer Undergoing Definitive Chemoradiation Therapy. Int. J. Radiation Oncology Biol.Phys., 82:(5)1823-30, 2012.

Goodman KA, Regine WF, Dawson L, Ben-Josef E, Haustermans K, Bosch WR, Turian J, Abrams RA. RTOG Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer. Int. J. Radiation Oncology Biol.Phys., 83:(3)901-908, 2012.

Gaugler JE, Eppinger A, King J, Sandberg T, Regine WF. Coping and its Effects in Care Giving. Supportive Care in Cancer. 21:385-395, 2013.

Yu CX, Shao X, Zhang, Regine WF, J, Zheng M, Deng J, Duan Z. GammaPod – A New Device Dedicated For Stereotactic Radiotherapy of Breast Cancer. Med. Phys 40 (5), May, 2013

Chuong M, Boggs D, Patel K, Regine WF, Adjuvant chemoradiation for pancreatic cancer: what does the evidence tell us? Journal of Gastrointestinal Oncology, Vol 5, No. 3, June 2014

Mehta M, Langen K, Regine WF, Expanding the Horizons Of Proton Beam Therapy. Invited editorial. The Cancer Letter, Issue 31 – August 1, 2014