Dr. Wang is a cancer biologist with a special interest in the molecular biology and genetics of human liver cancer. He holds a Bachelor's degree from Shanghai Medical University, a Master's degree from the Chinese Academia of Science and a Ph.D. degree from New York University. He completed postdoctoral fellowships at the Roche Institute of Molecular Biology (1991-1992) and at NCI (1992-1995) with studies on molecular carcinogenesis and signal transduction. Currently, he serves as a Senior Investigator and the Head of the Liver Carcinogenesis Section in the Laboratory of Human Carcinogenesis, NCI, and as an Adjunct Professor at the University of Maryland School of Medicine. He has published over 90 manuscripts and book chapters, and has been frequently invited to give lectures both nationally and internationally. He also provides numerous editorial services and grant reviews.
Cancer genetics and genomics; gene expression profiling; cancer stem cells; hepatocellular cancer
Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J.-M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. and Harris, C. C. (1995) p53 modulation of TFIIH associated nucleotide excision repair activity. Nat Genetics 10: 188-195.
Wang, X. W., Vermulen, W., Coursen, J. D., Gibson, M. J., Lupold, S. E., Forrester, K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. and Harris, C. C. (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev 10: 1219-1232.
Wang, X. W., Coursen, J. D., Zhan, Q., Fornace, A. J., Jr and Harris, C. C. (1999) GADD45 induction of a G2-M cell cycle checkpoint. Proc Natl Acad Sci USA 96: 3706-3711.
Wang, X.W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A.I., Seker, H., Yang, Q., Hu, P., Beresten, S., Bemmels, N.A., Garfield, S. and Harris, C. C. (2001) Functional interaction of p53 and BLM DNA helicase in apoptosis. J Biol Chem 276: 32948-32955.
Ye, Q.H., Qin, L.X., Forgues, M., He, P, Kim, J.W., Peng, A.C., Simon, R., Li, Y., Robles, A.I., Chen, Y., Ma, Z.C, Wu, Z.Q, Ye, S.L., Liu, Y.K., Tang, Z.Y. and Wang, X.W. (2003) Predicting Hepatitis B Virus-Positive Metastatic Hepatocellular Carcinomas Using Gene Expression Profiling and Supervised Machine Learning. Nat Med 9, 416-423.
Forgues, M., Difilippantonio, M.J., Linke, S.P., Ried, T., Nagashima, K., Feden, J., Valerie, K., Fukasawa, K., Wang, X.W. (2003) Involvement of Crm1 in HBx-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol 23, 5282-5292.
Kim, J.W., Ye, Q.H., Forgues, M., Chen, Y., Budhu, A., Sime, J., Hofseth, L.J., Kaul, R. and Wang, X.W. (2004) Cancer-associated molecular signatures in the cirrhotic tissue samples of patients with chronic liver disease. Hepatology 39, 518-27.
Wang, W., Budhu, A., Forgues, M., and Wang, X.W. (2005) Temporal and spatial control of nucleophosmin by the Ran/Crm1 complex in centrosome duplication. Nat Cell Biol 7, 823-30.
Budhu, A., Forgues, M., Ye, Q.H., Jia, H.L., He, P., Zanetti, K.A., Kammula, U.S., Chen, Y., Qin, L.X., Tang, Z.Y., and Wang, X.W (2006). Prediction of metastatic potential and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10, 99-111.
Jia, H.L., Ye, Q.H., Qin, L.X., Budhu, A., Forgues, M., Chen, Y., Liu, X.K., Sun, H.C., Wang, L., Tang, Z.Y. and Wang, X.W. Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma Including Those with Normal Serum Alpha-Fetoprotein and Small Tumors. (2007) Clin Cancer Res, 13, 1133-9, 2007.
Takafuji, V.A., Forgues, M., Unsworth, E., Goldsmith, P., Wang, X.W. A 5-kD osteopontin segment cleaved by matrix metalloproteinase-9 activity is essential for tumor cell invasion in hepatocellular carcinoma. Oncogene, Epub ahead of print, 2007.
Seike, M., Yanaihara, N., Bowman, E.D., Zanetti, K.A., Mechanic, L.E., Budhu, A., Kumamoto, K., Yokota, J., Gemma, A., Kudoh, S., Wang, X.W., Harris, C.C. (2007) A cytokine gene signature of the lung environment predicts lymph node metastasis and prognosis of lung adenocarcinoma. J Nat Cancer Inst, 99, 1-13.