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Research Interests
T-lymphocyte mediated allergic skin diseases, antigen presentation by resident epidermal cells such as Langerhans cells and keratinocytes to skin homing lymphocytes, and immunopharmacology
Publications
Fishelevich R, Malanina A, Luzina I, Atamas S, Smyth MJ, Porcelli SA, Gaspari AA. Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression During Terminal Differentiation. J. Immunol. (submitted, 2005) Niculescu F, Niculescu T, Nguyen P, Puliaev R , Papadimitriou JC, Gaspari AA Rus H and Via CS. Both Apoptosis and Deposition of Complement Membrane Attack Complex are Major Features of Acute Graft-versus Host Disease in the Parent-into-F1 Model. Exp. and Molecular Pathol. (in press 2005)
Roychowdhury S, Vyas PM, Reilly TP, Gaspari AA, Svensson CK Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes . J. Pharmacol. Exp. Therapeutics 314 (1): 43-52, 2005
Burns R, Luzina I, Nasir A, Haidaris CG, Barth RK, Gaspari AA. Keratinocyte-Derived, CD80-Mediated Co-stimulation is Associated with the Development of Hapten-Specific IgE During Contact Hypersensitivity to Th1-dominant haptens. J All. Clin. Imunol. 115(2): 383-90, 2005
Wakem P, Ramirez F, Zlotnick D, Gaspari AA. Heterogeneity of Human Keratinocyte Responses to Allergens and Irritants in an In vitro Assay for CD80 Transcription. J. Appl. Toxicol. 24:485-92, 2004
Cummins DL, Gaspari AA. Photoprotection by Thalidomide in Patients with Chronic Cutaneous Lupus Erythematosus: Discordant Effects on Minimal Erythema Dose and Sunburn Cell Formation. Br.J. Derm. 151(2):458-64, 2004
Lu KQ, Brenneman S, Burns R., Jr., Vink A, Gaines E, Haake A, Gaspari AA. Thalidomide Inhibits Inhibits UVB-Induced Mouse Keratinocytes Apoptosis by a TNF-a Dependent Pathway. Photoderm. Photoimmunol. Photomed. 19: 272-80, 2003
Gaspari AA. Topical Immune Response Modifiers: Mechanism of Action and Clinical Implications. Internal Medicine World Report 18(6): 2-10; 2003
Gaspari AA, Burns RP, Jr., Ferbel B, Tanck C, Bedi GS, Perrella FW. Bacterial Protease Treatment of Natural Rubber Latex Alters its Primary Immunogenicity in a Mouse Model of Sensitization. Clin. Immunol. 105(1): 9-16, 2002
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