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Kai Y Xu
 

Kai Y Xu Ph.D.

Academic Title: Associate Professor
Primary Appointment: Surgery
kxu002@umaryland.edu
Location: MSTF, 434E
Phone: (410) 706-2598
Phone: (410) 706-4299
Fax: (410) 706-0311

Personal History:

Education

B.S.: Henan University, China
M.S.: University of California, San Diego
Ph.D.: University of California, San Diego

Post Graduate Education

1988-1990: Postdoctoral Researcher, Department of Surgery, Harvard University School of Medicine and Department of Neurosurgery, Massachusetts General Hospital
1990-1992: Postdoctoral Associate, Department of Cell Biology and Department of Cellular and Molecular Physiology, Yale University School of Medicine

Employment History

1992-1995: Instructor, Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine
1995-2003: Assistant Professor, Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine
2003-2007: Associate Professor, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine
2007-Present: Associate Professor, Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine

Research Interests:

Na/K-ATPase in molecular medicine, inotropic antibody, heart failure, kidney failure

Publications:

Kyte J, Xu KY, Bayer R. Demonstration that Lysine 501 of the a-Polypeptide of Native Sodium and Potassium Ion Activated Adenosine Phatase is Located on Its Cytoplasmic Surface. Biochemistry (1987)26:8350-8360.

Xu KY, Kyte J. Nucleophilic Behavior of Lysine 501 of the a-Polypeptide of Sodium and Potassium Ion Activated Adenosinetriphosphatase Consistent with a Role in Binding Adenosine Triphosphate. Biochemistry (1989)28:3009-3017.

Xu KY. Any of Several Lysines Can React with 5’-Isothiocyanatofluorescein to Inactivate Sodium and Potassium Ion Activated Adenosinetriphosphatase. Biochemistry (1989)28:5764-5772.

Xu KY. Acid Dissociation Constant and Apparent Nucleophilicity of Lysine 501 of Alpha Polypeptide of Sodium and Potassium Ion Activated Adenosinetriphosphatase. Biochemistry (1989)28:6894-6899.

Canfield VA, Xu KY, D’Aquila T, Shyjan AW, Levenson R. Cloning and Characterization of a Ouabain Resistant Na,K-ATPase from Hydra Vulgaris, Evolution of the Alpha Subunit. New Biologist (1992)4:339-348.

Xu KY. Inhibition of H-transporting ATPase, Ca-transporting ATPase and H/K-transporting ATPase by Strophanthidin. Biochim. Biophys. Acta (1992)1159:109-112.

Xu KY, Zweier JL, Becker LC. Functional Coupling Between Glycolysis and Sarcoplasmic Reticulum Ca2+ Transport. Circulation Research (1995)77:88-97.

Xu KY, Zweier JL, Becker LC. Oxygen-Free Radicals Directly Attack the ATP Binding Site of Cardiac Na,K-ATPase. Annal. New York Acad. Sci. (1997)834:680-683.

Xu KY, Zweier JL, Becker LC. Hydroxyl Radical Inhibits Sarcoplasmic Reticulum Ca-ATPase Function by Direct Attack on the ATP Binding Site. Circulation Research (1997)80:76-81.

Xu KY, Becker LC. Ultrastructural Localization of Glycolytic Enzymes on Sarcoplasmic Reticulum Vesicles. J Histochem. Cytochem. (1998)46:419-427.

Xu KY, Vandegaer K, Becker LC. Glycolytic ATP Supports the Functional Recovery of the SR Calcium Pump More Efficiently Than Exogenous ATP Following Ischemia-Reperfusion. Annal. New York Acad. Sci. (1998)853:376-379.

Xu KY, Zweier JL, Becker LC. Oxygen-Free Radicals Directly Attack the ATP Binding Site of the Cardiac Na,K-ATPase. Annal. New York Acad. Sci. (1998)834:680-683.

Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC. Nitric Oxide Synthase in Cardiac Sarcoplasmic Reticulum. Proc. Natl. Acad. Sci. (1999)96:657-662.

Li H, Xu KY, Zhou L, Kalai T, Zweier JL, Hideg K, Kuppusamy P. A Pyrroine Derivative of Mexiletine Offers Marked Protection Against Ischemia/Reperfusion-Induced Myocardial Contractile Dysfunction. J. Pharmacol. Experimental. Therap. (2000)295:563-571.

Xu KY. Does Nitric Oxide Synthase Catalyze the Synthesis of Superoxide? FEBS Letters (2000)474:252-253.

Xu KY. Nitric Oxide Protects Nitric Oxide Synthase Function from Hydroxyl Radical-Induced Inhibition. Biochim Biophys Acta (2000)1481:156-166.

Xu KY. A Key negative Control Experiment Provides Evidence that Nitric Oxide Synthase Does Not Catalyze Superoxide Formation. FEBS Letters (2000)481:306-307.

Xu KY, Wang SQ, Cheng H. Site-Specific Antibody of (Na++K+)-ATPase Augments Cardiac Myocyte Contraction without Inactivating Enzyme Activity. Biochem. Biophys. Res. Commun. (2001)289:167-172.

Myers AC, Bochner BS, Tomaselli GF, Fedarko N, Hudson SA, Rohde H, Huang SK, Xu KY. Cell Surface Expression of A Specific Antigenic Site on the Catalytic Subunit of (Na++K+)-ATPase. (2002) Biochem. Biophys. Res. Commun. (2002)291:111-115.

Zhou L, Burnett AL, huang PL, Becker LC, Kuppusamy P, Kass DA, Donahue JK, Proud D, Sham JSK, Dawson TM, Xu KY. Lack of Nitric Oxide Synthase Depresses Ion Transporting Enzyme Function in Cardiac Muscle. Biochem. Biophys. Res. Commun. (2002)294:1030-1035.

Wang SQ, Cheng H, Myers AC, Canning BJ, Xu KY. Positive Inotropic Effect Induced by Sequence-Specific Na,K-ATPase Antibody in Intact Cardiac Myocytes. Annal. New York Acad. Sci. (2003)986: 630-632.

Xu KY, Kuppusamy SP, Wang JQ, Li H, Cui, H, Dawson TM, Huang PL, Burnett AL, Kuppusamy P, Becker, LC. Nitric Oxide Protects Cardiac Sarcolemmal Membrane Enzyme Function and Ion Active Transport Against Ischemia Induced Inactivation. J. Biol. Chem. (2003)278: 41798-41803.

Xu KY, Takimoto E, Juang GJ, Zhang Q, Rohde H, Myers AC. Evidence that the H1-H2 Domain of ¿1 Subunit of (Na++K+)-ATPase Participates in the Regulation of Cardiac Contraction, (2005) FASEB (2005)19:53-61.

Xu KY, Kuppusamy P. Dual Effects of Copper-Zinc Superoxide Dismutase. BBRC, (2005) 336:1190-1193

Xu KY. Activation of (Na++K+)-ATPase (as Breakthroughs) Biochem. Biophys. Res. Commun. (2005)338:1669-1677.

Xu KY, Takimoto E, Fedarko NS. Activation of (Na++K+)-ATPase Induces Positive Inotropic Effect in Intact Mouse Heart in vivo. Biochem. Biophys. Res. Commun. (2006)349:582-58.

Xu KY. Dual Activity of the H1-H2 Domain of the (Na++K+)-ATPase. Biochem. Biophys. Res. Commun. (2008)377:469-473.

Lee DI, Klein MG, Zhu W, Xiao RP, Gerzanich V, Xu KY. Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function. Mol. Pharmacol. (2009)75:774-781.