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Jeffrey S. Wolf

Jeffrey S. Wolf M.D.

Academic Title: Associate Professor
Primary Appointment: Otorhinolaryngology-Head & Neck Surgery
Administrative Title: Medical Director Of Frenkil Clinic
Additional Title(s): Co-Director of General Otolaryngology
Location: James T. Frankil Building, 16 S. Eutaw Street, Suite 500
Phone: (410) 328-1887
Fax: (410) 328-5827

Research Interests:

My primary interest is immunomodulation in head and neck cancer. In our lab, we have evaluated and elucidated the mechanism of the glycoprotein lactoferrin on head and neck cancer. Specifically, we have found that lactoferrin inhibits head and neck cancer by in a T-cell dependent mechanism. We are hoping to bring this compound into clinical trials in the near future. We have recently opened a phase I clinical trial evaluating autologous dendritic cell vaccines in advanced head and neck cancer.
Our second area of research is sinusitis. We are evaluating the effects of tobacco smoke exposure on the severity of sinusitis and looking at ways to modulate the immune system to treat patients with chronic sinusitis using co-stimulatory molecules.

Clinical Speciality:

Head and Neck Surgical Oncology, Rhinology, Sleep Apnea


Selected Publications

Wolf, J.S., Li, G., Varadhachary, A., Petrak, K., Schneyer, M., Li, D., Ongkasuwan, J., Zhang, X., Taylor, R.J., Strome, S.E., O’Malley, Jr., B.W.:  Oral Lactoferrin Results in T-cell Dependent Tumor Inhibition of Head and Neck Squamous Cell Carcinoma in vivo.  Clinical Cancer Research; 2007:13:1601-10.

Taylor, R.J., Chiu, A.G., Palmer, J.N., Schofield, K., O’Malley, B.W., Wolf, J.S.: Informed Consent in Sinus Surgery: Link between Demographics and Patient Desires.  Laryngoscope 2005: 115(5): 826-831.

Wolf, J.S., Chiu, A.G., Palmer, J.N., Schofield, K., O’Malley, B.W., Taylor, R.J.: Informed Consent in Endoscopic Sinus Surgery:  The Patient Perspective.  Laryngoscope 2005: 115(3):492-494.

Varadhachary, A., Wolf, J.S., Petrak, K.: O’Malley, B.W., Spadaro, M., Curcio, C., Forni, G., Pericle, F.:  Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy.  International Journal of Cancer 2004: 111:398-403.

Wolf. J.S., Berry, J., Malekzadeh, S., O'Malley, B.W.: Informed consent in functional endoscopic sinus surgery. Laryngoscope 2002:112:774-778.

Wolf. J.S., Chen, Z., Dong, G., Sunwoo, J.B., Crowl-Bancroft, C., Capo, D.E., Yeh, N.T., Mukaida, N., Van Waes, C.: Head and neck squamous cell carcinoma produces functional secretory and intracellular IL-1 a to promote cell survival and proangiogenic and proinflammatory cytokine IL-8 production through transcriptional regulation. Clin Cancer Res. 2001; 7:1812-20.