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Tami J Kingsbury
Ph.D.
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| Academic Title:
Assistant Professor |
| Primary Appointment:
Physiology |
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tking001@umaryland.edu |
| Location:
HSF-II,
S111 |
| Phone:
(410) 706-7687 |
| Fax:
(410) 706-8341 |
| Lab:
(410) 706-7685 |
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Personal History
I received my Ph.D. from the Department of Biology at Johns Hopkins University. I was trained as a yeast molecular biologist and geneticist. As a postdoctoral fellow in the laboratory of Dr. Kyle Cunningham, I discovered a novel family of proteins conserved from yeast to humans that regulates the protein phosphatase calcineurin. One of the human homologs, DSCR1, is located on Chromosome 21, the chromosome triplicated in Down Syndrome patients. I therefore decided to undertake a second postdoctoral fellowship to learn neurobiology at the University of Maryland School of Medicine with Dr. Bruce Krueger. In 2006, I was named a BIRCWH Scholar by the Maryland’s Organized Research Effort in Women’s Health and was appointed Assistant Professor in the Department of Physiology. Research in my laboratory is supported by the National Institutes of Health (NIH) and the Department of Defense.
Research Interests
Calcium signaling and gene expression
Lab Techniques and Equipment
Molecular biology, genetics and biochemistry
Laboratory Personnel:
- Becky Saunders
- Sean Connolly
Publications
T.J. Kingsbury and K.W. Cunningham. A conserved family of calcineurin regulators. Genes and Development 14:1595-1604 (2000)
J.J. Fuentes, L. Genesca, T.J. Kingsbury, K.W. Cunningham, M. Perez-Riba, X. Estivill and S. de la Luna. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Human Molecular Genetics 9: 1681-1690 (2000).
T.J Kingsbury, P.D. Murray, L.L. Bambrick and B.K.Krueger. Ca(2+)-dependent regulation of TrkB expression in neurons. Journal of Biological Chemistry 278:40744-8 (2003)
Z. Hilioti, D.A. Gallagher, S.T. Low-Nam, P. Ramaswamy, P. Gajer, T.J. Kingsbury, C.J. Birchwood, A. Levchenko and K.W. Cunningham. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes and Development 18:35-47 (2004).
T.J. Kingsbury and B.K. Krueger. Ca2+, CREB and Kruppel: A novel KLF7-binding element conserved in mouse and human TRKB promoters re¬quired for CREB-dependent transcription. Molecular Cellular Neuroscience, Molecular and Cellular Neuroscience 35:447-455 (2007).
T.J. Kingsbury, L. Bambrick, C. Roby and B.K. Krueger. Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons. Journal of Neurochemistry 103:761-770 (2007).
P.D. Murray, T.J. Kingsbury and B.K. Krueger. Failure of Ca2+-activated, CREB-dependent gene transcription in astrocytes. 57:828-834 (2009).
Faculty members:
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