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Personal History
I received my Ph.D. from the Department of Biology at
Research Interests
Calcium signaling and gene expression
Lab Techniques and Equipment
Molecular biology, genetics and biochemistry
Laboratory Personnel:
- Sean Connolly
Publications
T.J. Kingsbury and K.W. Cunningham. A conserved family of calcineurin regulators. Genes and Development 14:1595-1604 (2000) J.J. Fuentes, L. Genesca, T.J. Kingsbury, K.W. Cunningham, M. Perez-Riba, X. Estivill and S. de la Luna. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Human Molecular Genetics 9: 1681-1690 (2000).
T.J Kingsbury, P.D. Murray, L.L. Bambrick and B.K.Krueger. Ca(2+)-dependent regulation of TrkB expression in neurons. Journal of Biological Chemistry 278:40744-8 (2003)
Z. Hilioti, D.A. Gallagher, S.T. Low-Nam, P. Ramaswamy, P. Gajer, T.J. Kingsbury, C.J. Birchwood, A. Levchenko and K.W. Cunningham. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes and Development 18:35-47 (2004). PMCID: PMC314273
T.J. Kingsbury and B.K. Krueger. Ca2+, CREB and Kruppel: A novel KLF7-binding element conserved in mouse and human TRKB promoters re¬quired for CREB-dependent transcription. Molecular Cellular Neuroscience, Molecular and Cellular Neuroscience 35:447-455 (2007). PMCID: PMC2042965
T.J. Kingsbury, L. Bambrick, C. Roby and B.K. Krueger. Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons. Journal of Neurochemistry 103:761-770 (2007).
P.D. Murray, T.J. Kingsbury and B.K. Krueger. Failure of Ca2+-activated, CREB-dependent gene transcription in astrocytes. 57:828-834 (2009). PMCID: PMC2669848
L.E.F. Almeida, P.D. Murray, H.R. Zielke, C.D. Roby, T.J. Kingsbury, B.K. Krueger. Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. Journal of Neuroscience 29:12702-12710 (2009). PMC2804479
S. Connolly and T.J. Kingsbury. Caffeine modulates CREB-dependent gene expression in developing cortical neurons. Biochem Biophys Res Commun 397: 152-156 (2010). PMC2922856
S. Connolly and T.J. Kingsbury. Regulatory subunit myristoylation antagonizes calcineurin phosphatase activation in yeast. J Biol Chem 287: 39361-39368 (2012). PMCID: PMC3501033
W.C. Cheng, T.J. Kingsbury, S.J. Wheelan and C.I. Civin, A simple high-throughput technology enables gain-of-function screening of human microRNAs. Biotechniques. 2013 Feb;54(2):77-86. doi: 10.2144/000113991.
