SOM Faculty Profile : Donna L Farber

Donna L Farber

Donna L Farber Ph.D.

Academic Title: Professor

Primary Appointment: Surgery

Secondary Appointments: Microbiology and Immunology

dfarber@smail.umaryland.edu

Location: Howard Hall, 304

Phone: (410) 706-7458

Phone: (410) 706-0532

Fax: (410) 706-0311

Personal History

Donna Farber did her undergraduate training at the University of Michigan in Ann Arbor, MI in the field of Microbiology, then did her graduate work in Biochemistry and Molecular Biology at the University of California, Santa Barbara. She went onto pursue postdoctoral training in immunology at Yale University School of Medicine and also spent one year as a research associate in signal transduction at the Pasteur Institute in Paris, France. Dr. Farber has been a faculty member in the Department of Surgery since 2000.

Research Interests

The primary research interest of the Farber lab is in immunological memory, which is the ability of the immune system to recall its previous encounters with pathogens and respond more effectively and rapidly to them. We are using in vivo models to examine the cellular, molecular and biochemical bases of the memory immune response mediated by memory CD4 T cells. We are particularly interested in the biochemical signals that control the generation of memory and its recall response, and also how memory T cell mediate protective immunity to viruses, such as influenza. We are also studying how modulation of memory T cell responses can be targeted in immunotherapies to ameliorate their deleterious functions in autoimmune diseases, transplantation and immunopathology in anti-viral immunity.

Publications

Selected Publications (Last Three Years)

Patke, D.S. and Farber, D.L. (2005) "Modulation of memory CD4 T cell function and survival potential by altering the strength of the recall stimulus." J. Immunol. 174:5433-5443.

Bingaman, A.W., Patke, D.S., Mane, V., Bartlett, S.T., and Farber, D.L. (2005) "Novel phenotypes and migration properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue." Eur. J. Immunol.35:3173-86. Highlighted In this Issue 35:3085-6.

Patke, D., Ahmadzadeh, M, Bingaman, A.W. and Farber, D.L. (2005) Anti-CD3priming generates heterogeneous antigen-specific memory CD4 T cells . Clinical Immunology. 117:125-32. (commentary in same issue by Milone, M.C. and June, C.H.. "Adoptive immunotherapy: new ways to skin the cat?" pp.101-103.)

Tang, A.L., Bingaman, A.W., Kadavil, E.A., Leeser, D.B., and Farber, D.L. (2006) "Generation and functional capacity of polyclonal alloantigen-specific memory CD4 T cells." Am. J. Transplant. 6:1275-1284. (editorial in the same issue by Fairchild, R., "Developing models to study the memory T cell barrier in transplantation", 6:1246-7)

Moulton, V., Bushar, N.D., Leeser, D., Patke, D.S. and Farber, D.L. (2006) "Divergent generation of heterogeneous memory CD4 T cells." J. Immunol. 177: 869-876.

Moulton, V. and Farber, D.L. (2006) Committed to memory: lineage choices for T cells. Trends Immunol. 27: 261-67.

Ndejembi, M.P., Patke, D.S., Bingaman, A.W., Chandok, M.R., Azimzadeh, A., Nadler,S.G., and Farber, D.L. (2006) Control of Memory CD4 T cell recall by the CD28 costimulatory pathway. J. Immunol. 177: 7698-7706.

Zhang, X., Dong, H., Lin. W., Voss, S., Hinkley, L., Westergren, M., Berry, D., Lewellen, D., Vile, R. Chen, L., Farber, D.L., and Strome, S.E. (2006) "Human Bone Marrow: a reservoir for enhanced effector-memory CD8 T Cells with potent recall function." J. Immunol. 177: 6730-7.

Shi, Q., Wang, D., Hadley, G.A., Farber, D.L. and Bartlett, S.T. (2006) "Abrogation of recurrent autoimmunity in the NOD mouse: a critical role for IL-4." Surgery. 140:281-288.

Ndejembi, M.P., Tang, A.L. and Farber, D.L. (2007) "Reshaping the Past: strategies for modulation of T cell memory." Clinical Immunology. 122:1-12.

Tang, A.L. and Farber, D.L. (2007) "Generation, homeostasis, and regulation of memory T cells in Transplantation." Current Opinion in Organ Transplantation. 12:23-29.

Chandok, M.R., Okoye, F.I., Ndejembi, M.P. and Farber, D.L. (2007) "A biochemical signature for rapid recall by memory CD4 T cells." J. Immunol. 179:3689-98.

Okoye, F.I., Krishnan, S., Chandok, M.R., Tsokos, G.C., and Farber, D.L. (2007) "Proximal Signaling control of human CD4 T cell function." Clin. Immunol. 125:5-15.

Tang, A.L., Njau, M.N., Teijaro, J.R., Azimzadeh, A., Nadler, S.G. and Farber, D.L. (submitted) "CTLA expression is an indicator and regulator of CD4+FoxP3+ T cell homeostasis."

Lin, M., Zhang, N, Teijaro, J. R., Stoica, C., Bona, C., McEvoy, R., Bromberg, J., Farber, D.L., Casares, S., and Brumeanu, T.-D. (2008) "A peptide-MHC II chimera avorssurvival of pancreatic ï? islets grafted in type 1 diabetic mice." Transplantation. In Press.

Verhoeven, D., Teijaro, J.R., and Farber, D.L. (2008) "Heterogeneous memory T cells in anti-viral immunity and immunopathology." Viral Immunology. In Press

Teijaro, J.R., Njau, M.P., Chandran, S., Nadler, S.G., Perez, D.R., Hasday, J and Farber, D.L. (submitted) Inhibiting CD28 costimulation uncouples memory T cell-mediated protection and immunopathology in influenza infection.

Links of Interest

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