SOM Faculty Profile : Kirsten E Lyke

Kirsten E Lyke M.D.

Academic Title: Assistant Professor

Primary Appointment: Medicine

klyke@medicine.umaryland.edu

Location: HSF 1, Room 480

Phone: (410) 706-7376

Fax: (410) 706-0462

Lab: HSF 1, Room 473

Research Interests

Dr. Lyke studies the human immune response to parasites and participates in field, clinical and immunologic studies of Plasmodium falciparum and Schistosoma haematobium. Immunologic studies involve the investigation of different components of the cell-mediated immune response, including cytokine production, mechanisms of lymphocyte activation, cytotoxic T cell activity and lymphoid cell populations involved in generation of protective immune responses. In collaboration with colleagues at the University of Mali, Dr. Lyke has aided in the development of a field research site in the Dogon Country of Mali. This field station has been the site of studies of drug resistance and the pathogenesis of severe malaria, and has completed malaria vaccine trials.

Clinical Speciality

Malaria, parasites

Publications

Lyke KE, Dabo A, Sangara L, Arama C, Dao M, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children. Infection and Immunity, 2006 Oct;74(10):5718-24.

Lyke K.E., Dicko A., Kone A., Coulibaly D., Guindo A., Traore K., Dra M., Diarra I., Dabo A., Sztein MB., Plowe C.V., and Doumbo OK. Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum infection in Malian children. Am J Trop Med Hyg 73: 1124-1130, 2005.

Lyke KE, Burges R, Cissoko, Y, Sangare L, Kone A, Fernandez-Vina M, Plowe C, Doumbo O, and Sztein MB. Interferon-gamma (IFN-gamma) production and proliferation of HLA-A*2 restricted peripheral blood mononuclear cells (PBMC) derived from Malian children with severe or uncomplicated P. falciparum malaria and healthy controls. Infection and Immunity 73: 5799-5808, 2005.

Mahamadou A. Thera, Ogobara K. Doumbo, Drissa Coulibaly, Dapa A. Diallo, Issaka Sagara, Alassane Dicko, David J. Diemert, D. Gray Heppner Jr, V. Ann Stewart, Evelina Angov, Lorraine Soisson, Amanda Leach, Kathryn Tucker, Kirsten E. Lyke, Christopher V. Plowe, for the Mali FMP1 Working Group. Safety and Allele-Specific Immunogenicity of a Malaria Vaccine in Malian Adults: Results of a Phase I Randomized Trial. PLoS Clin Trials 1(7): e34. doi:10.1371/journal.pctr.0010034.

Lyke KE, Burges R, Cissoko, Y, Sangare L, Dao M, Diarra I, Kone A, Fernandez-Vina M, Plowe C, Doumbo O, and Sztein MB. Serum levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1Î²), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12 (p70) in Malian Children with Severe Plasmodium falciparum Malaria and Matched Uncomplicated Malaria or Healthy Controls. Infection and Immunity 72: 5630-5637, 2004.

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