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Research Interests
Signal transduction pathways that regulate the growth and survival of cancer cells, molecular mechanisms of drug resistance.Publications
Peer-Reviewed Articles:
Popovici, C., Zhang, B., Gregoire, M.J., Jonveaux, P., Lafage-Pochitaloff, M., Birnbaum, D., Pebusque, M.J. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood, 93:1381-1389, 1999.Zhang, B, Prendergast, G.C., Fenton, R.G. Farnesyltransferase inhibitors reverse Ras-mediated inhibition of Fas gene expression. Cancer Res., 62:450-458, 2002.
Zhang, B, Gojo, I., Fenton, R.G. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood, 99:1885-1893, 2002.
Gojo, I.*, Zhang, B.*, and Fenton, R.G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res., 8:3527-3538, 2002.
Zhang, B., and Fenton, R.G. Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2). J. Cell. Physiol., 193:42-54, 2002.
Zhang, B., Potyagaylo, V., and Fenton R.G. IL-6-independent expression of Mcl-1 in human multiple myeloma. Oncogene, 22:1848-1859, 2003.
Zhang, B., Arany, Z., Mann, D., Rhee, J.G., Fenton, R.G. Partitioning apoptosis: A novel form of the execution phase of apoptosis. Apoptosis, 10:219-231, 2005
Badros, A. Z., Goloubeva, O., Rapoport, A. P., Ratterree, B., Gahres, N., Meisenberg, B., Takebe, N., Heyman, M., Zwiebel, J., Streicher, H., Gocke, C. D., Tomic, D., Flaws, J. A., Zhang, B., and Fenton, R. G. Phase II Study of G3139, a Bcl-2 Antisense Oligonucleotide, in Combination With Dexamethasone and Thalidomide in Relapsed Multiple Myeloma Patients. Journal of Clinical Oncology, 23:4089-4099, 2005.