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David A Rasko
Ph.D.
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| Academic Title:
Assistant Professor |
| Primary Appointment:
Microbiology and Immunology |
| Additional Title(s):
Assistant Professor, Institute for Genome Sciences |
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drasko@som.umaryland.edu |
| Location:
BioPark II, 801 W. Baltimore St.,
Suite 619 |
| Phone:
(410) 706-6774 |
| Fax:
(410) 706-1482 |
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Personal History
- B.Sc., 1995, Specialization in Microbiology, with Honors, University of Alberta, Canada
- Ph.D., 1995-2000, Medical Microbiology and Immunology, University of Alberta, Canada (Advisors : Dr. Glen Armstrong and Dr. Diane Taylor)
- Post-Doctoral Fellow, 2000-2001, University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, Maryland (Mentor : Harry L.T. Mobley)
- GenBank Biologist, 2001-2003, National Center for Biotechnology Information, Bethesda, Maryland
- Staff Scientist/Collaborative Investigator, 2003-2005, The Institute for Genomic Research (TIGR), Rockville, Maryland
- Research Assistant Professor, 2005-2008, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Research Interests
My research focuses on utilizing comparative genomics of closely related isolates to examine pathogen evolution, with a focus on plasmids and other mobile elements; identification of new virulence factors and signaling cascades in the hope of developing novel therapeutics; and examining the functional aspects of these novel features using modern molecular biology tools animal models. My work utilizes pathogens such as the Bacillus cereus group, Escherichia coli and Shigella.
Publications
D.A. Rasko, M.J. Rosovitz, G.S.A. Myers, E.F. Mongodin, W.F. Fricke, P. Gajer, J. Crabtree, V. Sperandio and J. Ravel. 2008. The pan-genome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates. Journal of Bacteriology. 2008 Oct;190(20):6881-93.
D.A. Rasko, C.G. Moreira, D.R. Li, N.C. Reading, J.M. Ritchie, M.K. Waldor, N. Williams, R. Taussig, S. Wei, M. Roth, D.T. Hughes, J.F. Huntley, M.W. Fina, J.R. Falck and V. Sperandio. 2008. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22;321(5892):1078-80.
J.F. Huntley, P.G. Conley, D.A. Rasko, K.E. Hagman, M.A. Apicella, M.V. Norgard. 2008. Native outer membrane proteins protect mice against pulmonary challenge with virulent Type A Francisella tularensis. Infection and Immunity 2008 Aug;76(8):3664-71.
M.M. Kendall*, D.A. Rasko* and V. Sperandio. 2007. Global effects of the cell-to-cell signaling molecules autoinducer-2, autoinducer-3, and epinephrine in a luxS mutant of enterohemorrhagic Escherichia coli. Infection and Immunity. 75(10):4875-84. (* Equal contribution to the study)
D.A. Rasko*, C.D. Esteban* and V. Sperandio. 2007. Development of novel plasmid vectors and a promoter trap system in Francisella tularensis compatible with the pFLN10 based plasmids. Plasmid. 58(2):159-66 (* Equal contribution to the study)
M. Eppinger, M.J. Rosovitz, W.F. Fricke, D.A. Rasko, G. Korkorina, M.-L. Fayolle, L.E. Linder, E. Carniel and J. Ravel. 2007. Genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East Scarlet Like Fever (FESLF): Linking genome plasticity to pathogenicity. PLOS Genetics. 3(8):e142.
A.L. Lloyd, D.A. Rasko and H.L.T. Mobley. 2007. Defining genomic islands and uropathogen-specific genes in uropathogenic Escherichia coli. Journal of Bacteriology. 189:2532-46.
T.J. Welch, W.F. Fricke, P. McDermott, D. White, M.-L. Rosso, D.A. Rasko, M.K. Mammel, M. Eppinger, M.J. Rosovitz, D. Wagner, L. Rahalison, J.E. LeClerc, J.M. Hinshaw, L.E. Linder, T.A. Cebula, E. Carniel and J. Ravel. 2007. Multiple antimicrobial resistance in plague: PLOS One. 2:e309.
D.A. Rasko, M.J. Rosovitz, O.A. Okstad, D.E. Fouts, L. Jiang, R.Z. Cer, A.B. Kolsta¸, S.R. Gill, and J. Ravel. 2007. Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus group plasmids including B. anthracis pXO1. Journal of Bacteriology. 189:52-64.
G.S.A. Myers, D.A. Rasko, J.K. Cheung, J. Ravel, R. Seshadri, R.T. DeBoy, Q. Ren, J. Varga, M.M. Awad, L.M. Brinkac, S.C. Daugherty, D.H. Haft, R.J. Dodson, R. Madupu, W.C. Nelson, M.J. Rosovitz, S.A. Sullivan, H. Khouri, G.I. Dimitrov, K.L. Watkins, S. Mulligan, J. Benton, D. Radune, D.J. Fisher, H.S. Atkins, T. Hiscox, B.H. Jost, S. J. Billington, J.G. Songer, B.A. McClane, R.W. Titball, J.I. Rood, S.B. Melville, and I.T. Paulsen. 2006. Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Research. 16(8):1031-40.
D.A. Rasko, G.S. Myers, J. Ravel. 2005. Visualization of comparative genomic analyses by BLAST score ratio. BMC Bioinformatics. 6:2
D.A. Rasko, M. R. Altherr, C. S. Han and J. Ravel. 2005. Genomics of the Bacillus cereus group of organisms. FEMS Microbiology Reviews. 29(2):303-329.
A.R. Hoffmaster*, J. Ravel*, D.A. Rasko*, G.D. Chapman, M. Chute, C.K. Marston, B.K. De, C.T. Sacchi, C. Fitzgerald, L.W. Mayer, M.C.J. Maiden, F.G. Priest, M. Barker, L. Jiang, R.Z. Cer, J. Rilstone, S.N. Peterson, R.S. Weyant, D.R. Galloway, T.D. Read, T. Popovic and C.M. Fraser. 2004. Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax. Proceedings of the National Academy of Sciences. 101(22): 8449-8454 (*Equal contributions to the publication)
D.A. Rasko, J. Ravel, O.A. Okstad, E. Helgasson, N. Tourasse, R.Z. Cer, L. Jiang, K.A. Shores, D. Fouts, S.V. Angiuoli, J.F. Kolonay, W.C. Nelson, A.B. Kolsto¸, C.M. Fraser, T.D. Read. 2004. The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1. Nucleic Acids Research. 32(3):977-988
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