Research InterestsMy research interests are: A) to study the use of renal assist device (RAD) in the treatment of acute renal failure in association with multi-organ failure. B) Pathophysiology of cardiovascular disease in patients with chronic kidney disease, while on dialysis and after successful kidney transplantation. C) Pathophysiology of congestive heart failure in dialysis patients and the impact of kidney transplantation on the outcome of congestive heart failure. D) Progression of atherosclerosis and cardiovascular disease under the influence of different immunosuppression modalities following kidney transplantation. E) Pathophysiology and therapeutic options for the treatment of chronic allograft nephropathy in recipients of kidney transplants.
Clinical SpecialityMy clinical interests are the management of patients with acute renal failure in the intensive care settings, and use of new therapies for the treatment of acute renal failure and multi-organ dysfunction. Management and treatment of organ transplant patients with a special interest in high-risk kidney and kidney-pancreas transplant patients. Management of patients with polyoma virus disease following solid organ transplantation. Other clinical interests include management issues in HIV patients who develop different types of chronic kidney disease either without or while being treated with ART.
Henrich WL, Cheung, Churchill D, Wali RK. National Kidney Foundation Guidelines on Cardiovascular Disease in Patients on Dialysis. AJKD 2005; 45 (Suppl 3): S7-S151.
Wali RK*: Outcome of Dilated Cardiomyopathy in Dialysis Patients Following Successful Kidney Transplantation. J Am Coll Cardiol. 2005 Apr 5;45(7):1051-60.
Drachenberg C, Hirsch HH, Papadimitrious JC, Mozafari P, Wali RK, McKinney JD, Nogueira J, Cangro C, Mendley S, Klassen D, Ramos E. Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc. 2004 Dec;36(10):3028-31.
Wali RK*, Drachenberg C, Hirsch H, Papadimitriou J, Nahar A, Mohanlal V, Brisco MA, Bartlett S, Weir MR, Ramos E: BK virus-associated nephropathy in renal allograft recipients: Rescue therapy by sirolimus-based immunosuppression. Transplantation 2004;78(7):1069-1073.
Ramos E, Vincenti F, Lu WX, Shapiro R, Trofe J, Stratta RJ, Jonsson J, Randhawa PS, Drachenberg CB, Papadimitriou JC, Weir MR, Wali RK#: Retransplantation in patients with graft loss caused by polyoma virus nephropathy. Transplantation 2004; 77: 131-3.
Drachenberg CB, Papadimitriou JC, Wali RK, Nogueira J, Mendley S, Hirsch HH, Cangro CB, Klassen DK, Weir MR, Bartlett ST, Ramos E: Improved outcome of polyoma virus allograft nephropathy with early biopsy. Transplant Proc. 2004; 36: 758-9.
Wali RK: Oxidative stress in dialysis patients. Chapter in: Henrich WL. Principles and Practice of Dialysis, third edition, Lippincott, Williams & Wilson, Philadephia, 2004.
Wali RK: Lipidemia and Organ Transplantation. Chapter in: Medical Management in Renal Transplantation, by Dr. Matthew R. Weir, LWW, Philadelphia, PA (in print).