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Rosangela  Mezghanni
 

Rosangela Mezghanni Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Pediatrics
Additional Title(s): Rosangela Salerno-Goncalves (Maiden Name)
rmezghan@medicine.umaryland.edu
Location: HSF1, 480
Phone: (410) 706-3374
Fax: (410) 706-2345
Lab: (410) 706-7376

Personal History:

  • 1983-1987: B.Sc., Rio de Janeiro Federal University - UNI-RIO; Rio de Janeiro,  Brazil (Major: Medical Analysis)
  • 1992-1994: DEA (Diplome d'Etudes Approfondie, Microbiology); Paris V University, Laennec Hospital, Laboratory of Oncology and Molecular Virology; Paris,  France
  • 1994-1999: Ph.D. (Microbiology & Immunology), Paris V University; Laennec Hospital Laboratory of Oncology and Molecular Virology; Paris, France

Research Interests:

My main interest is in translational human immunology.  It has always been my strong desire to focus my research on studies that could bridge new developments in the field of immunology to the treatment of human diseases. My work entails analysis of the innate immune response at earliest times after infection through to the development of long-term adaptive immune response. My research strives to bring us closer to understand the cellular controllers of continual immune response to allow successful vaccination.


Publications:

W. Lu, R. Salerno-Goncalves, J. Yuan, S. Dore, D.S. Han and J. M. Andrieu. "Glucocorticoids rescue CD4+ T lymphocytes from activation-induced apoptosis triggered by HIV-1: implications for pathogenesis and therapy." AIDS 1995, 9(1) : 35-42.

R. Salerno-Goncalves, W. Lu, A. Achour and J. M. Andrieu. "Lysis of CD4+ T cells expressing HIV-1 gag peptides by gag-specific CD8+ cytotoxic T cells." Immunology Letters 1998, 64 : 71-77.

A. Achour, Landureau J.C, R. Salerno-Goncalves, Maziere J.C. and D. Zagury. "Restoration of immune response by a cationic amphiphilic drug (AY 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1." Antimicrob. Agents Chemother. 1998, 42(10) : 2482-91.

R. Salerno-Goncalves, W. Lu, A. Achour and J. M. Andrieu. "HLA-unrestricted killing of HIV-1 gag protein-expressing CD4+ T cells by gag-specific CD8+ cytotoxic T cells." AIDS 1999, 13 : 1583-1584.

R. Salerno-Goncalves, W. Lu and J. M. Andrieu. "Quantitative analysis of the antiviral activity of CD8+ T cells from HIV+-asymptomatic patients with different rates of CD4+ T cell decrease." J. Virol. 2000, 74(14): 6648-51.

M.F. Pasetti, R. Salerno-Goncalves, and M.B. Sztein. "Salmonella enterica serovar  Typhi vector vaccines delivered intranasally elicit regional and systemic specific CD8+ major histocompatibility class I-restricted cytotoxic T lymphocytes." Infection and Immunity 2002, 70(8):4009-1870.

R. Salerno-Goncalves, M. Passeti, and M.B. Sztein. “Characterization of CD8+ effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine”. J. Immunol. 2002, 169(4): 2196-2203.

R. Salerno-Goncalves, T.L. Wyant, M. Passeti, M. Fernandez-Vina, C.O. Tacket, M.M. Levine and M.B. Sztein. "Concomitant induction of CD4+ and CD8+ T cell responses in volunteers immunized with Salmonella enterica serovar typhi strain CVD 908-htr." J Immunol. 2003, 170(5):2734-41.

R. Salerno-Goncalves, M. Fernandez-Viña, D. Lewinsohn, and M.B. Sztein. "Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine."  J. Immunol. 2004, 173(9):5852-62.

R. Salerno-Goncalves, R. Wahid and M.B. Sztein. "Immunization of volunteers with Salmonella enterica serovar Typhi strain Ty21a elicits the oligoclonal expansion of CD8+ T cells with predominant V-Beta repertoires." Infection and Immunity 2005, 73(6):3521-30.

R. Salerno-Goncalves, and M.B. Sztein. "Cell-mediated immunity and the challenges for vaccine development." Trends Microbiol. 2006, 14(12):536-42.

R. Wahid, R. Salerno-Goncalves, C.O. Tacket, M.M. Levine and M.B. Sztein. "Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909." Vaccine 2007, 25(8):1416-25.

R. Wahid, R. Salerno-Goncalves, C.O. Tacket, M.M. Levine and M.B. Sztein. "Generation of specific effector and memory T cells with gut and secondary lymphoid tissues homing potential by oral attenuated CVD 909 typhoid vaccine in humans." Mucosal Immunol. 2008; 1:389-398.

R. Salerno-Goncalves, and M.B. Sztein. "Priming of Salmonella enterica serovar typhi-specific CD8(+) T cells by suicide dendritic cell cross-presentation in humans."  PLoS ONE 2009, 4:e5879.

R. Salerno-Goncalves, M.J. Hepburn, S. Bavari and and M.B. Sztein. "Generation of heterogeneous memory T cells by live attenuated tularemia vaccine in humans." Vaccine 2009, 28(1):195-206.

R. Salerno-Goncalves, R. Wahid and M.B. Sztein. “Ex vivo kinetics of early and long-term multifunctional HLA-E specific CD8+ cells in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine”. Clin Vaccine Immunol. 2010, 17(9):1305-14.

R. Salerno-Goncalves, A. Fasano and M.B. Sztein. “Engineering of a multicellular organotypic model of intestinal mucosa”. Gastroenterology 2011 Aug;141(2):e18-20.

R. Salerno-Goncalves, T. Rezwanul and M.B. Sztein.. “B cells modulate mucosal associated invariant T cell immune responsesFront Immunol. 2014 Jan 7;4:511.

J.S. Booth, F.R. Toapanta, R. Salerno-Goncalves, S. Patil, H. Kader, A. Safta, S.J. Czinn, B.D. Greenwald and M.B. Sztein. “Characterization and functional properties of gastric tissue-resident memory T cells from children, adults and the elderly”.  Front Immunol. 2014 Jun 19;5:294.

M.B. Sztein,R. Salerno-Goncalves, M.A. Mcarthur. “Complex Adaptive Immunity to enteric fevers in humans: Lessons learned and the path forward”.Front Immunol.20145:516.