Clinical research into the genetics, pathophysiology and prevention of obesity and diabetes. My investigative approaches include insulin clamps, indirect calorimetry, body composition analyses, microdialysis, intraneural recordings of sympathetic nervous system activity, genetics, genomics and measurements of physical activity.
Snitker S, Watanabe RM, Ani I, Xiang AH, Marroquin A, Ochoa C, Goico J, Shuldiner AR, Buchanan TA. Changes in Insulin Sensitivity in Response to Troglitazone Do Not Differ between Subjects with and without the Common, Functional Pro12Ala PPAR-γ-2 Gene Variant: Results from the Troglitazone in Prevention of Diabetes (TRIPOD) Study. Diabetes Care 2004; 27:1365-8.
Snitker S, Le KY, Hager E, Caballero B, Black MM. Influence of Physical Activity and Body Composition on Glucose Homeostasis in a Community Sample of Adolescents. Archives of Pediatric and Adolescent Medicine 2007 ;161:677-83.
Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell J, Ducharme J, Hines S, Sack P, Naglieri R, Shuldiner AR, Snitker S. Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med. 2008;168:1791-7.
Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009;89:45-50.
Black M, Hager E, Le K, Anliker J, Arteaga SS, DiClemente CC, Gittelson J, Magder L, Papas M, Snitker S, Treuth M, Wang Y. Challenge!: A Mentorship Model of Health Promotion and Obesity Prevention Among Urban, African-American Adolescents. Pediatrics 2010;126:280-8.
Snitker S. Use of body fatness cutoff points. Mayo Clinic Proceedings (in press)