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Robert E. Rosenthal M.D.

Academic Title: Professor
Primary Appointment: Emergency Medicine
Secondary Appointments: Anesthesiology
Location: Shock Trauma Center PBG02
Phone: (410) 328-6152
Fax: (410) 328-3758
Lab: (410) 328-2614

Personal History:

• Yale University, New Haven, CT, BA, Chemistry, 1975
• New York University School of Medicine, New York, NY, MD, 1979
• George Washington University, Washington DC, Residency, Internal Medicine, 1979-1982

Research Interests:

1) Global and Focal Cerebral Ischemia: Evaluation of novel neuroprotective strategies in bot the pre-clinical and clinical settings.
2) Traumatic Brain Injury: Development of novel pre-clinical models for the study of TBI

Clinical Speciality:

1) Emergency Medicine

2) Hyperbaric Medicine

    a) Wound Healing

    b) Radiation Tissue Damage

    c) Inhalation Injuries/Carbon Monoxide

    d) Diving Medicine


Miljkovic-Lolic M, Silbergleit R, Fiskum G, Rosenthal RE. Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity. Brain Res 2003; May 2;971(1):90-4.

Rosenthal RE, Silbergleit R, Hof PR, Haywood Y, Fiskum G. Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke 2003; May;34(5):1311-6.

Li EN, Menon NG, Rodriguez ED, Norkunas M, Rosenthal RE, Goldberg NH, Silverman RP. The effect of hyperbaric oxygen therapy on composite graft surviva. Ann Plast Surg 2004;53:141-145.

Fiskum G, Rosenthal RE, Vereczki V, Martin E, Hoffman GE, Chinopoulos C, Kowaltowski A. Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J Bioenerg Biomembr 2004;26:347-352.

Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol 2004;189:261-279.

Martin E, Rosenthal RE, Fiskum G. Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res 2005;79 (1-2):240-247.

Rosenthal RE, Bogaert YE, Fiskum G. Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs. Neurosci Lett 2005;378:82-87.

Zanelli Sa, Solenski NJ, Rosenthal RE, Fiskum G. Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann NY Acad Sci 2005;1053;153-161.

Rosenthal R.E. and Fiskum, G., Oxygen: Could there be too much of a good thing? Hosp Med. 2005;66:76-77.

Vereczki, V., Martin, E., Rosenthal R.E., Hof, P.R., Hoffman, G.E., and Fiskum, G., Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab 2006;26:821-835.

Richards EM, Rosenthal RE, Kristian T, Fiskum G. Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Rad Biol Med 2006;40:1960-1970.

Balan IS, Fiskum G, Hazleton J, Cotto-Cumba C, Rosenthal RE. Oximetry-guided reoxygenation improves neurologic outcome after experimental cardiac arrest. Stroke 2006;37:3008-3013.

Richards EM, Fiskum G, Rosenthal RE, Hopkins I, Mckenna MC. Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism. Stroke2007;38:1578-84.