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Rui-Xin Zhang Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Family & Community Medicine
Location: 520 W. Lombard Street, East Hall, Baltimore, MD 21201
Phone: (410) 706-1582
Fax: (410) 706-1583

Personal History:

Dr. Zhang received his Bachelor of Medicine and Ph.D. from Shanxi Medical University, People's Republic of China. He has had extensive training in the areas of pain and substance abuse at NIH and Yale University. Dr Zhang completed a post-doctorate fellowship with the CFIM and has now joined our faculty as assistant professor. At present, he investigates the mechanisms of acupuncture at the systemic, cellular and molecular level with behavioral, pharmacological, physiological, histochemical and molecular approaches.

Positions and Employment

  • 1984-1987: Teaching/Research Assistant, Dept. Physiology, Shanxi Medical Univ., Taiyuan, China
  • 1987-1993: Instructor, Dept. of Physiology, Shanxi Medical University, China
  • 1993-1994: Postdoctoral Fellow, Dept. of Neurosci. & Cell Biology Robert Wood Johnson Medical School Univ. of Med. and Dentistry of New Jersey (UMDNJ), Piscataway, NJ
  • 1994-1996: Visiting Fellow (Fogarty International Center), NIH, NIDR, NAB, Bethesda, MD
  • 1996-2000: Postdoctoral Associate, Dept. of Psychiatry, Yale University, New Haven CT
  • 2000-2002: Research Associate, Complementary Medicine Program, University of Maryland School of Medicine, Baltimore, MD
  • 2002-present: Assistant Professor, Complementary Medicine Program, University of Maryland School of Medicine, Baltimore, MD

Honors and Professional Memberships

  • Fogarty International Fellowship, 1994-1996
  • Outstanding Research Award, Zhang Xi-Jun Foundation, Chinese Association of Physiological Science, 1993
  • Member, American Society for Neuroscience
  • Member, American Pain Society
  • Member, International Association for the Study of Pain



R-X. Zhang, L. Lao, X. Wang, A. Fan, L. Wang, K. Ren, B.M. Berman (2005) Electroacupuncture attenuates inflammation in a rat model. J. Alternative and Complementary Medicine, In press.

R-X. Zhang, L. Lao, L. Wang, B. Liu, X. Wang, K. Ren, B.B. Berman (2004) Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation. Brain Res., 1020:12-17.

Lao L, Zhang R-X, Zhang G, Wang X, Berman B and Ren K (2004) A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Res., 1020:18-29.

R-X. Zhang, L. Lao, X. Wang, K. Ren, B.B. Berman (2004) Electroacupuncture Combined with Indomethacin Enhances Anti-Hyperalgesia in Inflammatory Rats. Pharmacology, Biochemistry and Behavior, 78:793-797.

R.-X. Zhang, L. Lao,  J.T. Qiao, K. Malsnee and M.A. Ruda (2004) Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation Neurosci. Lett., 2004; 359: 85-88.

R.-X. Zhang, L. Lao,  J.T. Qiao and M.A. Ruda (2004) Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation. Brain Res., 999:135-141.

R.-X. Zhang, L. Lao,  J.T. Qiao and M.A. Ruda (2003) Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation. Neurosci. Lett., 353:213-216.

Y. Zhang, H. Nie H, H. Wang, J.S. Qi, R.-X. Zhang and J.T. Qiao (2003) C-fos antisense oligodeoxynucleotide decreases formalin-induced behavioral responses and both of elevated c-fos protein and dynorphin A (1~8) expressions in dorsal horn of juvenile rats. Chin. J. Neuroanat., 19:243-250.

R.X. Zhang, H. Nie, J.S. Qi, and J.T. Qiao (2002) Bilateral phosphorylation of transcription factor CREB in rat spinal cord induced by unilateral peripheral noxious stimuli. Chin J Neuroanat., 18:1-7.

H. Wang, R. Wang, H. Nie, R. Zhang, J.-T. Qiao (2000) Neurokinin A, calcitonin gene-related peptide, and dynorphin A (1-8) in spinal dorsal horn contribute to descending inhibition evoked by nociceptive afferent pathways: an immunocytochemical study. Regulatory Peptides, 89:7-12.

R.-X.  Zhang, J.-Y. Chen,  MA Ruda,  J.-T. Qiao (1999) Functional relationship between peripheral inflammation, thermal hyperalgesia and enhanced dynorphin gene expression in spinal cord in rat---behavioral and mRNA studies. Chin. J. Neuroanat., 15:19-26.

R.J. Liu, R.-X. Zhang, J.-T. Qiao and N. Danfy (1999) Interrelations of opioids with monoamines in descending inhibition of nociceptive transmission at the spinal level: an immunocytochemical study. Brain Res., 830:183-190.

D.P. Crockett, L. Wang, R.-X. Zhang and M.D. Egger (1999) Distribution of the low-affinity neurotrophin receptor (p75) in the developing trigeminal brainstem complex in the rat. Anatomical Record, 254:549-565.

H. Wang, R.-X. Zhang, R. Wang and J.-T. Qiao (1999) Decreased expression of N-methyl-D-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freundâ?Ts adjuvant-induced inflammation: an immunocytochemical study for NMDA NR1 subunit. Neurosci. Lett., 265:195-198

H. Wang, H. Nie, R.-X. Zhang and J.-T. Qiao (1999) Peripheral nitric oxide contributes to both formalin- and NMDA-induced activation of nociceptors: an immunocytochemical study in rats. J. Neurosci. Res., 57:824-829.

H. Wang, XM. AN, R.-X. Zhang and J.-T. Qiao (1999) c-Fos and NMDA receptor-like immunoreactive neurons in spinal cord following peripheral formalin injection: A double imunocytochemical study in rats. Chin. J. Neurosci. 15:96-102

R.-X. Zhang,  M.A. Ruda and J.T. Qiao (1998) Pre-emptive intrathecal Mk-801, a non-competitive N-methyl-D-aspartate receptor antagonist, inhibits the up-regulation of spinal dynorphin mRNA and hyperalgesia  in a rat model of chronic inflammation. Neurosci. Lett., 241:57-60.

R-X. Zhang, H. Wang, M.A. Ruda, M. J. Iadarola, J-T Qiao (1998) c-Fos expression in NMDA receptor-contained neurons in spinal cord in a rat model of inflammation: a double immunocytochemical study. Brain Res., 795:282-286.

R.J. Liu, R. Wang, H. Nie, R.-X. Zhang, J.T. Qiao and N. Danfy (1997) Effects of intrathecal monoamine antagonists on the nociceptive c-Fos expression in a lesioned rat spinal cord. Int. J. of Neurosci., 91:169-180.

H. Wang, R.J. Liu, R.-X. Zhang and J.-T. Qiao (1997) Peripheral NMDA receptors contribute to activation of nociceptors: a c-fos expression study in rats. Neurosci. Lett., 221:101-104.

R.-X. Zhang, R. Wang, J.-Y. Cheng and J.-T. Qiao (1994) Effects of  descending inhibitory systems on the c-fos expression in the rat spinal cord during formalin-induced noxious stimulation. Neuroscience, 58:299-304.

R.-X. Zhang, Z.-P. Mi and J.-T. Qiao (1994) Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin- induced pain. Regulatory Peptides, 51:25-32.

R.-X. Zhang, Z.-P. Mi, Y.-F. Xie and J.-T. Qiao (1993) Morphological evidence for the activation of descending modulatory control by nociceptive afferent pathways: An immunocytochemical study. Brain Res., 603:162-165.

Z.-P. Mi, R.-X. Zhang and J.-T. Qiao (1992) Catecholaminergic projections to the nucleus parafascicularis in the rat brain: a study using Fluoro-gold retrograde tracing combined with catecholamine fluorescence technique. Chin. J. Physiol. Sci., 8:250-256.

R.-X. Zhang, Z.-P. Mi, Y.-F. Xie and J.-T. Qiao (1992) Seretonergic, catecholaminergic and galaninergic projections to the nucleus parafascicularis. NeuroReport, 3:135-138.

R.-X. Zhang, Y.-F. Xie and J.-T. Qiao (1991) Afferent connections of the parafascicular nucleus: a study with retrograde tracing techniques of WGA-HRP and Fluoro-gold in rats. Chin. J. Physiol. Sci., 7:317-325.

R.-X. Zhang, J.-H. Du and Y.-F. Xie (1988) Spinal gray projection to the nucleus parafascicularis and superior colliculus and their interconnection in the rat--retrograde tracing method of HRP. Chin. J. Neuroana., 4:200-206.