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Raymond K. Cross Jr.
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Raymond K. Cross Jr. M.D.

Academic Title: Professor
Primary Appointment: Medicine
Additional Title(s): Director, Inflammatory Bowel Disease Program
Location: UMMC, N3W50
Phone: (410) 706-3387 (office)
Fax: (410) 706-4330

Personal History:

Raymond K. Cross, Jr., M.D.,M.S. is a board certified Gastroenterologist and Associate Professor of Medicine, Division of Gastroenterology and Hepatology, at the University of Maryland School of Medicine in Baltimore, Maryland. He also serves as Director of the Inflammatory Bowel Disease Program at the University of Maryland School of Medicine in Baltimore and is the Chief of the GI section at the Veterans Affairs, Maryland Health Care System Baltimore.

Dr. Cross received his undergraduate degree from Washington and Jefferson College in Washington, Pennsylvania, and his medical degree from the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania. He completed his postgraduate training in Internal Medicine at the University of Maryland and Baltimore VA Medical Centers in Baltimore, Maryland, where he was chosen as Chief Resident. He performed his Gastroenterology fellowship also at the University of Maryland and Baltimore VA Medical Centers in Baltimore. In addition, Dr. Cross has obtained a Master of Science degree in Clinical Research at the University of Maryland School of Medicine, Department of Epidemiology and Preventive Medicine, in Baltimore.

Research Interests:

Dr. Cross has several research interests within the field of inflammatory bowel disease. First, he is testing a home telemanagement system for patients with ulcerative colitis (UC). Telemanagement is a home telemedicine system that assists providers in implementing practice guidelines and in monitoring their patients. Additionally, telemanagement systems assist patients in following action plans and in delivering patients focused education. Dr. Cross has previously tested the system in patients with inflammatory bowel disease, and was able to demonstrate that telemanagement was feasible in this population and that patients accepted the technology. The 12-month study will compare the telemanagement system to best available care in patients with ulcerative colitis. He is planning a separate trial to examine telemanagement in patients with Crohn's disease (CD).

Dr. Cross has evaluated the differences in disparities in outcomes both UC and CD by race at the University of Maryland and VA. He has published his findings in CD in Inflammatory Bowel Diseases, treatment disparities in CD and UC in Inflammatory Bowel Diseases and in Digestive Diseases and Sciences. A follow up study is being conducted to evaluated disparities in disease activity and quality of life in patients with inflammatory bowel disease.

Dr. Cross completed a health survey of physician practicing patterns and knowledge of infliximab side effects among gastroenterologists in Maryland and Washington D.C. The results have been published in Digestive Diseases and Sciences. He has completed a follow up national e-mail survey of American Gastroenterological Association members; the findings have been published in Inflammatory Bowel Diseases.

In addition, Dr. Cross recently completed a study of the impact of medication side effects on the quality of life and disease activity in patients with IBD. To evaluate medication side effects, he used a new questionnaire that had been used in patients with asthma and depression. The findings have been published in the Journal of Clinical Gastroenterology.

Clinical Speciality:

Inflammatory bowel disease (ulcerative colitis, Crohn's disease, microscopic colitis) Infectious colitis Chronic diarrhea Short bowel syndrome


Cross, RK, Longhitano, JP, Rapoport, AP, Cadogan, MA, Brown, LA and Mackowiak, PA. A 78-year-old man with pancytopenia and abnormal lymphocytes. The American Journal of Medical Sciences. 2001;322:151-155.

Cross, RK, Longhitano, JP, Oursler, KA, Saladino, AJ, and Mackowiak, PA. A 75-year-old man with right upper quadrant pain and gallstones. The American Journal of Medical Sciences. 2002;323:146-150.

Cross RK, Jr., Howell C. Two cases of spontaneous epidural abscess in patients with cirrhosis. South Med J. 2003;96:291-293.

Gobert, AP, Cheng, Y., Akhtar, M., Mersey, BD, Blumberg, DR, Cross, RK, Chaturvedi, R., Drachenberg, CB, Boucher, JL, Hacker, A., Casero, RA, Jr., Wilson, KT. Protective role of arginase in a mouse model of colitis. J Immunol. 2004;173:2109-17.

Cross RK, Wilson KT, Binion DG. Polypharmacy and Crohn's disease. Aliment Pharmacol Ther. 2005;21:1211-6

Cross RK, Wilson KT, Binion DG. Narcotic use in patients with Crohn's disease. Am J Gastroenterol 2005;100(10):2225-9.

Cross RK, Binion DG. Narcotic use in patients with Crohn's disease: reply form Drs. Cross and Binion. Am J Gastroenterol 2006;101(6): 1397-8.

Cross RK, Arora M, Finkelstein J. Acceptance of telemanagement is high in patients with inflammatory bowel disease. J Clin Gastroenterol 2006;40(3):200-8.

Cross RK, Jung C, Wasan S, Joshi G, Sawyer R, Roghmann MC. Racial Differences in Disease Phenotypes in Patients With Crohn's Disease. Inflamm Bowel Dis 2006;12(3):192-198.

Castro, HK, Cross, RK, and Finkelstein, J. Using a Home Automated Telemanagement System (HAT): Experiences and Perceptions in Patients with Inflammatory Bowel Disease. AMIA Annu Symp Proc 2006; 872.

Cross, RK, and Finkelstein, J. Feasibility and Acceptance of a Home Telemanagement System in Patients with Inflammatory Bowel Disease: A 6-Month Pilot Study. Dig Dis Sci 2007;52(2):357-364.

Donovan, M, Lunney, K, Carter-Pokras, O, and Cross, RK. Prescribing Patterns and Awareness of Adverse Effects of Infliximab: A Health Survey of Gastroenterologists. Dig Dis Sci. Aug 2007;52(8):1798-1805.

Dunnigan, M, Yfantis, H, Rapoport, AP, Hosseinzadeh, K, Gocke, CD, and Cross, RK. Large cell lymphoma presenting as a flare of colitis in a patient with common variable immune deficiency. Dig Dis Sci. 2007;52(3):830-4.

Cross, RK, Lapshin, O, and Finkelstein, J. Patient Subjective Assessment of Drug Side Effects in Inflammatory Bowel Disease. J Clin Gastroenterol. 2008;42(3):244-51

Flasar MH, Johnson T, Roghmann MC, Cross RK. Disparities in the use of immunomodulators and biologics for the treatment of inflammatory bowel disease: A retrospective cohort study. Inflamm Bowel Dis. 2008;14(1):13-9

Flasar, M, Quezada, S, Bijpuria, P, Wu, Roger, and Cross, RK. Racial Differences in Extent, Severity, and Extraintestinal Manifestations in Patients with Ulcerative Colitis: A Retrospective Cohort Study. Dig Dis Sci. Feb 20 2008.

Greenberg, R, Greenwald, B, Ioffe, O, Roth, S, and Cross, RK. Squamous Dysplasia of the Rectum in a Patient with Ulcerative Colitis Treated with 6-Mercaptopurine. Dig Dis Sci. 2008;53(3):760-4.

Flasar, M, Roghmann, MC, and Cross, RK. Disparities in IBD Care: Time to Correct a Problem: reply from Drs. Flasar, Roghmann, and Cross. Gastroenterology. 2008;134(5):1618-1619.

Warren, JW, Howard, FM, Cross, RK, Good, J, Weissman, M, Wesselmann, U,  Langenberg, P, Greenberg, P, and Clauw, D. Antecedent non-bladder syndromes in a case control study of interstitial cystitis/painful bladder syndrome. Urology. 2009;73(1):52-7.

Quezada, S, Turner, P, Alexiev, B, Daly, B, and Cross, RK. Severe Refractory Orofacial Crohn's Disease: Report of a Case. Dig Dis Sci. 2008.

Cross RK, Cheevers N, Finkelstein J. Home Telemanagement for Patients with Ulcerative Colitis (UC HAT). Dig Dis Sci 2008.

St. Charles, M, Weiss Smith, SR, Beardsley, R, Fedder, DO, Carter-Pokras, O, and Cross, RK. Gastroenterologists Prescribing of Infliximab: A National Survey. Inflamm Bowel Dis. 2009.