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Sylvain  DeLisle

Sylvain DeLisle M.D.C.M.

Academic Title: Associate Professor
Primary Appointment: Medicine
Additional Title(s): Associate Chief of Staff for performance improvement, Baltimore VA Medical Center
Location: Baltimore VA Medical Center, Room 5D-138
Phone: (410) 605-6449
Fax: (410) 605-7914

Personal History:

Dr. DeLisle uses systematic process-of-care analysis and medical informatics to deploy scientific evidence to the point-of-care. He is interested in measuring how informatics tools can improve patient safety and health outcomes. In particular, he leads a team that designs novel software tools that introduce decision support at the time of medication-order entry. Health and economic outcomes of these tools are measured through the development and the query of large clinical, laboratory and administrative databases. Dr. DeLisle is the Principal Investigator of a research program that use those same databases for the purpose of bioterrorism surveillance. Dr. DeLisle is a member of the VA Medical Advisory Panel, a group of 11 physicians that directly help manage the VA National Formulary.


DeLisle S., Bevan D. R., "Impaired neostigmine antagonism of pancuronium during enflurane anesthesia in man" (1982) Br. J. Anaesth. 54: 441-5.

DeLisle S., Lebrun M., Bevan D.R., "Plasma cholinesterase activity and tachyphylaxis during prolonged succinylcholine infusion" (1982) Anesth Analg. 61:941-44

DeLisle S., Krause K-H., Denning, G. and Welsh, M.J., "Effect of inositol trisphosphate and calcium on oscillating elevations of intracellular calcium in Xenopus oocytes" (1990) J. Biol. Chem. 265:11726-11730

DeLisle, S., "The four dimensions calcium signaling in Xenopus oocytes" (1991) Cell Calcium 12:217-227

DeLisle, S., Biggs, D., Wang, A. Martin, J. G., "Effects of prostaglandin E2 on ganglionic transmission in the guinea pig trachea" (1992) Resp. Physiol. 87:131-139

DeLisle, S., Pittet, D., Lew, D.P., Potter, B. S., Welsh, M.J., "InsP3 and Ins(1,3,4,5)P4 act in synergy to stimulate influx of extracellular Ca2+ in Xenopus oocytes" (1992) Am. J. Physiol. 262 (Cell Physiol. 31): C1456-C1463

DeLisle, S. and Welsh, M.J., "Inositol trisphosphate is required for the propagation of Ca2+ waves in Xenopus oocytes" (1992) J. Biol. Chem. 267:7963-7966

Parys, J.B., Sernett, S.W., DeLisle, S., Snyder, P.M., Welsh, M.J., Campbell, K.P., "Isolation, characterization and localization of the inositol 1,4,5-trisphosphate receptor protein in Xenopus laevis oocytes". (1992) J. Biol. Chem. 267:18776-18782

DeLisle, S., Radenberg, T., Wintermantel M.R., Tietz, C., Parys, J.B., Pittet, D.,  Welsh M.J., and Mayr, G.W., "Second messenger specificity of the inositol trisphophate receptor: a reappraisal based on novel inositol phosphates" (1994) Am. J. Physiol. 266 (Cell Physiol. 35): C429-C436

Hennager, D.J., Welsh, M.J. and DeLisle, S., "Changes in either cytosolic or nucleoplasmic inositol 1,4,5-trisphosphate levels can control nuclear Ca2+ concentration". (1995) J. Biol. Chem. 270: 4959-4962

DeLisle, S., Mayr, G., Welsh, M.J., " Inositol phosphate structural requisites for Ca2+ influx". (1995) Am. J. Physiol. (Cell Physiol) 268: C1484-C1491

DeLisle, S., Blondel O., Longo F. J., Schnabel, W. E., Bell, G. I. and Welsh, M. J., "Expression of inositol 1,4,5-trisphosphate receptors changes the Ca2+ signal of Xenopus oocytes" (1996) Am. J. Physiol. (Cell Physiol) 270: C1255-C1261.

DeLisle, S., Marksberry, E.W., Bonnett, C., Jenkins, D.J.,  Potter, B.V.L., Takahashi, M. and Tanzawa, K., "Adenophostin A can Stimulate Ca2+ influx without depleting the inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in the Xenopus oocyte" (1997) J. Biol. Chem. 272: 9956-9961

Xu, W., Longo F.J., Wintermantel M.R., Clark, R.A., DeLisle, S., “Calreticulin modulates capacitative Ca2+ influx by controlling the extent of inositol 1,4,5-trisphophate-induced Ca2+ store depletion” (2000) J. Biol. Chem. 275: 36676-36682