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Christopher Matthews Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Neurology
ccmatthe@umaryland.edu
Location: VAMHCS, 3C-132
Phone: (800) 463-6295, ext 6486
Fax: (410) 605-7906

Personal History:

Education

* B.S., Zoology (University of Calif, Davis)
* Ph.D., Physiology (University of Calif, Davis)
* Fellowship (University of Michigan, Ann Arbor)

Research Interests:

* Motor physiology
* Muscle growth processes
* Neurodegeneration
* Spinal Cord Injury
* ALS


Methodology/Techniques:

* EMG (clinical/animal)
* Transcranial magnetic stimulation
* Small animal surgery
* Immunohistochemistry and electrophoresis
* Laser confocal microscopy and stereology
* Neuronal death assays
* Cell and organotypic slice cultures
* Production and delivery of designer neurotherapeutics
* Animal models of neuromuscular dysfunction


Publications:

Fishman PS, Parks DA, Bowen T, Matthews CC (2009) Localized tetanus in immunized mice. Neurotoxicol. 30:697-701.

Schuh RA, Matthews CC, Fishman PS (2008) Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiates cell death in hippocampal slice cultures. J. Neurosci. Res. 86:3306-3313.

Matthews CC, Zielke HR, Fishman PS, Remington MP, Bowen TG. (2007) Glutamate decarboxylase protects neurons against excitotoxic injury. J. Neurosci Res 85:855-859

Fishman PS, Matthews CC, Parks DA, Box M, Fairweather NF (2006) Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin. J. Neurosci. Res. 83: 1540-1543

Francis JW, Bastia E., Matthews CC, Parks DA, Schwarzschild MA, Brown RH Jr., Fishman PS (2004) Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS. Brain Res. 1011:7-13

C. C. Matthews, H. R. Zielke, D. A. Parks, P. S. Fishman Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slices. Brain Res. 978:59-64 (2003)

Figueiredo, DM, Matthews, CC, Parks, DA, Fairweather, NF, Dougan, G, Wilt, SG, Fishman, PS. Interaction of tetanus toxin derived hybrid proteins with neuronal cells. J. Natural Toxins 4:363-379 (2000)

Christopher C. Matthews, Dayse M. Figueiredo, Jan B. Wollack, Neil F. Fairweather, Gordon Dougan, Robert A. Hallewell, Jean Lud Cadet, and Paul S. Fishman Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation: Requirement for cytosolic distribution. J. Molec. Neurosci. 14:155-166 (2000)

Christopher C. Matthews, H. Ronald Zielke, Jan B. Wollack, and Paul S. Fishman Enzymatic degradation protects neurons from glutamate excitotoxicity. J. Neurochem. 75:1045-1052 (2000)

Paul S. Fishman, Deborah A. Parks, Anil J. Patwardhan and Christopher C. Matthews Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (Hc). Nat. Toxins 7:151-156 (1999)

Matthews CC, Carlsen RC, Gorin F. Nerve activity and trophic factors regulate expression of glycogen phosphorylase in rat skeletal muscle. Cellular Molec. Neurobiol. 18:319-338 (1998)

Matthews CC, Odeh h, Feldman EL. Insulin-like growth factor-1 is an osmoprotectant in human neuroblastoma cells. Neurosci. 79:525-534 (1997)

Matthews CC, Feldman EL. IGF-1 rescues neurons from hyperosmotic induced programmed cell death. J. Cellular Physiol. 166:323-331 (1996) Gandhi D, Matthews CC, Feldman EL. IGF-1 rescues neurons from hyperglycemic, hyperosmotic injury. In: Excerpta medica Int'l Congress Series 1084, Diabetic Neuropathy: New Concepts and Insights, Elsevier Science pp. 183-189 (1995)

Carlsen RC, Klein HW, Matthews CC, Gourley IM. Recovery of free muscle grafts in rat: Improvement is associated with an increase in cyclic adenosine monophosphate concentration or use of the conditioned/test paradigm. Exp. Neurol. 98:616-632 (1987)