Bookmark and Share

Graham W. Aberdeen Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Obstetrics, Gynecology and Reproductive Sciences
gaberdeen@fpi.umaryland.edu
Location: F.C. Bressler Bldg. 11-027
Phone: 410-706-3390
Fax: 410-706-5747
 

Research Interests:

Our research interests involve the central integrative role of estrogen upon a number of physiological processes associated with pregnancy and fetal development. Specifically, the regulation of placental development, maternal adaptations to pregnancy, and fetal organ systems development (i.e. fetal adrenal gland) essential for the establishment and maintenance of pregnancy and maturation of the fetus for extrauterine life at birth. Conceptual advances from our studies have expanded our knowledge of the regulation of fetal-placental development and potentially will lead to new approaches for pregnancy maintenance and fetal-uteroplacental development disorders.


Publications:

Albrecht ED, Aberdeen GW, Pepe GJ. Estrogen elicits cortical zone specific effects on development of the primate fetal adrenal gland. Endocrinology 146: 1737-1744, 2005.

Aberdeen GW, Wiegand SJ, Bonagura TW, Pepe GJ, Albrecht ED. Vascular endothelial growth factor mediates the estrogen-induced breakdown of tight junctions between and increase in proliferation of microvessel endothelial cells in the baboon endometrium. Endocrinology 149:6076-6083, 2008.

Aberdeen GW, Baschat AA, Harman CR, Weiner CP, Langenberg PW, Pepe GJ, Albrecht ED. Uterine and fetal blood flow indices and fetal growth assessed by Doppler ultrasonography after estrogen suppression in the second half of baboon pregnancy. Am J Physiol Heart Circ Physiol. 298(3):H881-889, 2010.

Aberdeen GW, Bonagura TW, Harman CR, Pepe GJ, Albrecht ED. Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: Impact on uterine and fetal blood flow dynamics. Am J Physiol Heart Circ Physiol. 302(10): H1936-1944, 2012.

Bonagura TW, Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED. Prematurely elevating estrogen in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins. Endocrinology 153(6): 2897-2906, 2012.

Pepe GJ. Maniu A, Aberdeen G, Lynch TJ, Albrecht ED. Estrogen regulation of fetal adrenal cortical zone-specific development in the nonhuman primate impacts adrenal production of androgen and cortisol in response to ACTH in adulthood. Endocrinology, 2016.