Dr. Pasetti's research focuses in the evaluation and characterization of vaccine-induced immune responses early in life, particularly the mechanisms by which immune responses are generated in young infants and the pediatric population.
Her group studies different vaccine strategies, antigen delivery systems and immunization schedules in different animal models including neonatal and adult mice and non-human primates. Immunological studies are also conducted in vitro using cells from human newborns obtained from umbilical-cord. Vaccines being tested include attenuated Samonella and Shigella (as live vector vaccines), subunit vaccines, viral vaccines and DNA vaccines. Dr. Pasetti’s group was involved in the development and testing of a new measles DNA vaccine to protect young infants despite the presence of maternal antibodies and the immaturity of their immune system.
Dr. Pasetti’s group is currently working in the development and evaluation of Salmonella-based biodefense vaccines using a heterlogous prime-boost immunization regimen.
Dr. Pasetti also serves as Chief of the Applied Immunology Section at CVD. Her laboratory performs immunological assays (measurement of antibodies, antibody secreting cells, toxin and virus neutralizing antibodies, etc.) for human clinical studies conducted at the CVD and abroad.
Capozzo, V.E., Ramírez, C, Polo, J.M., Ulmer, J., Barry, E.M., Levine, M.M., Pasetti, M.F. Neonatal immunization with a Sindbis-virus DNA measles vaccine induce adult-like neutralizing antibodies and cell-mediated immunity in the presence of maternal antibodies. J Immunol. 2006 1;176(9):5671-81.
Tapia, M., Pasetti, M.F., Cuberos, L., Sow S., Doumbia, M. N., Bagayogo, M., Kotloff, K., Levine, M.M. Measurement of tetanus antitoxin in oral fluid: a tool to conduct serosurveys. Pediatr Infect Dis J. 2006 Sep;25(9):819-25.
Song, M.K., Vindurampulle, C.J., Capozzo, A. V. E., Ulmer, J., Polo, J. M., Pasetti, M. F., Barry, E.M., Levine, M.M. Characterization of Immune responses induced by intramuscular vaccination with DNA vaccines encoding measles virus hemagglutinin and/or fusion proteins. J Virol. 2005 Aug;79(15):9854-61.
Tapia, M., Sow S., Medina S., Lim, Y., Pasetti, M.F., Kotloff, K., Levine, M.M. A serosurvey to identify the window of vulnerability to wild type measles among infants in rural Mali. Am J Trop Med Hyg. 2005 Jul;73(1):26-31.
Simon, J., Pasetti, M.F., Viret, J.F., Munoz, A., Lagos, R., Levine, M.M., Campbell, J.D. A clinical study to assess the safety and immunogenicity of attenuated measles vaccine administered intranasally to healthy adults. Human Vaccines. 2007. In Press
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