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Irina G Luzina
 

Irina G Luzina M.D., Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
iluzina@umaryland.edu
Location: Baltimore VA Medical Center, Room 3C-126
Phone: (410) 706-6474 (office)
Phone: (410) 605-7000 ext 4869 (lab)
Fax: (410) 605-7762

Research Interests:

Dr. Luzina’s research focuses on the role of immune and inflammatory cells – specifically T lymphocytes and macrophages – in autoimmune processes, with an emphasis on lupus and systemic sclerosis. She conducts her studies in animal models of autoimmunity and in patients with autoimmune diseases, as well as in cell culture utilizing modern molecular biology approaches. Dr. Luzina investigates the disturbances in expression of pro-inflammatory and pro-fibrotic cytokines, chemokines and cell surface molecules, as well as changes in the intracellular signaling pathways caused by inflammation and autoimmunity. The ultimate goal of these studies is to identify and characterize potential molecular targets for future anti-inflammatory and anti-fibrotic therapies.

Publications:

Atamas SP, Luzina IG, Handwerger BS, White B. 5'-degenerate 3'-dideoxy-terminated competitors of PCR primers increase specificity of amplification. Biotechniques. 1998 Mar;24(3):445-50.

Luzina IG, Knitzer RH, Atamas SP, Gause WC, Papadimitriou JC, Sztein MB, Storrer CE, Handwerger BS. Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells. Arthritis Rheum. 1999 Mar;42(3):561-8.

Shustov A, Luzina I, Nguyen P, Papadimitriou JC, Handwerger B, Elkon KB, Via CS. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J Clin Invest. 2000 Sep;106(6):R39-47.

Allen EM, Luzina IG, Huang SK. IL-10 kinetics in thyroiditis-prone BB/Wor rats. Autoimmunity. 2000 Dec;32(4):229-40.

Henry PA, Atamas SP, Yurovsky VV, Luzina I, Wigley FM, White B. Diversity and plasticity of the anti-DNA topoisomerase I autoantibody response in scleroderma. Arthritis Rheum. 2000 Dec;43(12):2733-42.

Luzina IG, Handwerger BS. Lessons from animal models of vasculitis. Curr Rheumatol Rep. 2000 Oct;2(5):369-75.

Luzina IG, Atamas SP, Storrer CE, daSilva LC, Kelsoe G, Papadimitriou JC, Handwerger BS. Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol. 2001 Oct;70(4):578-84.

Luzina IG, Atamas SP, Wise R, Wigley FM, Xiao HQ, White B. Gene expression in bronchoalveolar lavage cells from scleroderma patients. Am J Respir Cell Mol Biol. 2002 May;26(5):549-57.

Rus V, Atamas SP, Shustova V, Luzina IG, Selaru F, Magder LS, Via CS. Expression of cytokine- and chemokine-related genes in peripheral blood mononuclear cells from lupus patients by cDNA array. Clin Immunol. 2002 Mar;102(3):283-90.

Atamas SP, Luzina IG, Dai H, Wilt SG, White B. Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling. J Immunol. 2002 Feb 1;168(3):1139-45.

Luzina IG, Atamas SP, Wise R, Wigley FM, Choi J, Xiao HQ, White B. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. Arthritis Rheum. 2003 Aug;48(8):2262-74.

Atamas SP, Luzina IG, Choi J, Tsymbalyuk N, Carbonetti NH, Singh IS, Trojanowska M, Jimenez SA, White B. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol. 2003 Dec;29(6):743-9.

Burns R, Luzina I, Nasir A, Haidaris CG, Barth RK, Gaspari AA. Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens. J Allergy Clin Immunol. 2005 Feb;115(2):383-90.

Fishelevich R, Malanina A, Luzina I, Atamas S, Smyth MJ, Porcelli SA, Gaspari AA. Ceramide-dependent regulation of human epidermal keratinocyte CD1d expression during terminal differentiation. J Immunol. 2006 Feb 15;176(4):2590-9.

Thatcher TH, Luzina I, Fishelevich R, Tomai MA, Miller RL, Gaspari AA. Topical Imiquimod Treatment Prevents UV-Light Induced Loss of Contact Hypersensitivity and Immune Tolerance. J Invest Dermatol. 2006 Apr;126(4):821-31.

Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA. Antenatal Ureaplasma urealyticum respiratory tract infection stimulates pro-inflammatory, pro-fibrotic responses in the preterm baboon lung. Pediatr Res 2006, In Press

Luzina IG, Tsymbalyuk N, Choi J, Hasday JD, Atamas SP. CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity. J Cell Physiol. 2006 Jan;206(1):221-8.

Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas CP. Adenoviral gene transfer of CCLl18 in the lung induces prolonged infiltration of t lymphocytes and transient T lymphocyte-dependent collagen deposition. Arthritis Rheum 2006; In Print

Luzina IG, Highsmith K, Pochetuhin K, Nacu N,  Rao JN, Atamas SP. PKC alpha but not PKC delta or PKC epsilon  mediates CCL 18-stimulated collagen production in pulmonary fibroblast. Am J Respir Cell Mol Biol 2006; In Print