Personal History:Dr. Watson received his medical degree from Washington University in St. Louis, where he stayed to complete a residency in pediatrics (interrupted by a leave to work at a hospital in Haiti). He completed pediatric infectious diseases training at Cleveland Metropolitan General Hospital, doing pararasite molecular biology research at Case Western Reserve University. He then did a research fellowship at the Laboratory of Molecular and Development Immunity at the National Institute of Child Health and Human Development of the NIH, focusing on bacterial vaccine development. He joined the faculty of Johns Hopkins University and then moved to the University of Maryland, where his focus has been on HIV infection in children and pregnant women. He provides clinical care to HIV-exposed infants and HIV-infected infants, children, and adolescents. Research activities include current role as site principle investigator for the International Maternal, Pediatric, and Adolescent AIDS Clinical Trials group. For the past several years he has worked in teaching, advising, and program development for maternal and pediatric HIV care programs in about 10 African and Caribbean countries.
Research Interests:HIV in mothers and children
Clinical Speciality:Pediatric Infectious Diseases
HIV infection in women and children
Constantine, N. T. and D. C. Watson. 2010. Virology and Laboratory Diagnosis of HIV Infection in Infants and Children. In: M.M. Lala and R.H. Merchant (ed), Principles of Perinatal & Pediatric HIV/AIDS. Jaypee Brothers (P) Ltd, India
Darko AD, DC Dim, G Taylor, DC Watson, C-C Sun. Placental Cryptococcus neoformans infection witout neonatal disease: Case report and review of the literature. 2009. Pediatric and Developmental Pathology 12:249-252.
King JR. Acosta EP. Yogev R. Wiznia A. Kraimer J. Graham B. Carey V. Britto P. Jean-Philippe P. Moye J. Watson D. Steady-state pharmacokinetics of lopinavir/ritonavir in combination with efavirenz in human immunodeficiency virus-infected pediatric patients. Pediatric Infectious Disease Journal. 28(2):159-61, 2009.
Persaud D, Ray SC, Kajdas J, Ahonkhai A, Siberry GK, Ferguson K, Ziemniak C, Quinn TC, Casazza JP, Zeichner S, Gange SJ, Watson DC. Slow Human Immunodeficiency Virus Type 1 Evolution in Viral Reservoirs in Infants Treated with Effective Antiretroviral Therapy. AIDS Research & Human Retroviruses. 23:381-90, 2007
Lambert JS, Machado ES, Watson DC, Sill AM, Lim JK, Charurat M, Cunha SM, Afonso AO, Oliviera RH, Tanuri A, DeVico AL. Production of the HIV-suppressive chemokines CCL3/MIP-1alpha and CCL22/MDC is associated with more effective antiretroviral therapy in HIV-infected children. Pediatr Infect Dis J. 2007; 26:935-44.
Machado, E. S., J. S. Lambert, D. C. Watson, A. O. Afonso, S. M. da Cunha, S. A. Nogueira, E. Caride, R. H. Oliveira, A. M. Sill, A. DeVico, and A. Tanuri. 2004. Genotypic resistance and HIV-1 subtype in Brazilian children on dual and triple combination therapy. Journal of Clinical Virology. 30:24 -31.
Persaud, D., G. K. Siberry, A. Ahonkhai, J. Kajdas, D. Monie, N. Hutton, D. C. Watson, T. C. Quinn, S. C. Ray, and R. F. Siliciano. 2004. Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads. Journal of Virology. 78:968-979.
Watson, D. C. and D. R. Counts. 2004. Growth hormone deficiency in HIV-infected children following successful treatment with highly active antiretroviral therapy. Journal of Pediatrics. Journal of Pediatrics. 145:549-51.
Watson, D. C. and J. J. Farley. 1999. Efficacy of and adherence to highly active antiretroviral therapy in children infected with human immunodeficiency virus type 1. Pediatric Infectious Disease Journal 18:682-689.
Watson, D. C., T. L. Collins-Jones, and S. Lovelace. 1999. Antiretroviral therapy of pediatric HIV infection: making hope a reality. AIDS Patient Care and STDs 13:587-599.
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