Research InterestsDescending vasa recta (DVR) are around 15 um diameter arteriolar microvessels through which blood flow reaches the medulla of kidney. And DVR are surrounded by smooth muscle cell-like, pericytes, that impart contractile properties to regulation vasoactivity. My special interesting is the functions and signal transduction pathways of vasoactive in DVR.
Lab Techniques and EquipmentFluorescence measurement, isolate and perfuse vasa-recta in rat, patch-clamp
Pallone TL, Silldorff EP, Zhang Z. Inhibition of calcium signaling in outer medullary descending vasa recta by angiotensin II. Am. J. Physiol. Heart Circ. Physiol. 278: H1248-H1255, 2000.
Zhang Z, Huang JMC, Rhinehart K, Turner MR, Pallone TL. Role of chloride in constriction of descending vasa recta by angiotensin II. Am J Physiol Regul Integr Comp Physiol. 280:R1878-R1886, 2001.
Rhinehart K, Zhang Z, Pallone TL. Ca2+ signaling and membrane potential in descending vasa recta pericytes and endothelia. Am J Physiol Renal Physiol 283: F852-F860, 2002.
Zhang Z, Rhinehart K, Pallone TL. Membrane potential controls calcium entry into descending vasa recta pericytes. Am J Physiol Regul Integr Comp Physiol 283: R949-R957, 2002.
Pallone TL, Zhang Z, Rhinehart K. Physiology of the Renal Medullary Microcirculation. Am J Physiol Renal Physiol 284: F253-F266, 2003.
ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species; Zhong Zhang, Kristie Rhinehart, Whaseon Kwon, Edward Weinman, and Thomas L. Pallone; Am J Physiol Heart Circ Physiol, Aug 2004; 287: H773 - H781;
Response of descending vasa recta to luminal pressure Zhong Zhang and Thomas L. Pallone; Am J Physiol Renal Physiol, Sep 2004; 287: F535 - F542.
Inhibition of K+ conductance in descending vasa recta pericytes by ANG II; Thomas L. Pallone, Chunhua Cao, and Zhong Zhang
Am J Physiol Renal Physiol, Dec 2004; 287: F1213 - F1222.
Chronic ANG II infusion increases NO generation by rat descending vasa recta; Zhong Zhang, Kristie Rhinehart, Glen Solis, Janos Pittner, Whaseon Lee-Kwon, William J. Welch, Christopher S. Wilcox, and Thomas L. Pallone; Am J Physiol Heart Circ Physiol, Jan 2005; 288: H29 - H36.
Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta; Whaseon Lee-Kwon, James B. Wade, Zhong Zhang, Thomas L. Pallone, and Edward J. Weinman; Am J Physiol Cell Physiol, Apr 2005; 288: C942 - C949
Descending vasa recta pericytes express voltage operated Na+ conductance in the rat; Zhong Zhang, Chunhua Cao, Whaseon Lee-Kwon, and Thomas L. Pallone; J. Physiol., Sep 2005; 567: 445 - 457.