Personal HistoryJoseph L. Bryant, DVM, directs the IHV's Animal Model Division and Animal Core Facility. A board certified Laboratory Animal Veterinarian with a background in Comparative Medicine, Dr. Bryant's current research program is an extension of work begun at the National Institutes of Health, where he played a major role in developing a transgenic and gene Knockout Program.
His research team at the IHV has created the first transgenic rats whose DNA has been manipulated to incorporate genes of HIV-1. The rat model opens new areas of human HIV/AIDS study for scientists; its potential is enhanced by similarities in the structure of the rat genome with humans. Ongoing studies include the use of the transgenic rat as a model for HIV/drug abuse, HIV-associated skin diseases and HIV-associated neurological diseases.
Other research efforts focus on the mechanisms of human diseases caused by bacteria and viruses and on details of virus replication to develop better therapies and improved or new diagnostics. The current focus of this work is on the continual development of animal models for AIDS and AIDS-associated malignancies, such as Kaposi's sarcoma and B-cell lymphoma, as well as animal models for breast and prostate cancer. The most recent studies in the division involve the development of animal models of b-cell lymphoma as it relates to infectious causes i.e. mycoplasma fermentans, HIV-1 transgenic mouse model of b-cell lymphoma, and the use of natural plant extracts as anti-cancer agents. Currently, we are also working closely with groups from Jamaica and Nigeria.
Cairo, C., Hebbeler, A. M., Propp, N., Bryant, J. L., Colizzi, V., and Pauza, C. D. (2007). Innate-like gammadelta T cell responses to mycobacterium Bacille Calmette-Guerin using the public Vgamma2 repertoire in Macaca fascicularis. Tuberculosis (Edinb) 87(4), 373-83.
Royal W 3rd, Wang H, Jones O, Tran H, Bryant JL, A vitamin A deficient diet enhances proinflammatory cytokine, Mu opioid receptor, and HIV-1 expression in the HIV-1transgenic rat. J Neuroimmunol. 2007 Apr;185(1-2):29-36
Oladeinde FO, Kinyua AM, Laditan AA, Michelin R, Bryant JL, Denaro F, Makinde JM, Williams AL. Kennedy AP, Bronner Y, Effect of Cnidoscolus acontifolius leaf extract on the blood glucose and insulin levels of inbred type 2 diabetic mice. Cell Mol Biol (Noisy-le-grand) 2007 May 15;53(3):34-41
Igor S. Lukashevich, Ricardo Carrion Jr., Maria S. Salvata, Keith Mansfield, Kathleen Brasky, Juan Zapata, Christiana Cairo, Marco Goicochea, Gia E. Hoosien, Anysha Ticer, Joseph Bryant, Harry Davis, Rasha Hammamieh, Maria Mayda, Marti Jett, Jean Patterson, Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa Fever in small non-human primates, JVAC-D-08-00417R2, 7-21-08
Walter Royal, II and Joseph Bryant, Retinoids and Opiods, American Journal of Infectious Diseases 4 (2): 140-146, 2008
Mahmoud Djavani, Oswald R. Crasta, Yan Zhang, Juan Carlos Zapata, Bruno Sobral, Melissa G. Lechner, Joseph Bryant, Harry Davis, Maria S. Salvato; Gene expression in primate liver during viral hemorrhagic fever; Virology Journal 2209, 6:20
Filiberto Cedano-Laurent, Joseph Bryant, Rita Fishelevich, Odell D. Jones, April Deng, Maria L. Eng, Anthony A Gaspari, J. Roberto Trujillo; Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1; Journal of Dermatological Science 53 (2009) 112-119
Sourcebook of Models for Biomedical Research (2008), Chapter 57 Models in Virology 557-563.
The Way We Will Be 50 Years From Today, (2008), Chapter 42 The View As I Glide By 164-166.
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