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Vladimir V Gerzanich
View Curriculum Vitae 

Vladimir V Gerzanich M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Neurosurgery
Administrative Title: Director Of Pre-Clinical Research
vgerzanich@smail.umaryland.edu
Location: MSTF 618
Phone: (410) 706-1769

Personal History:

Education
M.D., Uzhgorod State University, Uzhgorod, Ukraine 1976-1981
Internship
Intern Pathologist, Department of Pathology, Mukachiv Regional Hospital, Ukraine 1981-1982
Fellowships
Ph.D., Bogomoletz Institute of Physiology, Kiev, Ukraine 1982-1985
Postdoctoral Fellow, Department of Neuroscience, University of Pennsylvania 1992-1998

Research Interests:

Dr. Gerzanich’s areas of interest include ion channels and cerebrovascular pathophysiology of nicotine, cocaine and ischemia.

Publications:

Silinsky, E.M., Gerzanich, V. and Vanner, S.M. (1992) ATP mediates excitatory synaptic transmission in mammalian neurones. Br. J. Pharmacol. 106:762-763.
 
Silinsky, E.M. and Gerzanich, V. (1993) On the excitatory effects of ATP and its role as a neurotransmitter in coeliac neurones of the guinea pig. J. Physiol. (London) 464:197-212.
 
Anand, R., Bason, L., Saedi, M.S., Gerzanich, V., Peng, X., and Lindstrom, J. (1993) Reporter Epitopes: A novel approach to examine transmembrane topology of integral membrane proteins applied to the a1 subunit of the nicotinic acetylcholine receptor. Biochemistry, 32:9975-9984.
 
Peng, X., Katz, M., Gerzanich, V., Anand, R., and Lindstrom, J. (1994) Human _7 acetylcholine receptor: cloning of the _ 7 subunit, pharmacological properties of native receptor and _ 7 homomers expressed in Xenopus oocytes and electrophysiological properties of _ 7 homomers. Mol. Pharmacol.45(3), pp.546-554.
 
Gerzanich, V., Anand, R., and Lindstrom, J. (1994) Homomers of _ 8 subunits of nicotinic receptors functionally expressed in Xenopus oocytes exhibit similar channel but contrasting binding site properties compared to _ 7 homomers. Mol. Pharmacol.. 45:212-220.
 
Barajas-López, C., Espinosa-Luna, R., and Gerzanich, V. (1994) ATP closes a potassium and opens a cationic conductance through different receptors in neurons of guinea pig submucous plexus. JPET.268(3):1396-1402.
 
Peng, X., Gerzanich, V., Anand, R., Whiting, P., Lindstrom, J. (1994) Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol.Pharmacol. 46(3) pp.523-530.
 
Gerzanich, V., Peng, X., Wang, F., Wells, G., Anand, R., Fletcher, S., Lindstrom, J. (1995) Comparative pharmacology of epibatidine - a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 48, 774-782.
 
Barajas-López, C., Huizinga, J., Collins, S., Gerzanich, V., Espinosa-Luna, R., Peres (1996) P2xpurinoreceptors of myenteric neurones from quinea-pig ileum and their unusual pharmacological properties. Br. J. Pharmacol. 119(8):1541-1548
 
Wang, F., Gerzanich, V., Wells, G., Anand, R., Peng, X., Keyser, K., and Lindstrom J. (1996) Assembly of the human neuronal nicotinic receptor _3 subunit with _2, _4, and _5 subunits. J.Biol.Chem. 271:17656-17665.
 
Gerzanich, V., Kuryatov, A., Anand, R., and Lindstrom, J.(1997) “Orphan” _6 nicotinic AChR subunit forms a functional heteromeric receptor. Mol Pharmacol. 51:205-212.
 
Peng, X., Gerzanich, V., Anand, R., Wang, F., and Lindstrom J.(1997) Chronic nicotine treatment upregulates _3 AChRs and _7 AChRs expressed by the human neuroblastoma cell line SH-SY5Y. Mol Pharmacol. 51:776-784.
 
Olale, F., Gerzanich, V., Kuryatov, A., and Lindstrom J.(1997) Chronic nicotine exposure differentially affects the function of human _3, _4, and _7 neuronal nicotinic receptor subtypes. J. Pharmacol. Exp. Ther. 283(2):675-683.
 
Kuryatov, A., Gerzanich, V., Nelson, M., Olale, F., and Lindstrom J. (1997) Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca++ permeability, conductance, and gating of human _4_2 nicotinic acetylcholine receptors. J. Neurosci. 17(23):9035-9047.
 
Gerzanich, V., Wang, F., and Lindstrom J. (1998) _5 subunit alters desensitization, pharmacology, Ca++ modulation, and Ca++ permeability of human neuronal _3 nicotinic receptors. J. Pharmacol. Exp. Ther. 286(1):311-320.
 
Anand, R., Nelson, M., Gerzanich, V., Wells, G., and Lindstrom J. (1998) Determinants of channel gating located in the N-terminal extracellular domain of nicotinic _7 receptor. J. Pharmacol. Exp. Ther. 287(2):469-79.
 
Meyer, E., Kuryatov, A., Gerzanich, V., Lindstrom J., and Papke R.(1998) Analysis of 4OH-GTS-21 selectivity and activity at human and rat _7 nicotinic receptors J. Pharmacol. Exp. Ther. 287(3):918-25.
 
Gerzanich V, Zhang F, West GA, Simard J.M.(2001) Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles. Circ Res. 88(3):359-65.
 
Nelson ME, Wang F, Kuryatov A, Choi CH, Gerzanich V, Lindstrom J. (2001) Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of alpha3beta4 AChRs expressed in permanently transfected HEK cells. J Gen Physiol. 118(5):563-82.
 
Gerzanich V, Ivanova S, Zhou H, Simard JM.(2003) Mislocalization of eNOS and upregulation of cerebral vascular Ca2+ channel activity in angiotensin-hypertension. Hypertension.41(5):1124-30.
 
Dalton S, Gerzanich V, Chen M, Dong Y, Shuba Y, Simard JM. (2003) Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive astrocytes from adult rat brain. Glia.42(4):325-39.
 
Murphy K, Gerzanich V, Zhou H, Ivanova S, Dong Y, Hoffman G, West GA, Winn HR, Simard JM. 2003) Adenosine A2a recptor down-regulates cerebral smooth muscle L-type Ca2+ channel ativity via protein tyrosine phosphatase, not cAMP-dependent protein kinase. Mol Pharmacol. 64(3):640-9.
 
Gerzanich V, Ivanova S, van der Heijden MS, Zhou H, Simard JM (2003) Trans-cellular PCNA gene activation in cerebral vascular smooth muscle by endohthelial oxidative injury in vivo. Arterioscler Thromb Vasc Biol , 23(11):2048-54.
 
Gerzanich V, Ivanov A, Ivanova S, Yang JB, Zhou H, Dong Y, Simard JM.(2003) Alternative splicing of cGKI in angiotensin-hypertension : novel mechanism for nitrate tolerance in vascular smooth muscle. Circ Res, 93(9):805-12
 
Ivanov A, Ivanova S, Melnitchenko L, Gerzanich V, Shuba M, Simard JM. (2003) PCNA upregulation in cerebral vessels with angiotensin II – hypertension: abnormal regulation of Ca2+ channel and nitrate tolerance associated with alternative splicing of cGKI . Neurophysiology, 35(3/4) : 209-14.
 
Gerzanich V, Ivanova S, Simard JM. (2003) Early pathophysiological changes in cerebral vessels predisposing to stroke. Clin Hemorheol Microcirc. 2003;29(3-4):291-4.
 
Ivanov A, Gerzanich V, Ivanova S, Denhaese R, Tsymbalyuk O, Simard JM.(2006) Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. J Physiol. 2006 Jan 1;570(Pt 1):73-84
 
Simard JM, Chen M, Tarasov K, Bhatta S, Ivanova S, Melnichenko L, Tsymbalyuk N, West A, and Gerzanich V. (2006) Newly expressed SUR1-regulated NCa-ATP channel mediates cerebral edema after ischemic stroke. Nature Med. (in press)