Dr Shamsuddin graduated Dhaka Medical College, University of Dhaka in 1972. Following Internship in Massachusetts and Residency training in pathology in Maryland, he was certified by the American Board of Pathology in 1977. In 1980, he received Ph.D. degree from the University of Maryland for his work on colon carcinogenesis. He joined the faculty of the University of Maryland as an Instructor in 1977, and rose through the ranks of Assistant Professor and Associate Professor to become a full Professor in 1988. For his excellence in teaching he received the Best Teacher award from the medical students many times, including the coveted "Golden Apple Award" by the American Medical Students' Association in 1999.
Dr. Shamsuddin has been studying the process of cancer formation and the prevention of cancer since 1975. His research in the steps of colon cancer formation resulted in the development of a very simple and accurate screening test for colon cancer. This rather inexpensive test detects cancers at a very early stage, and even before they have formed; in other words, it can also detect precancerous polyps and other precancerous lesions and conditions. The test has been in use in China since the early 1990's often referred to as "Shams' Test." He further discovered that the colon cancer marker Gal-GalNAc is a common cancer marker expressed through a similar "field-effect" phenomenon; thus forming the basis for a general cancer screening test such as for cancer of the lungs and breast, and possibly prostate and uterine cervix. His book on the subject "Diagnostic Assays for Colon Cancer" by CRC Press (1991) was written for health-care professionals.
In mid 1985, Dr. Shamsuddin started his pioneering experiments on the anti-cancer property of inositol and inositol hexaphosphate (IP-6) - natural constituents of cereals and legumes such as rice, corn, beans etc. For the next two decades, he has reconfirmed and expanded his groundbreaking studies to show the efficacy of IP-6 and inositol against different cancers in various experimental models. Realizing the enormous potential for health benefits of IP-6 and inositol for humans and the general lack of this knowledge, he became most instrumental in organizing the First International Symposium of Disease Prevention by IP-6 and Other Rice Components in Kyoto, Japan (June 8-9, 1998). Dr. Shamsuddin's book on this "IP6: Nature's Revolutionary Cancer Fighter" by Kensington Publishing Corporation, New York, 1998, is written for the general public. Aside from these Dr. Shamsuddin has contributed numerous book-chapters and published over 200 scientific papers.
Anatomic Pathology, Diagnostic Electron Microscopy
Lab Techniques and Equipment:
Chromatography, cell and tissue culture, cancer prevention in vivo, etc.
Shamsuddin, A.K.M., Barrett, L.A., Autrup, H., Harris, C.C., and Trump, B.F.: Long-term organ culture of adult rat colon. Pathology Research and Practice, 163: 362-372, 1978.
Shamsuddin, A.K.M., and Trump, B.F.: Colon epithelium. III. In vitro studies of colon carcinogenesis in Fischer 344 rats. N-methyl-N'-nitro-N-nitrosoguanidine induced changes in colon epithelium in explant culture. Journal of the National Cancer Institute 66: 403-411, 1981.
Shamsuddin, A.K.M., Weiss, L., Phelps, P.C., and Trump, B.F.: Colon epithelium. IV. Human colon carcinogenesis. Changes in human colon mucosa adjacent to and remote from carcinomas of the colon. Journal of the National Cancer Institute 66: 413-419, 1981.
Shamsuddin, A.K.M., Harris, C.C., and Hinzman, M.J.: Localization of aflatoxin B1-nucleic acid adducts in mitochondria and nuclei. Carcinogenesis 8: 109-114, 1987.
Shamsuddin, A.M., and Elsayed, A.M.: A test for detection of colorectal cancer. Human Pathology 19: 7-10, 1988.
Shamsuddin, A.M., Ullah, A., and Chakravarthy, A.K.: Inositol and inositol hexaphosphate suppress cell proliferaÂ¬tion and tumor formation in CD-1 mice. Carcinogenesis 10: 1461-1463, 1989.
Baten, A., Ullah, A., Tomazic, V.J., and Shamsuddin, A.M.: Inositol phosphate induced enhancement of natural killer cell activity correlates with tumor suppression. Carcinogenesis 10: 1595-1598, 1989.
Shamsuddin, A. M., and Yang, G-Y: Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells, Carcinogenesis 16: 1975-1979, 1995.
Yang, G-Y., and Shamsuddin, A. M.: IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: Involvement of intracellular inositol phosphates, Anticancer Research 15: 2479-2488, 1995.
Shamsuddin, A. M.: A simple mucus test for cancer screening. Anticancer Research 16: 2193-2200, 1996.
Shamsuddin, A. M., and Vucenik, I.: IP6 & Inositol in cancer prevention and therapy. Current Cancer Therapy Reviews 1:259-269, 2005.
Vucenik, I., and Shamsuddin, A. M.: Protection against cancer by dietary inositol and IP6. Nutrition & Cancer 55: 109-125, 2006.
Vlaicu, S.I., Tegla, C.A., Cudrici, C.D., Fosbrink, M., Nguyen, V., Azimzadeh, P., Rus, V., Chen, H., Mircea, P.A., Shamsuddin, A., Rus, H.: Epigenetic modifications induced by RGC-32 in colon cancer Experimental and Molecular Pathology. 88:67-76, 2010. Epub 2009 Oct 31.
Matejuk, A., and Shamsuddin, A. M.: IP6 in cancer therapy: Past, present and future. Current Cancer Therapy Reviews 6: 1-12, 2010.
Shamsuddin, A. K., and Bose, S.: IP6 (inositol hexaphosphate) as a signaling molecule, Current Signal Transduction Therapy 7: 291-306, 2012.
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