My research uses a basic understanding of molecular biology to enhance the management of patients with heart disease, and particularly those with cardiomyopathy. As a member of the Cardiomyopathy and Pulmonary Hypertension team, I am actively engaged in both clinical studies as well as basic science investigation in my lab. Bench science efforts have included using cellular and molecular biology techniques to investigate proteins, which intimately influence cardiac muscle function and excitability. Recombinant adenoviral constructs are used to express specific genes in cardiac myocytes which are then studied for changes in contractile properties. Importantly, changes in the presence of these specific proteins occur in the setting of hypertension and may influence cardiac function and progression to heart failure symptoms. My efforts in translational science focuses on the growing importance of subtle variations in the genetic code (single nucleotide polymorphisms, or SNP) having significant influence on susceptibility to disease, disease progression, and response to medical therapy.
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