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Richard  F Mayer
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Richard F Mayer M.D., FAAN, FRSM

Academic Title: Professor Emeritus
Primary Appointment: Neurology
rmayer@som.umaryland.edu
Location: UMMC
Phone: (410) 706-6689 (office)
Phone: (410) 328-6484 (lab)
Fax: (410) 328-5899

Personal History:

EDUCATION
 
  • B.S., St. Bonaventure College, New York, Magna Cum Laude, 1950
  • M.D., University of Buffalo School of Medicine, Alpha Omega Alpha, 1954
 POSTGRADUATE TRAINING
 
  • Medical Internship, Boston City Hospital, Boston, Massachusetts, 1954-1955
  • Fellow in Neurology, Mayo Clinic and Foundation, Rochester, Minnesota, 1955-1956
  • Resident in Neurology, Massachusetts General Hospital, 1956-1957, Boston, Massachusetts
  • Assistant in Research, The National Hospital, Queen Square, 1957-1958, London, England
  • Resident in Neuropathology, Massachusetts General Hospital, 1958-1959, Boston, Massachusetts
  • Research Fellow in Neurology, Harvard Neurological Unit, 1960-1964, Boston City Hospital, Boston, Massachusetts
  • Guest Worker - Laboratory of Neural Control, NINCDS (NIH), 1974-1975, Sabbatical Period

Research Interests:

Clinical experience with neuromuscular diseases, especially myasthenia gravis, polymyositis, peripheral neuropathies – focal and generalized – and motor neuron diseases. Clinical experience with electrodiagnostic techniques used in the diagnosis, treatment and follow-up of patients with neuromuscular diseases. Pathologic evaluation of biopsies of muscle and peripheral nerve using histological and histochemical stains essential in the diagnosis of many diseases of muscle and nerve. Long-term follow-up and management of patients using a variety of treatments such as IVIg, immunosuppressant  meds, pain management for neuropathic pain and cramps. Research over the years has focused on the pathophysiology of neuromuscular disease to improve diagnosis and treatment. My primary activity now is to supervise and teach neuromuscular Fellows and Neurology residents in the EMG/Neuromuscular Clinic and consult on unusual neuromuscular disorders in the Out Patient Clinic.

Publications:

Selected Publications

Sellman MS and Mayer RF:  Weakness and tiredness:  When to suspect myasthenia gravis.  Geriatrics 40:92-112, 1985.

Sellman MS and Mayer RF:  Treatment of myasthenic crisis in late life.  Southern Medical Journal 78:1208-1210, 1985.

Hankins JR, Mayer RF, and Sutterfield JR et al:  Thymectomy for myasthenia gravis:  14-year experience.  Ann. Surg. 201:618-625, 1985.

Bernard PA,  Toyoshima E,  Eccles  CU,  Mayer  RF,  Johnson KP,  and Max SR:  2,4-dichlorophenoxyacetic acid (2,4-D) reduces acetylcholinesterase activity in rat muscle.  Exp. Neurol. 87:544-556, 1985.

Toyoshima E, Mayer RF,  Max SR,  and Eccles C:  2,4-dichlorophenoxyacetic acid  (2,4-D) does not cause polyneuropathy in the rat.  J. Neurol. Sci. 70:225-229, 1985.

Koski CL, Gratz E, Sutherland J, and Mayer RF:  Clinical correlation with anti-peripheral myelin antibodies in Guillain-Barre syndrome.  Ann. Neurol. 19:573-577, 1986.

Toyoshima E, Mayer RF, and Max SR:  The effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on the contractile properties of reinnervated rat skeletal muscle.  Exp. Neurol. 90:601-610, 1985.

Lee RE, Poulos AC, Mayer RF, and Rash JE:  Caveolae preservation in the characterization of human neuromuscular disease.  Muscle and Nerve 9:127-137, 1986.

Toyoshima E, Yeager AM, Brennan S, Santos GW, Moser HW, and Mayer RF:  Nerve conduction studies in the Twitcher mouse (murine globoid cell leukodystrophy).  J. Neurol. Sci. 74:307-318, 1986.

Sellman MS and Mayer RF:  Conduction block in hereditary neuropathy with susceptibility to pressure palsies.  Muscle and Nerve 10:621-625, 1987.

Toyoshima E, Mano Y, Ando K, Ishihara T, Miyazaki S, Yamashita Y, and Mayer RF:  Recording and analysis of gait foot-forces using telemetric force-transducers in patients with Duchenne muscular dystrophy.  Electromyogr. Clin. Neurophysiol. 27:355-361, 1987.

Toyoshima E, Tomi H, Mano Y, Ando K, and Mayer RF:  Kinesiometric analysis of motor dysfunction in patients with subacute myelo-optico neuropathy (SMON).  Electromyogr. Clin. Neurophysiol. 27:361-369, 1987.

Sellman MS and Mayer RF:  Thoraco-abdominal radiculopathy.  South Med. J.  81:199-201, 1988.

Khurana RK, Koski CL, and Mayer RF:  Autonomic dysfunction in Lambert-Eaton myasthenic syndrome.  J. Neurol. Sci. 85:77-86, 1988.

Hsueh I-H, Toyoshima E, and Mayer RF:  The effects of 4-aminopyridine on focal nerve conduction block.  Restorative Neurol. and Neurosci. 1:39-46, 1989.

Rudnicki S, Vriesendorp F, Koski CL, and Mayer RF:  Electrophysiologic studies in the Guillain-Barre syndrome.  Effects of plasma exchange and antibody rebound.  Muscle and Nerve 15:57-62, 1992.

Vriesendorp F, Mayer RF, and Koski CL:  Kinetics of anti-peripheral nerve myelin antibody in plasmapheresed and non-plasmapheresed patients with Guillain-Barre Syndrome.  Arch. Neurol. 48:858-861, 1991.

Mano Y, Nakamuro T, Ikoma K, Takayanagi T, and Mayer RF:  A clinicophysiologic study of central and peripheral motor conduction in hereditary demyelinating motor and sensory neuropathy.  Electromyography and Clinical Neurophysiology, 33:101-107,1993.

Good JL, Khurana RK, Mayer RF, Cintra WM, and Albuquerque EX:  Pathophysiologic studies of neuromuscular function in subacute organophosphate poisoning induced by phosmet.  J. Neurol. Neurosurg. Psychiat. 56:290-294, 1993.

Mano Y, Nakamuro T, Takayanagi T, and Mayer RF:  Ceruletide therapy in action tremor following thalamic hemorrhage.  J. Neurol. 240:144-148, 1993.

Wilensky R, Dwyer B, and Mayer RF:  Relapses in patients with myasthenia gravis treated with azathioprine.  Ann. N.Y. Acad. Sci. 681:591-594, 1993.

Mayer RF:  Myasthenia gravis and diseases of the neuromuscular junction.  Acta Neurol. Sin., 2:9-26, 1993.

Mayer, RF:  Advances in the therapy of neuromuscular disease.  Neurological Therapeutics (Jap) 10:533-543, 1993.

Vriesendorp FJ, Triggs WJ, Mayer RF, and Koski CL:  Electrophysiological studies in Guillain-Barre syndrome; correlation with antibodies to GM1, GD1B, and campylobacter jejuni.  J. Neurol. 242:460-465, 1995.

The Diabetes Control and Complications Trial Research Group:  The effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.  N. Engl. J. Med. 329:977-986, 1993.

Mano Y, Morita Y, Tamura R, Morimoto S, Takayanagi T, and Mayer RF:  The site of action of magnetic stimulation of human motor cortex in a patient with motor neuron disease.  J. Electromyograph. Kinesiol. 3:245-250, 1993.

Mano Y, Nakamuro T, Tamura R, Takayanagi T, Kawanishi K, Tamai S, and Mayer RF:  Central motor reorganization after anastomosis of the musculocutaneous and intercostal nerves following cervical root avulsion.  Ann. Neurol. 38:15-20m 1995.

Weiss MD and Mayer RF:  Temperature-sensitive repetitive discharges in paramyotonia congenita.  Muscle and Nerve 20:195-197, 1997.

Khurana RK and Mayer RF:  Painful trigeminal neuropathy; clinical and pharmacological observations.  Headache 37:522-526, 1997.

Good JL, Chehrenama M, Mayer RF, and Koski CL:  Pulse Cyclophosphamide therapy in chronic inflammatory demyelinating polyneuropathy (CIDP).  Neurology 51:1735-1738, 1998.

Mayer RF:  The motor unit and electromyography.  The Legacy of Derek Denny-Brown.  J. Neurol. Sci. 189:7-11, 2001.

F-FWu, A. Ryan, J. Devaney, M. Warnsteat, Z. Korade-Mirnics, B. Poser, M.J. Escriva, E. Pegoraro, A.S. Yee, K. J. Felice, M.J. Giuliani, R.F. Mayer, T. Mongini, L. Palmucci, M. Marino, R. Riidel, E.P. Hoffman, and C. Fahlke.  Novel CLCN1 Mutations with Unique Clinical and Electrophysiological Consequences.  Brain 125:2392-2407, 2002.


CHAPTERS

Nabseth DC, Mayer RF, and Deterling RA, Jr:  Experimental basis of limb replantation.  In:  Advances in Surgery, Vol 2, C Welch, ed., Year Book Med. Pub. Inc., Chicago, 1966, pp. 35-37.

Mayer RF: The neuromuscular defect in human botulism.  In:  Modern Neurology; Papers in Tribute to Derek Denny Brown.  S Locke, ed., Little, Brown & Co., Boston, pp. 169-186, 1969.

Mayer RF and Garcia-Mullin R:  Peripheral nerve and muscle disorders associated with alcoholism.  In:  The Biology of Alcoholism, Vol. II, B Kissin and H Begleiter, eds., Plenum Publ. Copd., New York, pp. 21-65, 1972.

Mayer RF:  Hereditary neuropathy manifested by recurrent palsies.  In:  Handbook of Clinical Neurology, Vol. 21, Chap. 4, PJ Vinken and GW Bruyn, eds., North-Holland Publ. Co., Amsterdam, pp. 970-1005, 1975.

Mayer RF and Koski CL:  Treatment of acute respiratory muscle failure.  In:  Neurologic Emergencies, M Salcman, ed., Raven Press, 1980.  Chapt. 12, pp 181-206.

Young JL and Mayer RF:  Physiologic Properties and classification of motor units activated by microstimulation in the first dorsal interosseous muscle in man.  In:  Progress in Clinical Neurophysiology, Vol. 9, JE Desmedt, ed., Karger, Basel, 1981, pp 17-25.

Mayer RF and Khurana RK:  Peripheral and autonomic nervous system.  In: Encyclopedic Handbook of Alcoholism, EM Patterson and E Kaufman, eds., Section III, Chapter 13, Gardner Press, New York, 1982, pp 194-203.

Mayer RF and Max SR:  Denervation and reinnervation of skeletal muscle:  Physiological and biochemical aspects.  In:  Myasthenia Gravis, EX Albuquerque and AT Eldefrawi, eds., Chapman and Hall, Ltd., London, 1983, pp 215-246.

Max SR and Mayer RF:  Physiological and biochemical aspects of skeletal muscle denervation and reinnervation.  In:  Peripheral Neuropathy, 2nd Ed, PJ Dyck, PK Thomas, EH Lambert, and R Bunge, eds., Saunders, Philadelphia, 1984, pp 400-409.

Mayer RF, Burke RE, Toop J, Walmsley B, and Hodgson JA:  The effect of spinal cord lesions on motor units in cat medial gastrocnemius muscle.  In:  Recent Achievements in Restorative Neurology, Sir J Eccles and MR Dimitrijevic, eds., S Karger, Basel, 1985, pp 136-149.

Mayer RF:  An outline for the evaluation of neuromuscular disease, Diseases of the neuromuscular junction, Genetic aspects of neuromuscular diseases.  In:  Syllabus, Neuromuscular Diseases, JH Petajan, ed., Veterans Administration, Washington, DC, 1985.

Mayer RF, Koski CL, and Max SR:  Restorative neurology in myasthenia gravis and disorders of peripheral nerve and muscle.  In:  Recent Achievements in Restorative Neurology 2; Progressive Neuromuscular Diseases, M. Dimitrijevic, B Kakulas, and G Vrbova, eds., S Karger, Basel, 1986, pp 184-202.

Koski CL, Khurana R, and Mayer RF:  Guillain-Barre syndrome.  In:  American Family Physician, 34:198-210, 1986.

Mayer RF and Potes E:  Biological toxins.  In:  Current Therapy in Neurologic Diseases, 2nd Ed., RT Johnson, eds., BC Decker, 1987, pp 270-274.

Cherry S and Mayer RF:  Hereditary neuropathy with liability to pressure palsies.  In:  Handbook of Clinical Neurology, Vol. 7, WB Matthews, Ed., Elsevier Science Publishers, Amsterdam, 1987, pp 551-562.

Potes E and Mayer RF:  Treatment of respiratory muscle failure.  In:  Neurologic Emergencies, 2nd Ed., M Salcman, ed., Raven Press, New York City, 1990, pp 218-305.

Mayer RF, Rudnicki S, and Sellman MS:  Muscle contractile properties in dominantly inherited demyelinating polyneuropathy.  In:  Charcot-Marie-Tooth Disorders, RE Lovelace and HK Shapiro, eds., Wiley Liss, New York City, 1990, pp 125-131.