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Christopher  Plowe
 

Christopher Plowe M.D., M.P.H.

Academic Title: Professor
Primary Appointment: Medicine
Secondary Appointments: Epidemiology & Public Health, Microbiology and Immunology
Additional Title(s): Leader, Malaria Group; Associate Director for Research Training, Center for Vaccine Development; Investigator, Howard Hughes Medical Institute
cplowe@medicine.umaryland.edu
Location: HSF1, Room 480
Phone: (410) 706-2491
Phone: (410) 706-3082
Fax: (410) 706-1204
Lab: (410) 706-5932

Personal History:

Christopher Plowe is Professor of Medicine, of Molecular Microbiology and Immunology, and of Epidemiology and Preventive Medicine at the University of Maryland School of Medicine. He is Leader of the Malaria Group and Associate Director for Research Training of the University's Center for Vaccine Development. Dr. Plowe received his B.A. in Philosophy from Cornell University in 1982, an M.D. from Cornell University Medical College in 1986, and an M.P.H. in Tropical Medicine from Columbia University School of Public Health in 1991. He completed an internship and residency in Internal Medicine and was Chief Medical Resident at St. Luke's Hospital of Columbia College of Physicians and Surgeons in New York, New York, and completed fellowships in malaria research at the National Institutes of Health and in Infectious Diseases at Johns Hopkins University School of Medicine in Baltimore, Maryland before joining the faculty of the University of Maryland's Center for Vaccine Development in 1995. He has received a Doris Duke Distinguished Clinical Scientist Award and the Bailey K. Ashford Medal for distinguished work in tropical medicine from the American Society of Tropical Medicine and Hygiene. In 2007 he was selected as a Howard Hughes Medical Institute Investigator in Patient-Oriented Research. Dr. Plowe was elected President of the American Society of Tropical Medicine and Hygiene (ASTMH) for 2015.

Research Interests:

In the Malaria Group we work on malaria drug resistance, genomic and molecular epidemiology, molecular evolution, pathogenesis, HIV-malaria interactions and clinical trials of malaria drugs and vaccines. Plasmodium falciparum malaria resistant to these drugs is widespread in much of South America and Asia, and chloroquine resistance was responsible for large increases in malaria morbidity and mortality in Africa. Resistance to artemisinins, which replaced chloroquine and older drugs, has now emerged in Southeast Asia and threatens to reverse recent reductions in the malaria burden. Our team has developed rapid molecular assays for parasite mutations that cause the parasite to be resistant to specific drugs. These assays are used as public health tools for monitoring resistance in malaria-endemic areas, and we are presently working to develop such markers for artemisinin resistance. In collaboration with colleagues at the University of Mali, we have developed a field research site in the Dogon Country of Mali. This field station is the site of studies of drug resistance, pathogenesis and immunology of severe malaria, and clinical trials of malaria vaccines. In 2011 we published the first report of partial efficacy of a blood-stage malaria vaccine against clinical malaria. In Malawi we work on clinical trials of malaria drugs, molecular epidemiology of drug resistant malaria, malaria in pregnancy and the impact of antimicrobial use on antimalarial drug resistance in persons living with HIV. We reported that chloroquine sensitive malaria had returned to Malawi 12 years after chloroquine was withdrawn. At the Center for Vaccine Development in Baltimore, we study the impact of genetic diversity on malaria drug and vaccine efficacy using high-throughput genotyping, bioinformatics and mathematical modeling. We work with scientists in Africa, Asia and South America to train junior scientists and build research capacity in malaria-endemic countries.

Clinical Speciality:

Tropical Medicine and Travelers' Health


Publications:

  • Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Laurens MB, Pablo J, Jasinskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kouriba B, Rowe JA, Lyke KE, Doumbo OK, Thera MA, Felgner PL, Plowe CV. Seroreactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 Intracellular Domain in Malaria-Exposed Children and Adults. J Infect Dis. 2013 Aug 14;PubMed PMID: 23901079.
  • Mita T, Ohashi J, Venkatesan M, Marma AS, Nakamura M, Plowe CV, Tanabe K. Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. J Infect Dis. 2013 Aug 6;PubMed PMID: 23922363.
  • Wylie BJ, Kalilani-Phiri L, Madanitsa M, Membe G, Nyirenda O, Mawindo P, Kuyenda R, Malenga A, Masonbrink A, Makanani B, Thesing P, Laufer MK. Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi. Malar J. 2013 Jun 4;12:183. PubMed PMID: 23734718; PubMed Central PMCID: PMC3679840.
  • Laurens MB, Billingsley P, Richman A, Eappen AG, Adams M, Li T, Chakravarty S, Gunasekera A, Jacob CG, Sim BK, Edelman R, Plowe CV, Hoffman SL, Lyke KE. Successful Human Infection with P falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection. PLoS One. 2013;8(7):e68969. PubMed PMID: 23874828; PubMed Central PMCID: PMC3712927.
  • Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, Amambua-Ngwa A, Conway DJ, Djimdé AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat Genet. 2013 Apr 28;PubMed PMID: 23624527.
  • Coulibaly D, Rebaudet S, Travassos M, Tolo Y, Laurens M, Kone AK, Traore K, Guindo A, Diarra I, Niangaly A, Daou M, Dembele A, Sissoko M, Kouriba B, Dessay N, Gaudart J, Piarroux R, Thera MA, Plowe CV, Doumbo OK. Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali. Malar J. 2013 Mar 1;12:82. PubMed PMID: 23452561; PubMed Central PMCID: PMC3618208.
  • Ouattara A, Takala-Harrison S, Thera MA, Coulibaly D, Niangaly A, Saye R, Tolo Y, Dutta S, Heppner DG, Soisson L, Diggs CL, Vekemans J, Cohen J, Blackwelder WC, Dube T, Laurens MB, Doumbo OK, Plowe CV. Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications. J Infect Dis. 2013 Feb 1;207(3):511-9. PubMed PMID: 23204168; PubMed Central PMCID: PMC3537449.
  • Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Phyo AP, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC, Silva JC, Ricklefs SM, Porcella SF, Stephens RM, Adams M, Kenefic LJ, Campino S, Auburn S, MacInnis B, Kwiatkowski DP, Su XZ, White NJ, Ringwald P, Plowe CV. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):240-5. PubMed PMID: 23248304; PubMed Central PMCID: PMC3538248.
  • Fairhurst RM, Nayyar GM, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg. 2012 Aug;87(2):231-41. PubMed PMID: 22855752; PubMed Central PMCID: PMC3414557.
  • Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP. Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature. 2012 Jul 19;487(7407):375-9. PubMed PMID: 22722859.
  • Maiga AW, Fofana B, Sagara I, Dembele D, Dara A, Traore OB, Toure S, Sanogo K, Dama S, Sidibe B, Kone A, Thera MA, Plowe CV, Doumbo OK, Djimde AA. No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. Am J Trop Med Hyg. 2012 Jul;87(1):23-8. PubMed PMID: 22764287; PubMed Central PMCID: PMC3391052.
  • Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG, Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malar J. 2012 Jun 18;11:207. PubMed PMID: 22709627; PubMed Central PMCID: PMC3489583.
  • Gandhi K, Thera MA, Coulibaly D, Traoré K, Guindo AB, Doumbo OK, Takala-Harrison S, Plowe CV. Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein. Am J Trop Med Hyg. 2012 May;86(5):775-81. PubMed PMID: 22556073; PubMed Central PMCID: PMC3335679.
  • Venkatesan M, Amaratunga C, Campino S, Auburn S, Koch O, Lim P, Uk S, Socheat D, Kwiatkowski DP, Fairhurst RM, Plowe CV. Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples. Malar J. 2012 Feb 10;11:41. PubMed PMID: 22321373; PubMed Central PMCID: PMC3295709.
  • Laufer MK, Thesing PC, Dzinjalamala FK, Nyirenda OM, Masonga R, Laurens MB, Stokes-Riner A, Taylor TE, Plowe CV. A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. PLoS One. 2012;7(8):e42284. PubMed PMID: 22912697; PubMed Central PMCID: PMC3422316.
  • Lyke KE, Wang A, Dabo A, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. PLoS One. 2012;7(6):e37868. PubMed PMID: 22693628; PubMed Central PMCID: PMC3367916.
  • Lyke KE, Dabo A, Arama C, Daou M, Diarra I, Wang A, Plowe CV, Doumbo OK, Sztein MB. Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium. PLoS One. 2012;7(2):e31647. PubMed PMID: 22348117; PubMed Central PMCID: PMC3279404.
  • Thera MA, Plowe CV. Vaccines for malaria: how close are we?. Annu Rev Med. 2012;63:345-57. PubMed PMID: 22077719; PubMed Central PMCID: PMC3338248.
  • Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara T, Ndounga M, Dysoley L, Endo H, Hombhanje F, Ferreira MU, Plowe CV, Tanabe K. Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations. J Infect Dis. 2011 Dec 15;204(12):1980-8. PubMed PMID: 22021623; PubMed Central PMCID: PMC3209816.
  • Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science. 2011 Oct 28;334(6055):475-80. PubMed PMID: 21903775.
  • Dondorp AM, Fairhurst RM, Slutsker L, Macarthur JR, Breman JG, Guerin PJ, Wellems TE, Ringwald P, Newman RD, Plowe CV. The threat of artemisinin-resistant malaria. N Engl J Med. 2011 Sep 22;365(12):1073-5. PubMed PMID: 21992120.
  • Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S, Lyke KE, Wu Y, Blackwelder WC, Godeaux O, Vekemans J, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, House B, Lanar DE, Dutta S, Heppner DG Jr, Plowe CV. A field trial to assess a blood-stage malaria vaccine. N Engl J Med. 2011 Sep 15;365(11):1004-13. PubMed PMID: 21916638; PubMed Central PMCID: PMC3242358.
  • Lyke KE, Fernández-Viňa MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB. Association of HLA alleles with Plasmodium falciparum severity in Malian children. Tissue Antigens. 2011 Jun;77(6):562-71. PubMed PMID: 21447146; PubMed Central PMCID: PMC3152196.
  • Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, Doumbo OK, Greenwood B, Hall BF, Levine MM, Mendis K, Newman RD, Plowe CV, Rodríguez MH, Sinden R, Slutsker L, Tanner M. A research agenda to underpin malaria eradication. PLoS Med. 2011 Jan 25;8(1):e1000406. PubMed PMID: 21311579; PubMed Central PMCID: PMC3026687.
  • Lyke KE, Laurens M, Adams M, Billingsley PF, Richman A, Loyevsky M, Chakravarty S, Plowe CV, Sim BK, Edelman R, Hoffman SL. Plasmodium falciparum malaria challenge by the bite of aseptic Anopheles stephensi mosquitoes: results of a randomized infectivity trial. PLoS One. 2010 Oct 21;5(10):e13490. PubMed PMID: 21042404; PubMed Central PMCID: PMC2958836. .
  • Laufer MK, Takala-Harrison S, Dzinjalamala FK, Stine OC, Taylor TE, Plowe CV. Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. J Infect Dis. 2010 Sep 1;202(5):801-8. PubMed PMID: 20662717; PubMed Central PMCID: PMC3380613.
  • Beavogui AH, Djimde AA, Gregson A, Toure AM, Dao A, Coulibaly B, Ouologuem D, Fofana B, Sacko A, Tekete M, Kone A, Niare O, Wele M, Plowe CV, Picot S, Doumbo OK. Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali. Int J Parasitol. 2010 Aug 15;40(10):1213-20. PubMed PMID: 20460125; PubMed Central PMCID: PMC3571761.
  • Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su XZ, Plowe CV, Doumbo OK. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine. Malar J. 2010 Jun 21;9:175. PubMed PMID: 20565971; PubMed Central PMCID: PMC2908102.
  • Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, Guindo AB, Traore K, Sissoko M, Diallo DA, Diarra I, Kouriba B, Daou M, Dolo A, Baby M, Sissoko MS, Sagara I, Niangaly A, Traore I, Olotu A, Godeaux O, Leach A, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, Takala SL, Lyke KE, House B, Lanar DE, Dutta S, Heppner DG, Plowe CV. Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial. PLoS One. 2010 Feb 4;5(2):e9041. PubMed PMID: 20140214; PubMed Central PMCID: PMC2816207.
  • Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Chattopadhyay R, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens MB, Plowe CV, Sim BK. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum Vaccin. 2010 Jan;6(1):97-106. PubMed PMID: 19946222.
  • Doumbo OK, Thera MA, Koné AK, Raza A, Tempest LJ, Lyke KE, Plowe CV, Rowe JA. High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children. Am J Trop Med Hyg. 2009 Dec;81(6):987-93. PubMed PMID: 19996426; PubMed Central PMCID: PMC2877664.
  • Plowe CV, Alonso P, Hoffman SL. The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria. J Infect Dis. 2009 Dec 1;200(11):1646-9. PubMed PMID: 19877844.
  • Takala SL, Coulibaly D, Thera MA, Batchelor AH, Cummings MP, Escalante AA, Ouattara A, Traoré K, Niangaly A, Djimdé AA, Doumbo OK, Plowe CV. Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development. Sci Transl Med. 2009 Oct 14;1(2):2ra5. PubMed PMID: 20165550; PubMed Central PMCID: PMC2822345.
  • Takala SL, Plowe CV. Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'. Parasite Immunol. 2009 Sep;31(9):560-73. PubMed PMID: 19691559; PubMed Central PMCID: PMC2730200.
  • Breman JG, Plowe CV. A malaria vaccine for control: more progress. J Infect Dis. 2009 Aug 1;200(3):317-20. PubMed PMID: 19569963.
  • Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP, Wellcome Trust Case Control Consortium, Malaria Genomic Epidemiology Network. Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009 Jun;41(6):657-65. PubMed PMID: 19465909; PubMed Central PMCID: PMC2889040.
  • Plowe CV. The evolution of drug-resistant malaria. Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1:S11-4. PubMed PMID: 19084883; PubMed Central PMCID: PMC2723787.
  • Lyke KE, Daou M, Diarra I, Kone A, Kouriba B, Thera MA, Dutta S, Lanar DE, Heppner DG Jr, Doumbo OK, Plowe CV, Sztein MB. Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial. Vaccine. 2009 Mar 26;27(15):2171-6. PubMed PMID: 19356621; PubMed Central PMCID: PMC2707027.
  • Bell DJ, Nyirongo SK, Mukaka M, Zijlstra EE, Plowe CV, Molyneux ME, Ward SA, Winstanley PA. Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. PLoS One. 2008 Feb 13;3(2):e1578. PubMed PMID: 18270569; PubMed Central PMCID: PMC2229666.
  • Thera MA, Doumbo OK, Coulibaly D, Diallo DA, Kone AK, Guindo AB, Traore K, Dicko A, Sagara I, Sissoko MS, Baby M, Sissoko M, Diarra I, Niangaly A, Dolo A, Daou M, Diawara SI, Heppner DG, Stewart VA, Angov E, Bergmann-Leitner ES, Lanar DE, Dutta S, Soisson L, Diggs CL, Leach A, Owusu A, Dubois MC, Cohen J, Nixon JN, Gregson A, Takala SL, Lyke KE, Plowe CV. Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial. PLoS One. 2008 Jan 23;3(1):e1465. PubMed PMID: 18213374; PubMed Central PMCID: PMC2186380.
  • Sibley CH, Barnes KI, Watkins WM, Plowe CV. A network to monitor antimalarial drug resistance: a plan for moving forward. Trends Parasitol. 2008 Jan;24(1):43-8. PubMed PMID: 18042432.
  • Laufer MK, Djimdé AA, Plowe CV. Monitoring and deterring drug-resistant malaria in the era of combination therapy. Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):160-9. PubMed PMID: 18165489.
  • Arman M, Raza A, Tempest LJ, Lyke KE, Thera MA, Koné A, Plowe CV, Doumbo OK, Rowe JA. Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children. Am J Trop Med Hyg. 2007 Nov;77(5):943-6. PubMed PMID: 17984358; PubMed Central PMCID: PMC2696181.
  • Nyunt MM, Plowe CV. Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance. Clin Pharmacol Ther. 2007 Nov;82(5):601-5. PubMed PMID: 17898709.
  • Rowe JA, Handel IG, Thera MA, Deans AM, Lyke KE, Koné A, Diallo DA, Raza A, Kai O, Marsh K, Plowe CV, Doumbo OK, Moulds JM. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17471-6. PubMed PMID: 17959777; PubMed Central PMCID: PMC2077280.
  • Laufer MK, van Oosterhout JJ, Thesing PC, Dzinjalamala FK, Hsi T, Beraho L, Graham SM, Taylor TE, Plowe CV. Malaria treatment efficacy among people living with HIV: the role of host and parasite factors. Am J Trop Med Hyg. 2007 Oct;77(4):627-32. PubMed PMID: 17978061.
  • Barnes KI, Lindegardh N, Ogundahunsi O, Olliaro P, Plowe CV, Randrianarivelojosia M, Gbotosho GO, Watkins WM, Sibley CH, White NJ. World Antimalarial Resistance Network (WARN) IV: clinical pharmacology. Malar J. 2007 Sep 6;6:122. PubMed PMID: 17822537; PubMed Central PMCID: PMC2014777.
  • Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007 Sep 6;6:121. PubMed PMID: 17822535; PubMed Central PMCID: PMC2008207.
  • Price RN, Dorsey G, Ashley EA, Barnes KI, Baird JK, d'Alessandro U, Guerin PJ, Laufer MK, Naidoo I, Nosten F, Olliaro P, Plowe CV, Ringwald P, Sibley CH, Stepniewska K, White NJ. World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. Malar J. 2007 Sep 6;6:119. PubMed PMID: 17822532; PubMed Central PMCID: PMC2008205.
  • Sibley CH, Barnes KI, Plowe CV. The rationale and plan for creating a World Antimalarial Resistance Network (WARN). Malar J. 2007 Sep 6;6:118. PubMed PMID: 17822531; PubMed Central PMCID: PMC2000470.
  • Méndez F, Herrera S, Murrain B, Gutiérrez A, Moreno LA, Manzano M, Muñoz A, Plowe CV. Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes. Am J Trop Med Hyg. 2007 Sep;77(3):438-43. PubMed PMID: 17827356.
  • Takala SL, Smith DL, Thera MA, Coulibaly D, Doumbo OK, Plowe CV. Short report: rare Plasmodium falciparum merozoite surface protein 1 19-kda (msp-1(19)) haplotypes identified in Mali using high-throughput genotyping methods. Am J Trop Med Hyg. 2007 May;76(5):855-9. PubMed PMID: 17488904; PubMed Central PMCID: PMC2740818.
  • Plowe CV. Combination therapy for malaria: mission accomplished?. Clin Infect Dis. 2007 Apr 15;44(8):1075-7. PubMed PMID: 17366452.
  • Takala SL, Coulibaly D, Thera MA, Dicko A, Smith DL, Guindo AB, Kone AK, Traore K, Ouattara A, Djimde AA, Sehdev PS, Lyke KE, Diallo DA, Doumbo OK, Plowe CV. Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali. PLoS Med. 2007 Mar;4(3):e93. PubMed PMID: 17355170; PubMed Central PMCID: PMC1820605.
  • van Oosterhout JJ, Laufer MK, Perez MA, Graham SM, Chimbiya N, Thesing PC, Alvarez-Martinez MJ, Wilson PE, Chagomerana M, Zijlstra EE, Taylor TE, Plowe CV, Meshnick SR. Pneumocystis pneumonia in HIV-positive adults, Malawi. Emerg Infect Dis. 2007 Feb;13(2):325-8. PubMed PMID: 17479904; PubMed Central PMCID: PMC2725875.
  • Djimde AA, Kirkman L, Kassambara L, Diallo M, Plowe CV, Wellems TE, Doumbo OK. [In vitro cultivation of fields isolates of Plasmodium falciparum in Mali]. Bull Soc Pathol Exot. 2007 Feb;100(1):3-5. PubMed PMID: 17402683.
  • Laufer MK, Plowe CV. The Interaction between HIV and malaria in Africa. Curr Infect Dis Rep. 2007 Jan;9(1):47-54. PubMed PMID: 17254504.
  • Kyriacou HM, Stone GN, Challis RJ, Raza A, Lyke KE, Thera MA, Koné AK, Doumbo OK, Plowe CV, Rowe JA. Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. Mol Biochem Parasitol. 2006 Dec;150(2):211-8. PubMed PMID: 16996149; PubMed Central PMCID: PMC2176080.
  • Thera MA, Doumbo OK, Coulibaly D, Diallo DA, Sagara I, Dicko A, Diemert DJ, Heppner DG Jr, Stewart VA, Angov E, Soisson L, Leach A, Tucker K, Lyke KE, Plowe CV, Mali FMP1 Working Group. Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial. PLoS Clin Trials. 2006 Nov 24;1(7):e34. PubMed PMID: 17124530; PubMed Central PMCID: PMC1851722.
  • Laufer MK, Thesing PC, Eddington ND, Masonga R, Dzinjalamala FK, Takala SL, Taylor TE, Plowe CV. Return of chloroquine antimalarial efficacy in Malawi. N Engl J Med. 2006 Nov 9;355(19):1959-66. PubMed PMID: 17093247.
  • Méndez F, Muñoz A, Plowe CV. Use of area under the curve to characterize transmission potential after antimalarial treatment. Am J Trop Med Hyg. 2006 Oct;75(4):640-4. PubMed PMID: 17038686.
  • Lyke KE, Dabo A, Sangare L, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children. Infect Immun. 2006 Oct;74(10):5718-24. PubMed PMID: 16988248; PubMed Central PMCID: PMC1594876.
  • Laufer MK, Plowe CV. Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions been answered?. Am J Trop Med Hyg. 2006 Sep;75(3):373-4. PubMed PMID: 16968908.
  • Cissoko Y, Daou M, Lyke KE, Dicko A, Diarra I, Kone A, Guindo A, Traore K, Krishnegowda G, Diallo DA, Doumbo OK, Plowe CV, Gowda DC, Sztein MB. Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls. Am J Trop Med Hyg. 2006 Aug;75(2):199-204. PubMed PMID: 16896119; PubMed Central PMCID: PMC2738947.
  • Laufer MK, van Oosterhout JJ, Perez MA, Kanyanganlika J, Taylor TE, Plowe CV, Graham SM. Observational cohort study of HIV-infected African children. Pediatr Infect Dis J. 2006 Jul;25(7):623-7. PubMed PMID: 16804433.
  • Takala SL, Smith DL, Stine OC, Coulibaly D, Thera MA, Doumbo OK, Plowe CV. A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa. Malar J. 2006 Apr 20;5:31. PubMed PMID: 16626494; PubMed Central PMCID: PMC1459863.
  • Deans AM, Lyke KE, Thera MA, Plowe CV, Koné A, Doumbo OK, Kai O, Marsh K, Mackinnon MJ, Raza A, Rowe JA. Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence. Am J Trop Med Hyg. 2006 Apr;74(4):554-63. PubMed PMID: 16606983; PubMed Central PMCID: PMC2738946.
  • Laufer MK, van Oosterhout JJ, Thesing PC, Thumba F, Zijlstra EE, Graham SM, Taylor TE, Plowe CV. Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi. J Infect Dis. 2006 Mar 15;193(6):872-8. PubMed PMID: 16479522.
  • Lyke KE, Dicko A, Dabo A, Sangare L, Kone A, Coulibaly D, Guindo A, Traore K, Daou M, Diarra I, Sztein MB, Plowe CV, Doumbo OK. Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children. Am J Trop Med Hyg. 2005 Dec;73(6):1124-30. PubMed PMID: 16354824; PubMed Central PMCID: PMC2738948.
  • Thera MA, Sehdev PS, Coulibaly D, Traore K, Garba MN, Cissoko Y, Kone A, Guindo A, Dicko A, Beavogui AH, Djimde AA, Lyke KE, Diallo DA, Doumbo OK, Plowe CV. Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease. J Infect Dis. 2005 Nov 15;192(10):1823-9. PubMed PMID: 16235184; PubMed Central PMCID: PMC2740817.
  • Dzinjalamala FK, Macheso A, Kublin JG, Taylor TE, Barnes KI, Molyneux ME, Plowe CV, Smith PJ. Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children. Antimicrob Agents Chemother. 2005 Sep;49(9):3601-6. PubMed PMID: 16127028; PubMed Central PMCID: PMC1195435.
  • Lyke KE, Burges RB, Cissoko Y, Sangare L, Kone A, Dao M, Diarra I, Fernández-Vina MA, Plowe CV, Doumbo OK, Sztein MB. HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls. Infect Immun. 2005 Sep;73(9):5799-808. PubMed PMID: 16113298; PubMed Central PMCID: PMC1231120.
  • van Oosterhout JJ, Laufer MK, Graham SM, Thumba F, Perez MA, Chimbiya N, Wilson L, Chagomerana M, Molyneux ME, Zijlstra EE, Taylor TE, Plowe CV. A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. J Acquir Immune Defic Syndr. 2005 Aug 15;39(5):626-31. PubMed PMID: 16044018.
  • Diallo DA, Doumbo OK, Plowe CV, Wellems TE, Emanuel EJ, Hurst SA. Community permission for medical research in developing countries. Clin Infect Dis. 2005 Jul 15;41(2):255-9. PubMed PMID: 15983925.
  • Heppner DG Jr, Kester KE, Ockenhouse CF, Tornieporth N, Ofori O, Lyon JA, Stewart VA, Dubois P, Lanar DE, Krzych U, Moris P, Angov E, Cummings JF, Leach A, Hall BT, Dutta S, Schwenk R, Hillier C, Barbosa A, Ware LA, Nair L, Darko CA, Withers MR, Ogutu B, Polhemus ME, Fukuda M, Pichyangkul S, Gettyacamin M, Diggs C, Soisson L, Milman J, Dubois MC, Garçon N, Tucker K, Wittes J, Plowe CV, Thera MA, Duombo OK, Pau MG, Goudsmit J, Ballou WR, Cohen J. Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine. 2005 Mar 18;23(17-18):2243-50. PubMed PMID: 15755604.

  • Dzinjalamala FK, Macheso A, Kublin JG, Taylor TE, Barnes KI, Molyneux ME, Plowe CV, Smith PJ. Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. Am J Trop Med Hyg. 2005 Mar;72(3):267-72. PubMed PMID: 15772319.
  • Gregson A, Plowe CV. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev. 2005 Mar;57(1):117-45. PubMed PMID: 15734729.
  • Plowe CV. Antimalarial drug resistance in Africa: strategies for monitoring and deterrence. Curr Top Microbiol Immunol. 2005;295:55-79. PubMed PMID: 16265887.
  • Lyke KE, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe CV, Doumbo OK, Sztein MB. Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun. 2004 Oct;72(10):5630-7. PubMed PMID: 15385460; PubMed Central PMCID: PMC517593.
  • Djimdé AA, Dolo A, Ouattara A, Diakité S, Plowe CV, Doumbo OK. Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones. J Infect Dis. 2004 Aug 15;190(4):853-5. PubMed PMID: 15272415.
  • Lyke KE, Dicko A, Kone A, Coulibaly D, Guindo A, Cissoko Y, Traoré K, Plowe CV, Doumbo OK. Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali. Vaccine. 2004 Aug 13;22(23-24):3169-74. PubMed PMID: 15297070.
  • Laufer MK, Plowe CV. Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies. Drug Resist Updat. 2004 Aug-Oct;7(4-5):279-88. PubMed PMID: 15533765.
  • Diallo DA, Doumbo OK, Dicko A, Guindo A, Coulibaly D, Kayentao K, Djimdé AA, Théra MA, Fairhurst RM, Plowe CV, Wellems TE. A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria. Acta Trop. 2004 May;90(3):295-9. PubMed PMID: 15099817.
  • Cao K, Moormann AM, Lyke KE, Masaberg C, Sumba OP, Doumbo OK, Koech D, Lancaster A, Nelson M, Meyer D, Single R, Hartzman RJ, Plowe CV, Kazura J, Mann DL, Sztein MB, Thomson G, Fernández-Viña MA. Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. Tissue Antigens. 2004 Apr;63(4):293-325. PubMed PMID: 15009803.
  • Plowe CV, Kublin JG, Dzinjalamala FK, Kamwendo DS, Mukadam RA, Chimpeni P, Molyneux ME, Taylor TE. Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study. BMJ. 2004 Mar 6;328(7439):545. PubMed PMID: 14757706; PubMed Central PMCID: PMC381042.
  • Moulds JM, Thomas BJ, Doumbo O, Diallo DA, Lyke KE, Plowe CV, Rowe JA, Birmingham DJ. Identification of the Kna/Knb polymorphism and a method for Knops genotyping. Transfusion. 2004 Feb;44(2):164-9. PubMed PMID: 14962306; PubMed Central PMCID: PMC2877259.
  • Djimdé AA, Doumbo OK, Traore O, Guindo AB, Kayentao K, Diourte Y, Niare-Doumbo S, Coulibaly D, Kone AK, Cissoko Y, Tekete M, Fofana B, Dicko A, Diallo DA, Wellems TE, Kwiatkowski D, Plowe CV. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am J Trop Med Hyg. 2003 Nov;69(5):558-63. PubMed PMID: 14695097.
  • Plowe CV. Monitoring antimalarial drug resistance: making the most of the tools at hand. J Exp Biol. 2003 Nov;206(Pt 21):3745-52. PubMed PMID: 14506209.
  • Lyke KE, Diallo DA, Dicko A, Kone A, Coulibaly D, Guindo A, Cissoko Y, Sangare L, Coulibaly S, Dakouo B, Taylor TE, Doumbo OK, Plowe CV. Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria. Am J Trop Med Hyg. 2003 Sep;69(3):253-9. PubMed PMID: 14628940.
  • Kublin JG, Cortese JF, Njunju EM, Mukadam RA, Wirima JJ, Kazembe PN, Djimdé AA, Kouriba B, Taylor TE, Plowe CV. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis. 2003 Jun 15;187(12):1870-5. PubMed PMID: 12792863.
  • Coulibaly D, Diallo DA, Thera MA, Dicko A, Guindo AB, Koné AK, Cissoko Y, Coulibaly S, Djimdé A, Lyke K, Doumbo OK, Plowe CV. Impact of preseason treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali. Am J Trop Med Hyg. 2002 Dec;67(6):604-10. PubMed PMID: 12518850.
  • Rowe JA, Raza A, Diallo DA, Baby M, Poudiougo B, Coulibaly D, Cockburn IA, Middleton J, Lyke KE, Plowe CV, Doumbo OK, Moulds JM. Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Genes Immun. 2002 Dec;3(8):497-500. PubMed PMID: 12486610.
  • Sulo J, Chimpeni P, Hatcher J, Kublin JG, Plowe CV, Molyneux ME, Marsh K, Taylor TE, Watkins WM, Winstanley PA. Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet. 2002 Oct 12;360(9340):1136-43. PubMed PMID: 12387962.
  • Contreras CE, Cortese JF, Caraballo A, Plowe CV. Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar. Am J Trop Med Hyg. 2002 Oct;67(4):400-5. PubMed PMID: 12452494.
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  • Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?. Trends Parasitol. 2001 Dec;17(12):582-8. PubMed PMID: 11756042.
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  • Djimdé A, Doumbo OK, Steketee RW, Plowe CV. Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria. Lancet. 2001 Sep 15;358(9285):890-1. PubMed PMID: 11567708.
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  • Carlton JM, Fidock DA, Djimdé A, Plowe CV, Wellems TE. Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P falciparum. Curr Opin Microbiol. 2001 Aug;4(4):415-20. PubMed PMID: 11495804.
  • Plowe CV, Doumbo OK, Djimde A, Kayentao K, Diourte Y, Doumbo SN, Coulibaly D, Thera M, Wellems TE, Diallo DA. Chloroquine treatment of uncomplicated Plasmodium falciparum malaria in Mali: parasitologic resistance versus therapeutic efficacy. Am J Trop Med Hyg. 2001 May-Jun;64(5-6):242-6. PubMed PMID: 11463110.
  • Salcedo E, Cortese JF, Plowe CV, Sims PF, Hyde JE. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Mol Biochem Parasitol. 2001 Feb;112(2):239-52. PubMed PMID: 11223131.
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  • Agarwal A, Guindo A, Cissoko Y, Taylor JG, Coulibaly D, Koné A, Kayentao K, Djimde A, Plowe CV, Doumbo O, Wellems TE, Diallo D. Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. Blood. 2000 Oct 1;96(7):2358-63. PubMed PMID: 11001883.
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  • Cortese JF, Plowe CV. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol. 1998 Aug 1;94(2):205-14. PubMed PMID: 9747971.
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  • Perry RT, Plowe CV, Koumaré B, Bougoudogo F, Kotloff KL, Losonsky GA, Wasserman SS, Levine MM. A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali. Bull World Health Organ. 1998;76(1):63-71. PubMed PMID: 9615498; PubMed Central PMCID: PMC2305629.
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